Opiod Induced Constipation Drugs Market Size, Market Share, Application Analysis, Regional Outlook, Growth Trends, Key Players, Competitive Strategies and Forecasts, 2020 to 2028

Key Market Insights:

The global opioid induced constipation drugs market is rising at a significant pace, projected to rise at a CAGR of 4.7% during the estimated period from 2020 to 2028, starting from US$ 2,656.4 Mn in 2019.

The mechanism of action of opioid analgesics through binding to the mu, delta, and kappa receptors present in the brain by crossing the blood-brain barrier and giving the desired analgesic effect to treat non-cancer pain. In addition, the opioids bind to the mu receptors present in the gastrointestinal tract, which result in a contraction of the smooth muscles and alter the peristaltic movement causing constipation. Usually, the patients opt for over the counter osmotic laxatives and stimulant cathartics, which have been beneficial in providing relief from constipation in patients taking opioid analgesics for 3-4 weeks. In patients seeking palliative care, doctors prescribe mu-receptor antagonists and prostaglandin derivatives to cure opioid induced constipation.

In the present scenario, prescribed drugs are dominating the market on account of an increasing number of patients showing resistance to over-the-counter laxatives and cathartics. Moreover, opioid analgesics binds to the mu receptors of the gastrointestinal tract causing severe contraction of smooth muscles, altering the peristaltic activity of the gut motility, thus leading to chronic constipation. Physicians usually prescribe branded drugs such as methylnaltrexone bromide and naloxegol (mu-receptor antagonists) and prostaglandin derivatives such as lubiprostone to gain immediate relief from constipation by increasing fluid retention and stool softening. Over the counter (OTC) osmotic laxatives and stimulant cathartics are the drugs of the first choice by the patients to treat constipation. OTC products have shown good results in patients taking opioid analgesics for less than 4 weeks.

In addition, lockdown restrictions and the need to maintain social distancing due to the ongoing COVID-19 pandemic have resulted in more number of people staying at home. Hence, a sedentary lifestyle has resulted in the development of opioid induced constipation. In addition, irrational intake of OTC drugs and lack of physical activity will further aggravate the occurrence of opioid induced constipation in the elderly population

Regional Analysis:

North America currently leads the opioid induced constipation drugs market due to the increasing number of patients suffering from non-cancer pain and rising public health awareness resulting in early diagnosis and treatment for osteoarthritis and rheumatoid arthritis. The European opioid induced constipation drugs market is driven by an increasing number of patients seeking palliative care in rehabilitation centers and the rising geriatric population suffering from non-cancer pain. The Asia Pacific is set to register significant growth in opioids induced constipation drugs market on account of the huge population base suffering from chronic diseases such as rheumatoid arthritis and fibromyalgia associated with strenuous working conditions. Rising use of opioids due to easy availability and poor regulation drives the Asia Pacific opioids induced constipation drugs market.

This report is a comprehensive research study of the global opioid induced constipation drugs market that elaborates the major trends in the market based on quantitative and qualitative research. This report provides a detailed description of the global opioid induced constipation drugs market segmenting market by drug types and geography. This report aids the market stakeholders to make improved decisions and strategies in the opioid induced constipation drugs market.

Based on the drug types, the global opioid induced constipation drugs market is segmented as follows:

• Methylnaltrexone Bromide
• Lubiprostone
• Naloxegol
• Naldemedine
• Docusate Sodium
• Others

Based on the prescription types, the global opioid induced constipation drugs market is segmented as follows:

• Prescribed
• Over the Counter

Based on geographical demarcation, the global opioid induced constipation drugs market is studied by segmenting the market into major economic regions as follows:

• North America
• United States
• Canada
• Europe
• Germany
• United Kingdom
• Rest of Europe
• Asia Pacific (APAC)
• Japan
• China
• Rest of APAC
• Latin America
• Brazil
• Mexico
• Rest of Latin America
• Middle East and Africa (MEA)
• Gulf Cooperation Council (GCC)
• Rest of Middle East & Africa

List of Companies Covered:

• AstraZeneca, Plc.
• Cubist Pharmaceuticals
• Daiichi Sankyo Co., Ltd.
• Ironwood Pharmaceuticals, Inc.
• Pfizer, Inc.
• Progenics Pharmaceuticals, Inc.
• Salix Pharmaceuticals Ltd.
• Shionogo & Co., Ltd.
• Sucampo Pharmaceuticals, Inc.
• Synergy Pharmaceuticals, Inc.

Historical & Forecast Period:

This study report represents analysis for each segment from 2018 to 2028 considering 2019 to be the base year. Compounded Annual Growth Rate (CAGR) for each of the respective segments estimated for the forecast period from 2020 to 2028.

The current report also comprehends qualitative and qualitative market valuation factors such as key market drivers, market trends, restraints, and opportunities that give a better market understanding of the overall opioid induced constipation drugs market. Additionally, the global report also comprises a graphical representation of the competitive landscape based on their market initiatives and strategies, product portfolio, and business strengths.

Key questions answered in this report:

• What are the current market trends and dynamics in the opioid induced constipation drugs market and valuable opportunities for emerging players?
• Which segment accounts for the fastest CAGR during the forecast period?
• What are the drivers of the opioid induced constipation drugs market?
• Notable developments going on in the opioid induced constipation drugs market.
• What is the market trend and dynamics in emerging markets such as Asia Pacific, Latin America, and Middle East & Africa?
• A comparative scenario for all the segments for years 2019 (actual) and 2028 (forecast)

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