+353-1-416-8900REST OF WORLD
+44-20-3973-8888REST OF WORLD
1-917-300-0470EAST COAST U.S
1-800-526-8630U.S. (TOLL FREE)

Bone Grafts and Substitutes Market Size, Share & Trends Analysis Report By Material Type; By Application Type; By Region - Segment Forecast, 2021 - 2028

  • PDF Icon

    Report

  • 120 Pages
  • June 2021
  • Region: Global
  • Polaris Market Research
  • ID: 5397043
The global bone grafts and substitutes market size is expected to reach USD 5.26 billion by 2028 according to this new study. The report “Bone Grafts and Substitutes Market Size, Share & Trends Analysis Report, By Material Type (Natural, Synthetic); By Application Type (Spinal Fusion, Craniomaxillofacial, Long Bone); By Region, Segment Forecasts, 2021-2028” gives a detailed insight into current market dynamics and provides analysis on future industry growth.



For decades, bone grafts have been utilized in regenerate the bone, restore the structure and relieve pain. Autographs were traditionally utilized for bone grafting, using the bone of patience itself as a graft. Added to this, autologous bone grafts have been regarded as bone transplant gold standard. However, the use of autologous bone grafts in both tissue harvesting and transplant locations includes the danger of transferring infection during surgical procedures. This can lead to delayed healing of wound and extended stays in hospital. In order to overcome the drawbacks associated with autologous grafts, allografts were introduced in the market.

Increasing instances of orthopedic surgery and musculoskeletal illnesses (MSD) requiring the use of bone grafts and replacements will drive market growth. Approximately 3 million musculoskeletal interventions operate annually in the United States, for instance, according to the American Academy of Orthopedic Surgeons. Moreover, bone grafts are also reported to be used worldwide in approximately 2.2 million orthopedic procedures. Increasing use of bone grafts combined with growing instances of illnesses requiring the use of these products will therefore increase the development of the market for bone grafts and replacements. Allografts have both osteo-inductive and osteo-conductive characteristics and therefore serve as autograph replacements. During the forecast period, ready availability of allografts in different shapes and sizes that can be processed in different forms like chips and others as required is likely to increase the allografts segment of the bone grafts and replacements market.

Bone grafts and substitutes have been used to treat flaws considerably. Osteogenesis, osteoinduction, osteoconduction, and structural support are the basic characteristics of bone graft. The fast advances seen in technology and product innovations fuel the development of the worldwide industry for bone grafts and replacements. In addition, the growing amount of musculoskeletal circumstances such as osteoarthritis, rheumatoid arthritis, and psoriatic arthritis is another key factor likely to further boost the worldwide bone grafts and replacements market over the timeframe forecast.

Increasing the amount of bone grafting processes, growing aging population with demand for high-quality musculoskeletal function in ancient age, and increasing penetration of specialty orthopedic clinics and health insurance are the main drivers of industry growth. The danger and complications of bone grafting processes and elevated bone graft therapy costs, however, restrict industry growth. Growing consumer awareness of appearance, increasing preference for natural / organic goods, increasing disposable income in emerging economies, the accessibility of technologically sophisticated are driving this industry’s development. On the other side, it is probable that deceptive marketing methods will restrict market growth. It is anticipated that the increasing number of middle-aged people, a fast-paced life and a burgeoning urban population will further drive demand.

In the years ahead, North America is expected to lead the worldwide bone grafts industry. North America retained approximately 38 percent of worldwide bone grafts and replacement market share in 2020. In specific, the US is leading the worldwide industry by generating enormous demand for products due to a large incidence of trauma-related accidents and orthopedic illnesses. Rising osteoarthritis events have resulted to increased demand for bone grafts and replacements used for therapy and transplantation. This also drives the North American bone grafts & substitutes market. In the years ahead, Europe is expected to demonstrate fast development in bone grafts and replace the globally. Due to the increasing demand for innovative and technologically advanced therapies for chronic disease therapy and the existence of major players, Europe was the world’s second major industry in 2020. Some of the main players on the industry are Orthofix Holdings, Inc.; DePuy Synthes; Medtronic PLC; Stryker Corp, Nuvasive, Inc.; and AlloSource, Inc. among other players.

The publisher has segmented the bone grafts and substitutes industry report on the basis of material, application type, and region:

Bone Grafts and Substitutes Material Type Outlook (Revenue, USD Million, 2016-2028)


  • Natural
  • Synthetic

Bone Grafts and Substitutes Application Type Outlook (Revenue, USD Million, 2016-2028)


  • Spinal Fusion
  • Craniomaxillofacial
  • Long Bone

Bone Grafts and Substitutes Regional Outlook (Revenue, USD Million, 2016-2028)


  • North America
  • U.S.
  • Canada
  • Europe
  • UK
  • Germany
  • France
  • Italy
  • Russia
  • Asia Pacific
  • India
  • Japan
  • China
  • South Korea
  • Latin America
  • Brazil
  • Mexico
  • Colombia
  • Middle East & Africa
  • Saudi Arabia
  • South Africa
  • Israel
  • UAE
Frequently Asked Questions about the Bone Grafts and Substitutes Market

What is the estimated value of the Bone Grafts and Substitutes Market?

The Bone Grafts and Substitutes Market was estimated to be valued at $2.92 Billion in 2021.

What is the growth rate of the Bone Grafts and Substitutes Market?

The growth rate of the Bone Grafts and Substitutes Market is 8.0%, with an estimated value of $5.26 Billion by 2028.

What is the forecasted size of the Bone Grafts and Substitutes Market?

The Bone Grafts and Substitutes Market is estimated to be worth $5.26 Billion by 2028.

Who are the key companies in the Bone Grafts and Substitutes Market?

Key companies in the Bone Grafts and Substitutes Market include Orthofix Holdings Inc., DePuy Synthes, Medtronic PLC, Stryker Corp and AlloSource Inc.

Table of Contents

1. Overview and Scope
1.1. Research goal & scope
1.2. Research assumptions
1.3. Research Methodology
1.3.1. Primary data sources
1.3.2. Secondary data sources
1.4. Key take-aways
1.5. Stakeholders
2. Executive Summary
2.1. Market Definition
2.2. Market Segmentation
3. Bone Grafts and Substitutes Market Insights
3.1. Bone Grafts and Substitutes – Industry snapshot
3.2. Bone grafts and substitutes market dynamics
3.2.1. Bone Grafts and Substitutes – Market Forces
3.2.1.1. Bone Grafts and Substitutes Market driver analysis
3.2.1.2. Bone Grafts and Substitutes Market restraint/challenges analysis
3.2.1.3. Bone Grafts and Substitutes Market opportunity analysis
3.3. Industry analysis - Porter's five force
3.3.1. Bargaining power of supplier
3.3.2. Bargaining power of buyer
3.3.3. Threat of substitute
3.3.4. Threat of new entrant
3.3.5. Degree of competition
3.4. Bone grafts and substitutes market PEST analysis
3.5. Value Chain Analysis
3.6. Competitive Ranking Analysis, 2020
3.7. COVID-19 Impact Analysis
4. Bone Grafts and Substitutes Market Size and Forecast by Material type
4.1. Global Bone grafts and substitutes market share by material type, 2020 & 2028
4.2. Natural
4.2.1. Global natural Bone grafts and substitutes market estimates and forecasts, 2016 - 2028 (USD Million)
4.2.2. Global natural Bone grafts and substitutes market estimates and forecasts, by region, 2016 - 2028 (USD Million)
4.3. Synthetic
4.3.1. Global synthetic Bone grafts and substitutes market estimates and forecasts, 2016 - 2028 (USD Million)
4.3.2. Global synthetic Bone grafts and substitutes market estimates and forecasts, by region, 2016 - 2028 (USD Million)
5. Bone Grafts and Substitutes Market Size and Forecast by Application
5.1. Global Bone grafts and substitutes market share by application, 2020 & 2028
5.2. Spinal Fusion
5.2.1. Global Bone grafts and substitutes market estimates and forecasts for spinal fusion, 2016 - 2028 (USD Million)
5.2.2. Global Bone grafts and substitutes market estimates and forecasts for spinal fusion, by region, 2016 - 2028 (USD Million)
5.3. Craniomaxillofacial
5.3.1. Global Bone grafts and substitutes market estimates and forecasts for craniomaxillofacial, 2016 - 2028 (USD Million)
5.3.2. Global Bone grafts and substitutes market estimates and forecasts for craniomaxillofacial, by region, 2016 - 2028 (USD Million)
5.4. Long Bone
5.4.1. Global Bone grafts and substitutes market estimates and forecasts for long bone, 2016 - 2028 (USD Million)
5.4.2. Global Bone grafts and substitutes market estimates and forecasts for long bone, by region, 2016 - 2028 (USD Million)
6. Bone grafts and substitutes Market Size and Forecast by Region
6.1. Global bone grafts and substitutes market share by region, 2020 & 2028
6.2. North America
6.2.1. North America bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.2.2. North America bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.2.3. U.S.
6.2.3.1. U.S. bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.2.3.2. U.S. bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.2.4. Canada
6.2.4.1. Canada bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.2.4.2. Canada bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3. Europe
6.3.1. Europe bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.2. Europe bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3.3. Germany
6.3.3.1. Germany bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.3.2. Germany bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3.4. UK
6.3.4.1. UK bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.4.2. UK bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3.5. France
6.3.5.1. France bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.5.2. France bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3.6. Italy
6.3.6.1. Italy bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.6.2. Italy bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.3.7. Russia
6.3.7.1. Russia bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.3.7.2. Russia bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.4. Asia Pacific
6.4.1. Asia Pacific bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.4.2. Asia Pacific bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.4.3. China
6.4.3.1. China bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.4.3.2. China bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.4.4. South Korea
6.4.4.1. South Korea bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.4.4.2. South Korea bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.4.5. Japan
6.4.5.1. Japan bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.4.5.2. Japan bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.4.6. India
6.4.6.1. India bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.4.6.2. India bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.5. Latin America
6.5.1. Latin America bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.5.2. Latin America bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.5.3. Brazil
6.5.3.1. Brazil bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.5.3.2. Brazil bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.5.4. Mexico
6.5.4.1. Mexico bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.5.4.2. Mexico bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.5.5. Colombia
6.5.5.1. Colombia bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.5.5.2. Colombia bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.6. Middle East & Africa
6.6.1. MEA bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.6.2. MEA bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.6.3. Saudi Arabia
6.6.3.1. Saudi Arabia bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.6.3.2. Saudi Arabia bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.6.4. South Africa
6.6.4.1. South Africa bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.6.4.2. South Africa bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.6.5. Israel
6.6.5.1. Israel bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.6.5.2. Israel bone grafts and substitutes market by application type (USD Million), 2016 - 2028
6.6.6. UAE
6.6.6.1. UAE bone grafts and substitutes market by material type (USD Million), 2016 - 2028
6.6.6.2. UAE bone grafts and substitutes market by application type (USD Million), 2016 - 2028
7. Company Profiles
7.1. Orthofix Holdings, Inc
7.1.1. Overview
7.1.2. Financials
7.1.3. Product Benchmarking
7.1.4. Recent Developments
7.2. DePuy Synthes, Inc.
7.2.1. Overview
7.2.2. Financials
7.2.3. Product Benchmarking
7.2.4. Recent Developments
7.3. Medtronic PLC
7.3.1. Overview
7.3.2. Financials
7.3.3. Product Benchmarking
7.3.4. Recent Developments
7.4. Stryker Corp
7.4.1. Overview
7.4.2. Financials
7.4.3. Product Benchmarking
7.4.4. Recent Developments
7.5. Nuvasive, Inc
7.5.1. Overview
7.5.2. Financials
7.5.3. Product Benchmarking
7.5.4. Recent Developments
7.6. AlloSource, Inc.
7.6.1. Overview
7.6.2. Financials
7.6.3. Product Benchmarking
7.6.4. Recent Developments
7.7. Smith & Nephew, Inc.
7.7.1. Overview
7.7.2. Financials
7.7.3. Product Benchmarking
7.7.4. Recent Developments
7.8. Baxter
7.8.1. Overview
7.8.2. Financials
7.8.3. Product Benchmarking
7.8.4. Recent Developments
7.9. Wright Medical Group N.V.
7.9.1. Overview
7.9.2. Financials
7.9.3. Product Benchmarking
7.9.4. Recent Developments
7.10. OST Développement
7.10.1. Overview
7.10.2. Financials
7.10.3. Product Benchmarking
7.10.4. Recent Developments
7.11. Zimmer Biomet
7.11.1. Overview
7.11.2. Financials
7.11.3. Product Benchmarking
7.11.4. Recent Developments
7.12. Geistlich Pharma AG
7.12.1. Overview
7.12.2. Financials
7.12.3. Product Benchmarking
7.12.4. Recent Developments
7.13. TBF Tissue Engineering
7.13.1. Overview
7.13.2. Financials
7.13.3. Product Benchmarking
7.13.4. Recent Developments
7.14. Biobank
7.14.1. Overview
7.14.2. Financials
7.14.3. Product Benchmarking
7.14.4. Recent Developments
List of Tables
Table 1. Global bone grafts and substitutes market 2016 - 2028, (USD Million)
Table 2. Global bone grafts and substitutes market by region 2016 - 2028, (USD Million)
Table 3. Global bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 4. Global bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 5. Natural bone grafts and substitutes market, 2016 - 2028, (USD Million)
Table 6. Natural bone grafts and substitutes market, by region, 2016 - 2028, (USD Million)
Table 7. Synthetic bone grafts and substitutes market, 2016 - 2028, (USD Million)
Table 8. Synthetic bone grafts and substitutes market, by region, 2016 - 2028, (USD Million)
Table 9. Global bone grafts and substitutes market estimates and forecasts for spinal fusion, 2016 - 2028, (USD Million)
Table 10. Global bone grafts and substitutes market estimates and forecasts for spinal fusion, by region, 2016 - 2028, (USD Million)
Table 11. Global bone grafts and substitutes market estimates and forecasts for craniomaxillofacial, 2016 - 2028, (USD Million)
Table 12. Global bone grafts and substitutes market estimates and forecasts for craniomaxillofacial, by region, 2016 - 2028, (USD Million)
Table 13. Global bone grafts and substitutes market estimates and forecasts for long bone, 2016 - 2028, (USD Million)
Table 14. Global bone grafts and substitutes market estimates and forecasts for long bone, by region, 2016 - 2028, (USD Million)
Table 15. North America bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 16. North America bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 17. U.S. bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 18. U.S. bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 19. Canada bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 20. Canada bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 21. Europe bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 22. Europe bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 23. Germany bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 24. Germany bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 25. UK bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 26. UK bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 27. France bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 28. France bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 29. Italy bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 30. Italy bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 31. Russia bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 32. Russia bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 33. Asia Pacific bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 34. Asia Pacific bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 35. China bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 36. China bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 37. India bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 38. India bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 39. Japan bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 40. Japan bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 41. South Korea bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 42. South Korea bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 43. Latin America bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 44. Latin America bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 45. Brazil bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 46. Brazil bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 47. Mexico bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 48. Mexico bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 49. Colombia bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 50. Colombia bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 51. MEA bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 52. MEA bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 53. Saudi Arabia bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 54. Saudi Arabia bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 55. Israel bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 56. Israel bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 57. UAE bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 58. UAE bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
Table 59. South Africa bone grafts and substitutes market by material type, 2016 - 2028, (USD Million)
Table 60. South Africa bone grafts and substitutes market by application type, 2016 - 2028, (USD Million)
List of Figures
Figure 1. Market snapshot
Figure 2. Market segmentation & scope
Figure 3. Global Bone grafts and substitutes market size and growth prospects, 2016 – 2028
Figure 4. Value chain analysis
Figure 5. Bone grafts and substitutes market dynamics
Figure 6. Key market opportunities - prioritized
Figure 7. Industry analysis – Porter’s
Figure 8. PESTEL analysis
Figure 9. Global Bone grafts and substitutes market share by material type, 2020 & 2028
Figure 10. Global Bone grafts and substitutes market share by application type, 2020 & 2028
Figure 11. Global Bone grafts and substitutes market share by region, 2020 & 2028
Figure 12. Competitive environment
Figure 13. Strategy framework

Companies Mentioned

  • Orthofix Holdings Inc.
  • DePuy Synthes
  • Medtronic PLC
  • Stryker Corp
  • Nuvasive Inc.
  • AlloSource Inc