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Global TIGIT Inhibitor Drug Opportunity & Clinical Research Insight 2022

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    Report

  • 120 Pages
  • December 2021
  • Region: Global
  • Kuick Research
  • ID: 5509206
UP TO OFF until Dec 31st 2022

Global TIGIT Inhibitor Drug Opportunity & Clinical Research Insight 2022 Report Highlights:

  • Global TIGIT Inhibitor Market Dynamics 
  • Clinical Approaches to Target TIGIT
  • Role of TIGIT Inhibitors in Cancer, HIV, Autoimmune Disorders
  • Number of TIGIT Inhibitor Drug In Trials
  • TIGIT Inhibitors Trials By Phase, Company, Country, Indication 
  • Clinical Trials Adverse Events  Scenario
  • Company Agreement/Partnership/Deals For Ongoing Trials
  • Global TIGIT Inhibitor Market Future Outlook

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is one of the most recently identified immune checkpoint inhibitor which is being evaluated as potential immunotherapeutic target. TIGIT is transmembrane glycoprotein receptor with Ig-like V-type domain and an ITIM in its cytoplasmic domain and is expressed on wide range of cells including memory T-cells, NK cells, and Tregs. Apart from this, studies have demonstrated high expression of TIGIT on wide range of solid tumors and hematological malignancies, thus making it potential target in drug development. 


Several pharmaceutical companies have developed a robust pipeline of TIGIT inhibitors in their pipeline indicated for the management of several cancers. Current clinical trials are mainly evaluating the role of TIGIT inhibitors in combination with PD-1/PD-L1 inhibitor or CTLA-4 inhibitors. Immunotherapy combinations featuring dual blockade of TIGIT and PD-1/PD-L1 are promising due to their synergistic enhancement of antitumor responses. More recently, Compugen in colloaboration with Bristol Meyer Squibb is evaluating triple combination of Opdivo, BMS-986207 (anti-TIGIT), and COM701 (anti-PVRIG). The preliminary data suggest that the triple combination was safe and well tolerated. 


Apart from cancer, researchers are also evaluating the role of novel immune checkpoint in other therapeutic conditions including HIV and autoimmune disorders. TIGIT has emerged out to be attractive target in HIV due to its expression on NK cells and almost all HIV-specific CD8+ T cells. Preclinical studies have favored the co-blockade of TIGIT with PD-1/PD-L1 inhibitor in HIV patients. The encouraging response from preclinical trials is expected to be translated in clinical studies in coming years. Further, researchers have also suggested the relationship between TIGIT expressing Treg cells and different autoimmune diseases including atopic dermatitis, autoimmune thyroiditis, type-1 diabetes, autoimmune uveitis, aplastic anemia, multiple sclerosis, systemic lupus erythematous, arthritis, and colitis. As of now, these studies are mainly confined to in-vivo and preclinical studies. 


Currently, the market for TIGIT inhibitor is mainly domination by therapeutic monoclonal antibodies. Several monoclonal antibodies targeting TIGIT have entered the clinical development including Tiragolumab, Ociperlimab, Vibostolimab, ASP-8374, and COM902. Further enhancement in the field of biotechnology and promising results of TIGIT inhibitor in combinational therapies have led to the development of novel bispecific constructs. Currently, a few bispecific antibodies including AGEN1777, IBI321 and HLX301 have entered initial stages of clinical trials. The emergence of bispecific antibody constructs is expected to show enhanced efficacy and will reduce the overall cost of therapy and drug development. 


Globally, there are more than 30 clinical trials ongoing which are evaluating novel anti-TIGIT antibodies in wide range of diseases. Some of the major indications which are anticipated to show a better outcome by the launch of these drugs include triple negative breast cancer, non-small cell lung cancer, colorectal cancer, melanoma, gastric cancer, and esophageal cancer. The global market is anticipated to show positive growth due to launch of TIGIT therapies during forthcoming years. Tiragolumab developed by Roche is leading drug candidate which has received priority review by US FDA and is expected to be launched in market by 2022. The emerging trend in TIGIT next generation immunotherapies with continuous headway movement along with the development of new technologies for the development of targeted therapies provides hope for better therapeutic alternatives in coming years. 


US will dominate the TIGIT Inhibitor development and commercialization landscape which is mainly attributed to large number of ongoing clinical trials in the region. Further, the high concentration of key players in the region which actively invest in research and development will also propel the growth of market. Beside US, China and South Korea will also emerge as key markets for TIGIT inhibitors drugs driven by increasing research and development activities.


Table of Contents

1. Introduction to TIGIT Inhibitor
1.1 Overview
1.2 Historical Perspective


2. Role of TIGIT Inhibitors in Cancer
2.1 Enhanced Anti-Tumor Effects
2.2 Reduced Immunosuppressive Functions
2.3 Augments Anti-Tumor Immunity


3. Role of TIGIT Inhibitors in HIV4. Role of TIGIT in Autoimmune Disorders5. Mechanism of TIGIT Inhibitor
6. Clinical Approaches to Target TIGIT
6.1 Therapeutic Monoclonal Antibodies
6.2 Bispecific Antibodies
6.3 Small Molecule Inhibitors


7. FDA Orphan Designation for Tiragolumab
8. Global TIGIT inhibitors Clinical Trials Overview
8.1 By Company
8.2 By Country
8.3 By Patient Segment


9. Global TIGIT inhibitors Clinical Trials Insight 2022
9.1 Research
9.2 Preclinical
9.3 Phase-I
9.4 Phase-I/II
9.5 Phase-II
9.6 Phase-III


10. Global TIGIT Inhibitor Market Dynamics
10.1 Market Drivers
10.2 Commercialization Challenges


11. Global TIGIT Inhibitor Market Future Outlook
12. Competitive Landscape
12.1 Acrus Biosciences
12.2 Agensus
12.3 Astellas Pharma
12.4 AstraZeneca
12.5 Beigene
12.6 Bristol Meyer Squibb
12.7 Compugen
12.8 Gilead Sciences
12.9 iTeos Therapeutics
12.10 Merck
12.11 Roche
12.12 Seagen
12.13 Seatle Genetics
12.14 Shanghai Helnius Biotech


List of Figures
Figure 1-1: TIGIT/DNAX Accessory Molecule-1 Pathway
Figure 2-1: Enhanced Anti-Tumor Effects of Dual TIGIT & PD-1 Blockade
Figure 2-2: Blockade of TIGIT on Tregs Reduces Their Immunosuppressive Functions
Figure 2-3: Blockade of TIGIT on NK Cells Augments Anti-Tumor Immunity
Figure 3-1: Hypothetical Outcomes of Using TIGIT Blockade for HIV-1 Therapy
Figure 4-1: TIGIT Associated Autoimmune Disorders
Figure 5-1: TIGIT Inhibitor - Proposed Mechanism of Action
Figure 5-2: TIGIT Inhibitor - Mechanism of Action
Figure 6-1: Binding Efficacy of Monoclonal Antibody
Figure 6-2: Binding Efficacy of Bispecific Antibodies
Figure 6-3: Advantages of Small Molecule Drugs over Therapeutic Antibodies
Figure 7-1: Tiragolumab - SKYSCRAPPER08 Phase-III Trial Initiation & Completion Year
Figure 8-1: Global - TIGIT Inhibitors Clinical Trials by Company, 2022
Figure 8-2: Global - TIGIT Inhibitors Clinical Trials by Country, 2022
Figure 8-3: Global - TIGIT Inhibitors Clinical Trials by Patient Segment, 2022
Figure 10-1: Global - Cancer Incidences & Deaths (Million), 2020 & 2025
Figure 10-2: Global - TIGIT Inhibitor Market Drivers
Figure 10-3: Stages of Drug Development

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Acrus Biosciences
  • Agensus
  • Astellas Pharma
  • AstraZeneca
  • Beigene
  • Bristol Meyer Squibb
  • Compugen
  • Gilead Sciences
  • iTeos Therapeutics
  • Merck
  • Roche
  • Seagen
  • Seatle Genetics
  • Shanghai Helnius Biotech