Proto oncogene protein c-myc inhibitors - Pipeline Insight, 2024

This “Proto oncogene protein c-myc inhibitors - Pipeline Insight, 2024” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Proto oncogene protein c-myc inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Proto oncogene protein c-myc inhibitors Understanding

Proto oncogene protein c-myc inhibitors: Overview

cMyc is a 62 kDa protein (439 amino acids) and belongs to the basic helix-loop-helix zipper (bHLHZip) class of transcription factors. cMyc has been implicated in multiple cellular processes, including proliferation, differentiation, apoptosis and metabolism. The four-helix structure of cMyc and MAX binds to DNA sequences, such as E-box motifs (5’-CACGTG -3’), to control transcription of specific genes. These genes have been reported to be involved in chromatin modification, DNA replication, and ribosome and mitochondrial biogenesis. A large number of proofs of principle experiments suggest that targeting cMyc may have considerable therapeutic benefit in human tumors. cMyc binds to the MAX protein and forms dimers, which are necessary for the biological activation of cMyc. Strategies have emerged to inhibit cMyc expression, to interrupt cMyc-Max dimerization, to inhibit cMyc-Max DNA binding, to interfere with key cMyc target genes, and to inhibit cMyc in cancer stem cells (CSCs).

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Proto oncogene protein c-myc inhibitors R&D. The therapies under development are focused on novel approaches for Proto oncogene protein c-myc inhibitors.

Proto oncogene protein c-myc inhibitors Emerging Drugs Chapters

This segment of the Proto oncogene protein c-myc inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Proto oncogene protein c-myc inhibitors Emerging Drugs

RRx-001: EpicentRx Inc.RRx-001 is a next generation, small molecule anticancer immunotherapeutic that downregulates the CD47/SIRPa axis and repolarizes TAMs and other immunosuppressive cells in the tumor microenvironment to an immunostimulatory phenotype. RRx-001 is designed to be used either as a monotherapy or in combination with chemotherapy, radiation therapy or immunotherapy. RRx-001 has Orphan Drug designation from FDA for SCLC, neuroendocrine cancer and glioblastoma, and from EMA for SCLC.

WP1066: Moleculin BiotechWP1066 is the company’s flagship Immune/Transcription Modulator. It has been the subject of over 50 peer-reviewed articles and its activity against p-STAT3 has now been validated in independent laboratories around the globe. WP1066 and other congeners (molecules similar in structure) in this portfolio have demonstrated in animal models the ability of this new class of agents to increase the natural immune response to tumor activity.

Proto oncogene protein c-myc inhibitors: Therapeutic Assessment

This segment of the report provides insights about the different Proto oncogene protein c-myc inhibitors drugs segregated based on following parameters that define the scope of the report, such as:

Major Players working on Proto oncogene protein c-myc inhibitors

There are approx. 15+ key companies which are developing the Proto oncogene protein c-myc inhibitors. The companies which have their Proto oncogene protein c-myc inhibitors drug candidates in the most advanced stage, i.e. Phase III include, EpicentRx.

Phases

This report covers around 15+ products under different phases of clinical development like

• Late-stage products (Phase III and
• Mid-stage products (Phase II and
• Early-stage products (Phase I/II and Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Proto oncogene protein c-myc inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Intravenous
• Oral
• Subcutaneous

Molecule Type

Products have been categorized under various Molecule types such as

• Peptides
• Small molecule

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Proto oncogene protein c-myc inhibitors: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Proto oncogene protein c-myc inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Proto oncogene protein c-myc inhibitors drugs.

Proto oncogene protein c-myc inhibitors Report Insights

• Proto oncogene protein c-myc inhibitors Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Proto oncogene protein c-myc inhibitors Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Scenario and Emerging Therapies:

• How many companies are developing Proto oncogene protein c-myc inhibitors drugs?
• How many Proto oncogene protein c-myc inhibitors drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Proto oncogene protein c-myc inhibitors?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Proto oncogene protein c-myc inhibitors therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Proto oncogene protein c-myc inhibitors and their status?
• What are the key designations that have been granted to the emerging drugs?

Key Players

• EpicentRx Inc.
• Moleculin Biotech
• Peptomyc
• Teva Pharmaceutical Industries
• Plexxikon
• CURACLE
• Aptose Biosciences
• Kintor Pharmaceutical
• Escend Pharmaceuticals
• Hillstream BioPharma

Key Products

• RRx-001
• WP1066
• OMO 103
• C41443
• PLX 51107
• CU 04
• APTO-253
• GT19077
• ES-4000
• HSB-510

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