The bone grafts and substitutes market size valued for $2,586.30 million in 2021 and is estimated to reach $4,005.26 million by 2031, exhibiting a CAGR of 4.5% from 2022 to 2031.
Bone grafts and substitutes refers to materials and techniques used to replace or regenerate missing or damaged bone tissue. They are typically used when the body's natural healing process is insufficient to repair the damaged bone. These treatments are commonly used in orthopedic and dental surgeries to repair bone fractures, reconstruct bone defects, or enhance bone growth.
The major factors driving the growth of bone grafts and substitutes market include increase in incidence of musculoskeletal disorders, technological advancements for development of advanced bone grafts, and rise in number of sport injuries. There is an increase in the prevalence of musculoskeletal disorders such as osteoarthritis, osteoporosis, and other bone-related conditions, which is driving the demand for bone grafts and substitutes. Bone grafts and substitutes are often used to restore bone mass and promote healing as these conditions can cause bone loss. In addition, there is an increase in the number of surgical procedures performed each year and many of these procedures require the use of bone grafts and substitutes. For instance, spinal fusion surgery which often involves the use of bone grafts or substitutes, is one of the fastest-growing surgical procedures in the U.S. Thus, increase in number of these surgeries results in demand of bone grafts and substitutes and also propels the market expansion.
In addition, advances in technology have led to the development of new bone grafts and substitutes that offer improved biocompatibility, better healing properties and reduced risk of infection or rejection. These advancements are driving the demand for newer, and advanced products. Further, rise in the number of new product launches by key players of the market is anticipated to drive the growth of bone grafts and substitutes market. For instance, in February 2022, Orthofix Medical Inc., launched Opus BA, a synthetic bioactive bone graft solution for cervical and lumbar spine fusion procedures. Thus, rise in new product launches by key players further drives the growth of the bone grafts and substitutes market.
Furthermore, rise in adoption of strategies by key players of the market cater the demand for bone grafts and substitutes is expected to drive the growth of the market. For instance, in January 2023, Zimmer Biomet Holdings, Inc. acquired Embody, Inc., a privately-held medical device company focused on soft tissue healing. The acquisition includes Embody’s complete portfolio of collagen-based bio integrative solutions to support healing in the most challenging orthopedic soft tissue injuries. Thus, rise in adoption of such strategies is anticipated to drive the growth of the market.
However, strict regulatory pathways for approval are the factors that restrain the growth of the market. In addition, absence of favorable reimbursement policies in some countries is expected to hinder the growth of the market. Furthermore, rise in demand for advanced bone grafts, increase in awareness about available bone grafts & substitutes and rise in investments for orthopedics offer lucrative opportunities for the key players of the bone grafts and substitutes market.
The bone grafts and substitutes market is segmented into type, application, end user and region. On the basis of type, the market is categorized into allografts, bone grafts substitute and cell-based matrices. On the basis of application, the market is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. On the basis of end user, the market is classified into hospitals, specialty clinics and others. Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).
Major key players that operate in the global bone grafts and substitutes market are Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences and Orthofix Holdings, Inc.
Bone grafts and substitutes refers to materials and techniques used to replace or regenerate missing or damaged bone tissue. They are typically used when the body's natural healing process is insufficient to repair the damaged bone. These treatments are commonly used in orthopedic and dental surgeries to repair bone fractures, reconstruct bone defects, or enhance bone growth.
The major factors driving the growth of bone grafts and substitutes market include increase in incidence of musculoskeletal disorders, technological advancements for development of advanced bone grafts, and rise in number of sport injuries. There is an increase in the prevalence of musculoskeletal disorders such as osteoarthritis, osteoporosis, and other bone-related conditions, which is driving the demand for bone grafts and substitutes. Bone grafts and substitutes are often used to restore bone mass and promote healing as these conditions can cause bone loss. In addition, there is an increase in the number of surgical procedures performed each year and many of these procedures require the use of bone grafts and substitutes. For instance, spinal fusion surgery which often involves the use of bone grafts or substitutes, is one of the fastest-growing surgical procedures in the U.S. Thus, increase in number of these surgeries results in demand of bone grafts and substitutes and also propels the market expansion.
In addition, advances in technology have led to the development of new bone grafts and substitutes that offer improved biocompatibility, better healing properties and reduced risk of infection or rejection. These advancements are driving the demand for newer, and advanced products. Further, rise in the number of new product launches by key players of the market is anticipated to drive the growth of bone grafts and substitutes market. For instance, in February 2022, Orthofix Medical Inc., launched Opus BA, a synthetic bioactive bone graft solution for cervical and lumbar spine fusion procedures. Thus, rise in new product launches by key players further drives the growth of the bone grafts and substitutes market.
Furthermore, rise in adoption of strategies by key players of the market cater the demand for bone grafts and substitutes is expected to drive the growth of the market. For instance, in January 2023, Zimmer Biomet Holdings, Inc. acquired Embody, Inc., a privately-held medical device company focused on soft tissue healing. The acquisition includes Embody’s complete portfolio of collagen-based bio integrative solutions to support healing in the most challenging orthopedic soft tissue injuries. Thus, rise in adoption of such strategies is anticipated to drive the growth of the market.
However, strict regulatory pathways for approval are the factors that restrain the growth of the market. In addition, absence of favorable reimbursement policies in some countries is expected to hinder the growth of the market. Furthermore, rise in demand for advanced bone grafts, increase in awareness about available bone grafts & substitutes and rise in investments for orthopedics offer lucrative opportunities for the key players of the bone grafts and substitutes market.
The bone grafts and substitutes market is segmented into type, application, end user and region. On the basis of type, the market is categorized into allografts, bone grafts substitute and cell-based matrices. On the basis of application, the market is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. On the basis of end user, the market is classified into hospitals, specialty clinics and others. Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).
Major key players that operate in the global bone grafts and substitutes market are Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences and Orthofix Holdings, Inc.
Key Benefits For Stakeholders
- This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the bone grafts and substitutes market analysis from 2021 to 2031 to identify the prevailing bone grafts and substitutes market opportunities.
- The market research is offered along with information related to key drivers, restraints, and opportunities.
- Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders make profit-oriented business decisions and strengthen their supplier-buyer network.
- In-depth analysis of the bone grafts and substitutes market segmentation assists to determine the prevailing market opportunities.
- Major countries in each region are mapped according to their revenue contribution to the global market.
- Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
- The report includes the analysis of the regional as well as global bone grafts and substitutes market trends, key players, market segments, application areas, and market growth strategies.
Key Market Segments
By Type
- Allografts
- Type
- Machined allografts
- Demineralized bone matrix
- Bone grafts substitutes
- Type
- Bone morphogenic proteins (BMP)
- Synthetic bone grafts
- Cell based matrices
By Application
- Spinal fusion
- Trauma
- Joint reconstruction
- Dental bone grafting
- Craniomaxillofacial
By End user
- Hospitals
- Specialty clinics
- Others
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- UK
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- Japan
- China
- India
- Australia
- South Korea
- Rest of Asia-Pacific
- LAMEA
- Brazil
- Saudi Arabia
- South Africa
- Rest of LAMEA
Key Market Players
- Arthrex, Inc.
- Johnson & Johnson
- Medtronic plc
- Stryker Corporation
- Baxter International Inc.
- Xtant Medical Holdings, Inc.
- Integra LifeSciences
- NuVasive, Inc.
- Zimmer Biomet Holdings, Inc.
- Orthofix Holdings, Inc.
Table of Contents
CHAPTER 1: INTRODUCTION
CHAPTER 2: EXECUTIVE SUMMARY
CHAPTER 3: MARKET OVERVIEW
CHAPTER 4: BONE GRAFTS AND SUBSTITUTES MARKET, BY TYPE
CHAPTER 5: BONE GRAFTS AND SUBSTITUTES MARKET, BY APPLICATION
CHAPTER 6: BONE GRAFTS AND SUBSTITUTES MARKET, BY END USER
CHAPTER 7: BONE GRAFTS AND SUBSTITUTES MARKET, BY REGION
CHAPTER 8: COMPETITIVE LANDSCAPE
CHAPTER 9: COMPANY PROFILES
List of Tables
List of Figures
Executive Summary
According to the report titled, “Bone Grafts and Substitutes Market," the bone grafts and substitutes market was at $2,586.30 million in 2021, and is projected to reach $4,005.26 million by 2031, registering a CAGR of 4.5% from 2022 to 2031.Bone grafts and substitutes are medical materials or products used to replace or augment missing or damaged bone tissue in the body. They are used in various surgical procedures to promote bone healing and regeneration, such as spinal fusion, joint reconstruction, and bone fracture repair.
Key factors driving the growth of the bone grafts and substitutes market are rise in prevalence of bone and joint disorders, rise in number of surgeries and presence of major key players offering bone grafts. For instance, according to report of Australian Orthopedic Association National Joint Replacement Registry 2022, 10.9% rise in joint replacement surgeries as compared to 2019. Thus, rise in number of surgeries is expected to fuel the growth of market. Further, rise in prevalence of musculoskeletal disorders is a major factor expected to drive the growth of the market. For instance, according to an article published in Taylor & Francis 2021, in Germany, around 64-92% of dentists reported musculoskeletal disorders. Thus, rise in musculoskeletal disorders in dentists is expected to drive the growth of the market.
Further, geriatric population is prone to many orthopedic disorders such as arthritis, back pain, and neck pain, which results in demand for bone grafts and substitutes. Thus, rise in geriatric population is expected to contribute to the growth of the bone grafts and substitutes market. For instance, data by the World Health Organization (WHO) 2021 stated that 1.4 billion of the world’s population is aged 60 years and over and is expected to double by 2050. In addition, a rise in the number of hip and knee fractures across the globe results in demand for bone grafts substitutes and thus, contributes to the market expansion.
Moreover, rising number of fractures in many countries drives the demand of bone grafts and substitutes. In Brazil, rise in prevalence of hip fractures in the elderly population due to osteoporosis is a major factor driving the growth of the market. For instance, according to an article by Archives of Osteoporosis 2022, number of hip fractures in Brazil is expected to double by 2040, reaching almost 200,000 fractures per year. Thus, rise in number of hip fractures leads to demand for bone grafts and is anticipated to drive the growth of the market.
Further, rise in adoption of strategies such as contract, partnership and strategic alliance by key players of market is expected to propel the market expansion. For instance, in July 2021, Integra LifeSciences Holding Corporation, a leading global medical technology company, announced contract with Vizient, Inc. for manufacturing of SurgiMend Collagen Matrix for soft tissue. Thus, rise in such adoption of such strategies drive the market growth.
The market also offers growth opportunities to the key players in the market. Many developing regions such India and Brazil offer lucrative opportunities to key players of bone grafts and substitutes market owing to high population base, increase in demand of advanced bone graft substitutes and increase in healthcare spending. In addition, government initiatives regarding orthopedic disorders and surgeries in various countries and medical tourism fuels the growth of market.
The bone grafts and substitutes market is segmented into type, application, end user and region. On the basis of type, the market is categorized into allografts, bone grafts substitute and cell-based matrices. On the basis of application, the market is divided into spinal fusion, trauma, craniomaxillofacial surgery, joint reconstruction and dental bone grafting. On the basis of end user, the market is classified into hospitals, specialty clinics and others. Region wise, the market is analyzed across North America (the U.S., Canada, and Mexico), Europe (Germany, France, the UK, Italy, Spain, and rest of Europe), Asia-Pacific (Japan, China, Australia, India, South Korea, and rest of Asia-Pacific), and LAMEA (Brazil, South Africa, Saudi Arabia, and rest of LAMEA).
The key players profiled in the study include Arthrex, Inc., Johnson & Johnson, Medtronic plc, NuVasive, Inc., Stryker Corporation, Zimmer Biomet Holdings, Inc., Baxter International Inc., Xtant Medical Holdings, Inc., Integra LifeSciences and Orthofix Holdings, Inc. The players in the market have been actively engaged in the adoption various strategies such as acquisition, product launch, product approval, partnership, strategic alliance and contract to remain competitive and gain advantage over the competitors in the market.
Key Market Insights
- On the basis of type, the bone graft substitutes segment was highest contributor to the market in 2021.
- On the basis of application, the spinal fusion segment dominated the market in terms of revenue in 2021. However, the joint reconstruction segment is anticipated to grow at the highest CAGR during the forecast period.
- On the basis of end user, the hospitals segment dominated the market in terms of revenue in 2021.
- Region wise, North America generated the largest revenue in 2021. However, Asia-Pacific is anticipated to grow at the highest CAGR during the forecast period.
Companies Mentioned
- Arthrex, Inc.
- Johnson & Johnson
- Medtronic plc
- Stryker Corporation
- Baxter International Inc.
- Xtant Medical Holdings, Inc.
- Integra LifeSciences
- NuVasive, Inc.
- Zimmer Biomet Holdings, Inc.
- Orthofix Holdings, Inc.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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