The Next Generation Sequencing (NGS) Markets in China

1. Market Overview

NGS Workflow and Leading Products in the Market

• Library Preparation and Amplification
• Sequencing
• Data Analysis    

NGS Market Trends    

• Market Drivers    
  • Technological Advancements
  • Declining Costs
  • Precision Medicine Focus
  • Increasing Demand from Clinical Applications Segments
  • Growing Investments in Companion Diagnostics (CDX) Development
  
  
• Market Restraints    
  • High Costs Compared to Alternative Genomic Platforms    
  • Lack of Effective Software Solutions for Data Management and Downstream Analysis    
  • NGS Data Management, Interpretation and Sharing: Ethical and Legal Issues    
  • Lack of Geneticists    
  
  

Influence of China’s Regulatory Landscape on Its NGS Market    

• Government Initiatives Relevant for NGS Market    
  • Five-Year Plans (FYP)    
  • Healthy China 2030 (HC 2030)    
  • Investments for Genome Databases    
  • Made in China 2025    
  
  
• Regulations and Expert Consensus on Genetic Testing in China    
• Table 1: Regulatory Agencies Relevant for Genetic Testing    
• Table 2: Approval of NGS-Based Diagnostics: Regulatory Agencies Involved    
• Regulatory Pathways Relevant for NGS-Based Diagnostic Products    
• Genomic Material and Genomic Data Sharing Policy of China    
• Table 3: Highlights of the Human Genetic Resources Regulation in China Relevant for Foreign Organizations and Collaborators    
• Lab Developed Tests (LDTS)    
• Independent Clinical Laboratories (Icls) Offering NGS Services    
• Table 4: Regulatory Requirements for Clinical Genetic Testing Services    
• Negative List    
• Regulatory Pathway for CDX    
• Table 5:  Regulatory Guidelines Relevant for CDX by Nmpa    

Health Insurance Landscape in China and Its Influence on NGS Market    

• Social Health Insurance Schemes in China    
• Table 6. The Social Health Insurance Schemes (SHIS) in China.    
• Private Health Insurance    
• Insurance for Genome Sequencing Services    
  • Partnerships Between Insurance Companies and NGS Test Service Providers    
  
  
• The NGS Market Landscape in China    
  • Partnerships Focusing on NGS Platforms and Assays    
  
  

NGS Market Size and Growth Forecasts    

• Table 7: the NGS Market Size and Forecast in China (USD, Million)    

2. NGS Markets in China by Methods    

Targeted Genome Sequencing and Resequencing    

• Table 8: Selected List of NGS-Based Gene Panel Tests for Clinical Diagnostics in China    

Whole Genome Sequencing (WGS)    

• WGS-Based Clinical Diagnostics Tests in China    
• Large-Scale WGS Studies in China    
• Table 9: Selected List of Large-Scale WGS Projects in China    

Whole Exome Sequencing (Wes)    

RNA-Seq    

• RNA-Seq: An Assessment of the Global Market Trends    
• Table 10: Selected List of Companies Offering RNA-Seq Library Preparation Kits    
  • mRNA-Seq    
  • Non-Coding RNA-Seq    
  • Single-Cell RNA-Seq (SCRNA-Seq)    
  
  
• Table 11: Selected List of the Cell Isolation and Library Preparation Platforms for SCRNA-Seq    
• Table 12: Selected List of SCRNA-Seq Data Analysis Products    
• Growth of RNA-Seq Demand in China    
• Table 13: RNA-Seq Demand for Research in China (2017-2021)    
• Transcriptomics Moving from Microarrays to RNA-Seq    

Other NGS Methods    

The Market Size and Growth Trends of the Leading NGS Methods    

• Table 14: the NGS Market Size and Forecast in China by Method (USD, Million)    

3. NGS Markets in China by Products and Services    

Instruments    

• Single Cell Sequencing    
• Table 15: Popular NGS Platforms in the Chinese Market    
• Emergence Domestic Gene Sequencers Challenge Existing OEM Models    
  • NGS Systems Demand Growing in China’s Hospital Segment Triggered by Covid-19    
  
  
• NGS Workflow Automation Products    
• Table 16: Selected List of Vendors Facilitating NGS Automation in China    

Consumables and Accessories    

• Table 17: Selected List of NGS Library Preparation Products for Research Use    

Bioinformatics Tools for NGS    

• Primary Data Analysis    
• Secondary Data Analysis    
• Tertiary Data Analysis    
• Table 18: Commonly Used Bioinformatic Tools for NGS: for Primary, Secondary, and Tertiary Data Analysis    
  • Role of Cloud Computing    
  • Key Challenges of NGS Data Analysis Players    
    • High Costs    
    • PCR Amplification Bias    
    • Data Confidentiality Concerns    
    • Translation of Data into Actionable Insights    
    • Integration of Data for Comparison With Results Derived from Different Platforms    
    
    
  • The Growing NGS Data Analysis Demand for Clinical Diagnostics in China    
  • NGS Data Analysis in China: Activities of Key Players    
  
  
• NGS Service Providers in China    
• Table 19: Selected List of Leading NGS Service Providers in China    

NGS Market Size and Growth Trends in China by Products and Services    

• Table 20: the NGS Market Size and Forecasts in China by Products and Services (USD, Million)    

4. NGS Markets in China by Application Segments    

Clinical Diagnostics    

• Oncology    
• Table 21: Leading Cancer Types in China: Incidences & Deaths    
  • Cancer Survival Rates in China    
  • Government Initiatives for Cancer Prevention in China    
  
  
• Table 22: Selected List of Cancer Prevention and Control Measures in China    
  • Healthy China Program (2019-30): Focus on Cancer    
  • Challenges of Implementing Cancer Prevention Strategies in China    
  • Genetic Testing in Oncology Sector: Prescription Trends    
  • Regulations Influencing NGS-Based Cancer Diagnosis in China    
  
  
• Table 23: Selected List of Medical Associations That Influence Cancer Diagnostics Guidelines in China    
  • NGS-Based CDX Tests for Cancer in China: Regulations and Expert Consensus    
    • Guidelines for Restricted Use Drugs and Related CDX    
    
    
  • NGS-Based Cancer Diagnostics: An Overview of the Global Market    
  • The Role of NGS in China’s Cancer Diagnostics    
  
  
• Table 24: Molecular Diagnostics Platforms Used for Companion Diagnostics for Different Cancer Therapies    
• Table 25: NGS- Based Cancer Companion Diagnostics Approved by China’s NMPA    
  • The Growing Demand for Gene Panel Tests for Cancer Diagnostics    
  • The Prospects for NGS-Based Early Tumor Screening in China
  • NGS as a Complimentary Platform
  • Leading NGS Players in China’s Oncology Sector and Their Revenue Models    
    • Comparison of the Revenue Models of Burning Rock, Amoy Diagnostics, and Berry Genomics    
    
    
  • Partnerships of Global Players With Domestic Companies    
  
  
• Table 26: NGS-Based Cancer Diagnostics in China: Partnerships Between Global Players and Domestic Companies    
  • NGS Demand for Cancer Diagnostics in China: Market Trends    
  
  
• Reproductive Health Diagnostics    
  • The Rising Global Demand for NIPT    
  
  
• Table 27: Typical Diseases and Aneuploidies Tested by NIPT Assays    
• Table 28: Selected List of NGS-Based NIPT Tests in the Global Market    
  • An Assessment of the Ip Landscape of NGS Platforms in the Global NIPT Market    
  • The Ip Landscape of NIPT in China    
  • Rising Investments in the New-Born and Prenatal Testing Markets    
  • Prenatal Testing Insurance Coverage Status: China Vs Other Leading Markets    
  • Regulations Influencing the NGS Demand in Reproductive Health Diagnostics    
    • Regulations on New-Born and Prenatal Testing    
    • Regulations on Preimplantation Genetic Testing (PGT)    
    
    
  • Reproductive Health Diagnostics Market Trends in China    
    • The Growing Demand for NGS-Based NIPT    
    • The Emerging Preimplantation Genetic Testing (PGT) Segment in China    
    • New-Born Testing and Carrier Screening Segments: Opportunities for NGS Players in China    
      • New-Born Testing    
      • Carrier Screening    
      
      
    • Collaborations and Partnerships in the Reproductive Health Diagnostics Segments    
    
    
  
  
• Table 29: Selected List of Partnerships of NGS Companies in China in the Field of Reproductive Health Diagnostics    
  • Availability of NGS-Based Reproductive Health Tests    
  
  
• Table 30: Selected List of NGS-Based Reproductive Health Tests Available in China    
  • NGS Demand in Other Clinical Diagnostics Segments    
  • Infectious Diseases    
    • Covid-19 Testing    
    • Tuberculosis    
    
    
  • HLA Typing    
  • Hereditary Diseases    
  
  

Direct-To-Consumer Genetic Testing (DTC-GT) Application Segment    

• Alternative Regulatory Pathways: Trends in the Global as Well as China’s DTC-GT Markets    
  • An Assessment of the Legal Framework for DTC-GT in China    
  
  
• Table 31: the Evolving Regulatory Landscape Influencing China’s DTC-GT Market    
  • Informed Consent in China    
  
  
• Logistics Channels of DTC-GT in China    
• Revenue Generation Models: Global Market Trends Vs Emerging Models in China    
  • Lack of Genetic Counsellors Offering New Opportunities to Data Analysis Start-Ups    
  
  
• Key Focus Areas of DTC-GT in China    
  • Talent Screening    
  
  
• Status of DTC Genetic Testing in China    
• Table 32: Selected Players in China Offering DTC-GT Services    

NGS for Research Applications in China    

• Academic Research    
• Table 33: Selected List of Prominent Research Centres Active in NGS Research    
• Large-Scale Genome Projects in China    
• Table 34: Selected List of Large-Scale NGS-Based Genome Projects in China    
• Chinese Genome Databases    
• Table 35: Selected List of Organizations Developing Human Genome Databases in China    
• Industry R&D    
• Table 36: Selected List of Industry R&D Partnerships Signed by NGS Companies in China    

Other Emerging NGS Application Segments: Food Testing, Forensics, Etc.    

Market Size and Forecasts of NGS in Key Application Segments in China    

• Table 37: the NGS Market Size and Forecasts in China by Application Segments (2021-2026; USD, Million)    

5. Company Profiles    

10X Genomics, Inc    

• Products and Services    
• Table 38: Selected List of NGS Products Offered by 10X Genomics    
• Response to Covid-19 Pandemic    
• Acquisitions and Partnerships    
• Table 39: Selected List of Partnerships and Acquisitions of 10X Genomics    
• Activities in the China Market    

23Mofang    

Adicon (Hangzhou Adicon Clinical Laboratories, Inc.)    

• Table 40: the List of Cities Under the Service Network of Adicon    
• Activities in the NGS Field    
• Table 41: a Selected List of NGS Services Offered by Adicon    

Agilent Technologies    

• NGS Products Offered by Agilent Technologies    
• Partnerships and Collaborations    
• Table 42: Selected List of Partnerships of Agilent Technologies in the Last 5 Years    
• Impact of Covid-19 on Agilent’S NGS Business    
• Activities in China’S NGS Market    

Amoy Diagnostics Co Ltd.    

• Products and Services Offered by Amoydx    
• Table 43: Selected Assays and Services Offered by Amoydx    
• Collaborations/Partnerships    
• Table 44: Selected List of Collaborations Signed by Amoydx    
• Response to Covid-19 Pandemic    

Annoroad Gene Technology Beijing Co Ltd    

• Activities in the NGS Field    

Basecare Medical (Suzhou Basecare Medical Device Co. Ltd.)    

• An Emerging Art Solutions Provider    

Berry Genomics Co Ltd    

• Investments and Collaborations    
• Table 45: Selected List of Partnership Agreements Signed by Berry Genomics    
• Sequencing Services Offered by Berry Genomics    
• Table 46: NGS Platforms Used for Offering Sequencing Services by Berry Genomics    
• Assays and Services Offered by Berry Genomics    
• Table 47: Assays and Services Offered by Berry Genomics    
• Response to Covid-19 Pandemic    

BGI Group    

• BGI Genomics Co Ltd and MGI Tech    
• Table 48: Sequencers Produced and Marketed by the BGI Group    
• Table 49: NGS-Based Assays and Services Provided by BGI Group    
• Partnerships and Collaborations    
• Table 50 : Selected List of Partnerships BGI Group*    
• Response to Covid-19    

Burning Rock Medical    

• Table 51: Selected List of Collaborations of Burning Rock Related to the NGS Market    

Capitalbio Corporation    

• Activities in the NGS Market    
  • Capitalbio Technology Co. Ltd (Capitalbio Tech)    
  
  
• Table 52: Selected List of NGS Services Offered by Capitalbio Tech    
  • Capitalbio Genomics Co. Ltd. (Capitalbio Genomics)    
  
  
• Table 53: Selected List of NGS Services Offered by Capitalbio Genomics    
  • Capitalbio Diagnostic Laboratory (Capitalbio Diagnostic)    
  
  
• Table 54: the Service Network of Capitalbio Diagnostic Across China    
• Table 55: Selected List of NGS-Based Clinical Testing Services Offered by Capitalbio Diagnostics    

Da An Gene Co. Ltd.    

• Guangzhou Darui Biotechnology Co. Ltd. (Darui Biotech；达瑞生物)    
• Table 56: Selected List of NGS-Based Tests Offered by Darui Biotech    

Dian Diagnostics Group Co. Ltd.    

• Table 57: the List of Provinces in China Covered Under the Service Network of Dian    
• NGS-Based Business Activities    
• Table 58: Selected List of NGS Services Offered by Dian    

Geneseeq Technology Inc    

• Products and Services    
• Table 59: Selected List of NGS-Based Assays and Services Offered by Geneseeq Technology    
• Collaborations/Partnerships    
• Response to Covid-19 Pandemic    

Genetron Health (Beijing) Co. Ltd    

• Table 60: Funding Raised by Genetron Health    
• Collaborations and Partnerships    
• Products & Services    
• Table 61: Selected List of NGS-Based Products of Genetron Health    

Haplox Biotechnology    

• Partnerships and Collaborations    
• Products and Services Offered by Haplox    

Jellyfish Gene (Beijing Jellyfish Technology Co. Ltd.)    

Kingmed Diagnostics (Guangzhou Kingmed Diagnostics Group Co. Ltd.)    

• Table 62: the List of Cities Under the Service Network of Kingmed    
• Business Activities in the Field of NGS    
• Table 63: Selected List of NGS Services Offered by Kingmed    

Illumina    

• Expanding Consumer Segments    
• NGS Business – Strategies, Products, and Services    
• Table 64: Selected List of Sequencing Systems Offered by Illumina    
• Table 65: Selected List of Assays Offered by Illumina    
• Response to Covid-19 Pandemic    
• Focus on Innovation and Related Investments    
• Clinical Diagnostics Strategies    
• Table 66: Selected List of Partnerships Targeting Diagnostics Applications    
• Activities in China’S NGS Market    
  • Collaborations With China-Based Companies    
  
  
• Table 67: Selected List of Partners of Illumina in the Field of Clinical Diagnostics in China    

Novogene Co. Ltd.    

• Table 68: Novogene’S Service Network in China    
• Table 69: NGS-Based Services for Research Applications Offered by Novogene    

Oxford Nanopore Technologies    

• Table 70: Sequencers Offered by Oxford Nanopore Technologies    
• Response to Covid-19 Pandemic    
• Partnerships and Collaborations    
• Table 71: Selected List of Recent Partnerships of Oxford Nanopore Technologies    
• Activities in the Chinese Market    

Pacific Biosciences    

• Table 72: Selected List of the Products Offered by Pacbio    
• Partnerships and Collaborations    
• Table 73: Selected List of Partnerships of Pacbio    
• Impact of Covid-19 Pandemic    
• Activities in China’S NGS Market    

Qi Carbon Technology Co Ltd (Qc Technology)    

• Collaborations/Partnerships    
• Technology Offered by Qc Technology    
• Table 74: Nanopore Gene Sequencing Technology Products Offered by Qc Technology    
• Response to Covid-19 Pandemic    

Spacegen (Xiamen Spacegen Co. Ltd.)    

Thermo Fisher Scientific Inc.    

• Response to Covid-19 Pandemic    
• Partnerships and Acquisitions    
• Table 75: Selected Partnerships and Acquisitions of Thermo Fisher (2017-2020)    
• NGS Products and Services    
• Table 76: NGS Instruments Offered by Thermo Fisher Scientific    
• Table 77: Selected List of NGS-Based Assays and Services of Thermo Fisher Scientific    
• Thermo Fisher Scientific in China’S NGS Market    

Tiangen Biotech Co. Ltd.    

• Response to Covid-19 Pandemic    
• Tiangen Biotech NGS Portfolio    

Transgen Biotech (Beijing Transgen Biotech Co. Ltd.)    

• Response to Covid-19 Pandemic    

Turtle Technology (Shanghai Turtle Technology Co. Ltd.)    

Wegene    

• Collaborations/Partnerships    
• Table 78: Selected List of Collaborations Signed by Wegene    
• Assays and Services Offered by Wegene    
• Table 79: Selected List of Assays and Services Offered by Wegene    

Zhongke Zixin (Beijing Zhongke Zixin    Technology Co. Ltd.)    

6. Glossary    

7. Disclaimer    

List of Tables

Table 1: Regulatory Agencies Relevant for Genetic Testing    
Table 2: Approval of NGS-Based Diagnostics: Regulatory Agencies Involved    
Table 3: Highlights of the Human Genetic Resources Regulation in China Relevant for Foreign Organizations and Collaborators    
Table 4: Regulatory Requirements for Clinical Genetic Testing Services    
Table 5:  Regulatory Guidelines Relevant for CDX by NMPA    
Table 6: the Social Health Insurance Schemes (SHIS) in China.    
Table 7: the NGS Market Size and Forecast in China (USD, Million)    
Table 8: Selected List of NGS-Based Gene Panel Tests for Clinical Diagnostics in China    
Table 9: Selected List of Large-Scale WGS Projects in China    
Table 10: Selected List of Companies Offering RNA-Seq Library Preparation Kits    
Table 11: Selected List of the Cell Isolation and Library Preparation Platforms for SCRNA-Seq    
Table 12: Selected List of SCRNA-Seq Data Analysis Products    
Table 13: RNA-Seq Demand for Research in China (2017-2021)    
Table 14: the NGS Market Size and Forecast in China by Method (USD, Million)    
Table 15: Popular NGS Platforms in the Chinese Market    
Table 16: Selected List of Vendors Facilitating NGS Automation in China    
Table 17: Selected List of NGS Library Preparation Products for Research Use    
Table 18: Commonly Used Bioinformatic Tools for NGS: for Primary, Secondary, and Tertiary Data Analysis    
Table 19: Selected List of Leading NGS Service Providers in China    
Table 20: the NGS Market Size and Forecasts in China by Products and Services (USD, Million)    
Table 21: Leading Cancer Types in China: Incidences & Deaths    
Table 22: Selected List of Cancer Prevention and Control Measures in China    
Table 23: Selected List of Medical Associations That Influence Cancer Diagnostics Guidelines in China    
Table 24: Molecular Diagnostics Platforms Used for Companion Diagnostics for Different Cancer Therapies    
Table 25: NGS- Based Cancer Companion Diagnostics Approved by China’S Nmpa    
Table 26: NGS-Based Cancer Diagnostics in China: Partnerships Between Global Players and Domestic Companies    
Table 27: Typical Diseases and Aneuploidies Tested by NIPT Assays    
Table 28: Selected List of NGS-Based NIPT Tests in the Global Market    
Table 29: Selected List of Partnerships of NGS Companies in China in the Field of Reproductive Health Diagnostics    
Table 30: Selected List of NGS-Based Reproductive Health Tests Available in China    
Table 31: the Evolving Regulatory Landscape Influencing China’S DTC-GT Market    
Table 32: Selected Players in China Offering DTC-GT Services    
Table 33: Selected List of Prominent Research Centres Active in NGS Research    
Table 34: Selected List of Large-Scale NGS-Based Genome Projects in China    
Table 35: Selected List of Organizations Developing Human Genome Databases in China    
Table 36: Selected List of Industry R&D Partnerships Signed by NGS Companies in China    
Table 37: the NGS Market Size and Forecasts in China by Application Segments (2021-2026; USD, Million)    
Table 38: Selected List of NGS Products Offered by 10X Genomics    
Table 39: Selected List of Partnerships and Acquisitions of 10X Genomics    
Table 40: the List of Cities Under the Service Network of Adicon    
Table 41: a Selected List of NGS Services Offered by Adicon    
Table 42: Selected List of Partnerships of Agilent Technologies in the Last 5 Years    
Table 43: Selected Assays and Services Offered by Amoydx    
Table 44: Selected List of Collaborations Signed by Amoydx    
Table 45: Selected List of Partnership Agreements Signed by Berry Genomics    
Table 46: NGS Platforms Used for Offering Sequencing Services by Berry Genomics    
Table 47: Assays and Services Offered by Berry Genomics    
Table 48: Sequencers Produced and Marketed by the BGI Group    
Table 49: NGS-Based Assays and Services Provided by BGI Group    
Table 50: Selected List of Partnerships BGI Group*    
Table 51: Selected List of Collaborations of Burning Rock Related to the NGS Market    
Table 52: Selected List of NGS Services Offered by Capitalbio Tech    
Table 53: Selected List of NGS Services Offered by Capitalbio Genomics    
Table 54: the Service Network of Capitalbio Diagnostic Across China    
Table 55: Selected List of NGS-Based Clinical Testing Services Offered by Capitalbio Diagnostics    
Table 56: Selected List of NGS-Based Tests Offered by Darui Biotech    
Table 57: the List of Provinces in China Covered Under the Service Network of Dian    
Table 58: Selected List of NGS Services Offered by Dian    
Table 59: Selected List of NGS-Based Assays and Services Offered by Geneseeq Technology    
Table 60: Funding Raised by Genetron Health    
Table 61: Selected List of NGS-Based Products of Genetron Health    
Table 62: the List of Cities Under the Service Network of Kingmed    
Table 63: Selected List of NGS Services Offered by Kingmed    
Table 64: Selected List of Sequencing Systems Offered by Illumina    
Table 65: Selected List of Assays Offered by Illumina    
Table 66: Selected List of Partnerships Targeting Diagnostics Applications    
Table 67: Selected List of Partners of Illumina in the Field of Clinical Diagnostics in China    
Table 68: Novogene’S Service Network in China    
Table 69: NGS-Based Services for Research Applications Offered by Novogene    
Table 70: Sequencers Offered by Oxford Nanopore Technologies    
Table 71: Selected List of Recent Partnerships of Oxford Nanopore Technologies    
Table 72: Selected List of the Products Offered by Pacbio    
Table 73: Selected List of Partnerships of Pacbio    
Table 74: Nanopore Gene Sequencing Technology Products Offered by Qc Technology    
Table 75: Selected Partnerships and Acquisitions of Thermo Fisher (2017-2020)    
Table 76: NGS Instruments Offered by Thermo Fisher Scientific    
Table 77: Selected List of NGS-Based Assays and Services of Thermo Fisher Scientific    
Table 78: Selected List of Collaborations Signed by Wegene    
Table 79: Selected List of Assays and Services Offered by Wegene