TIE-2 receptor agonists - Pipeline Insight, 2024

This “TIE-2 receptor agonists - Pipeline Insight, 2024” report provides comprehensive insights about 4+ companies and 6+ pipeline drugs in TIE-2 receptor agonists pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

TIE-2 receptor agonists Understanding

TIE-2 receptor agonists: Overview

The tie receptors form another family of receptor tyrosine kinases. They are important for the regulation of angiogenesis together with the ligands of the tie-2 receptor, the Angiopoietins. The tie tyrosine kinase receptors, like the VEGF receptors, form the only receptor families that are predominantly expressed on endothelial cells. Most studies have focused on Ang-1 and Ang-2 which bind the Tie2 receptor and have the best characterized roles in angiogenesis. The roles of Ang-1 and Ang-2 signaling are complex and context dependent. Ang-1 binds and directly activates the Tie2 receptor, and this can have pro-angiogenic roles, stimulating EC sprouting and vessel growth as well as being correlated with vessel density in a variety of tumors.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence TIE-2 receptor agonists R&D. The therapies under development are focused on novel approaches for TIE-2 receptor agonists.

TIE-2 receptor agonists Emerging Drugs Chapters

This segment of the TIE-2 receptor agonists report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

TIE-2 receptor agonists Emerging Drugs

AV-001: Vasomune TherapeuticsAV-001, a synthetic Angiopoietin 1 mimetic, activates the Tie2 receptor which is highly expressed on the surface of endothelial cells located within the vasculature.. AV-001 is designed to interact with the Tie2 receptor on a binding domain distinct from the natural ligands Angiopoietin 1 and Angiopoietin 2. Activation of Tie2 broadly promotes barrier defense against vascular leak and counteracts vascular inflammation by decreasing the activity of multiple pro-inflammatory factors. AV-001 represents a novel multifactorial approach that acts at the cellular and tissue-level. This approach is in contrast to the traditional highly specific lock and key therapies aimed at killing the pathogen or individual targets within the inflammatory response pathway. There are no clinically available medications to treat vascular leak.

Razuprotafib: Aadi BiosciencesRazuprotafib binds to and inhibits vascular endothelial protein tyrosine phosphatase (VE-PTP), an important negative regulator of Tie2. Decreased Tie2 activity contributes to vascular instability in many diseases including diabetes and more recently has been shown to contribute to the development of increased IOP and glaucoma. Razuprotafib activates the Tie2 receptor irrespective of extracellular levels of its binding ligands, angiopoietin-1 (agonist) or angiopoietin-2 (antagonist) and we believe that it may be the most efficient pharmacologic approach to maintain normal Tie2 activation. Aerpio is studying a topical ocular formulation of razuprotafib in open angle glaucoma and exploring the utility of subcutaneous razuprotafib for diabetic complications, including diabetic nephropathy. In addition, a subcutaneous formulation of razuprotafib is being explored for its therapeutic potential in treating or preventing ARDS associated with COVID-19.

TIE-2 receptor agonists: Therapeutic Assessment

This segment of the report provides insights about the different TIE-2 receptor agonists drugs segregated based on following parameters that define the scope of the report, such as:

Major Players working on TIE-2 receptor agonists

There are approx. 4+ key companies which are developing the TIE-2 receptor agonists. The companies which have their TIE-2 receptor agonists drug candidates in the most advanced stage, i.e. Phase II include, Aadi Biosciences.

Phases

This report covers around 6+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

TIE-2 receptor agonists pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Infusion
• Intradermal
• Intramuscular
• Intranasal
• Intravaginal
• Oral
• Parenteral
• Subcutaneous
• Topical

Molecule Type

Products have been categorized under various Molecule types such as

• Vaccines
• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

TIE-2 receptor agonists: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses TIE-2 receptor agonists therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging TIE-2 receptor agonists drugs.

TIE-2 receptor agonists Report Insights

• TIE-2 receptor agonists Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

TIE-2 receptor agonists Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing TIE-2 receptor agonists drugs?
• How many TIE-2 receptor agonists drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of TIE-2 receptor agonists?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the TIE-2 receptor agonists therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for TIE-2 receptor agonists and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• Aadi Biosciences
• Vasomune Therapeutics
• AsclepiX Therapeutics
• Q BioMed
• PharmAbcine
• Mannin Research

Key Products

• Razuprotafib
• AV 001
• Gersizangitide
• MAN 19
• PMC 403
• MAN 11
• ARP 1536

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