The global gene editing market was valued at $3,886.34 million in 2021, and is projected to reach $7,437.47 million by 2031, registering a CAGR of 6.7% from 2022 to 2031.
Gene editing (also known as genome editing) refers to a set of technologies that allows scientists to alter an organism's DNA. These technologies allow for the addition, removal, or modification of genetic material at specific points in the genome. There have been several ways to develop genome editing. CRISPR-Cas9, which stands for clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9, is one of the most well-known techniques. The CRISPR-Cas9 system has sparked a lot of interest in the scientific community as it is faster, cheaper, more accurate, and more efficient than existing genome editing approaches. CRISPR-Cas9 is based on a naturally occurring genome editing technology used by bacteria to defend themselves. When bacteria are infected with viruses, they capture small fragments of the virus's DNA and insert them into their own DNA in a specific way to form CRISPR arrays. Bacteria can 'remember' viruses, thanks to CRISPR arrays (or closely related ones). If the viruses resurface, the bacteria create RNA segments from CRISPR arrays that detect and attach to specific sections of the viruses' DNA. The bacteria then employ Cas9 or a similar enzyme to rip the virus's DNA apart, rendering it inoperable. This immune defense mechanism was modified to modify DNA by researchers. They make a small piece of RNA with a short 'guide' sequence that connects (binds) to a specific target sequence in a cell's DNA, similar to the RNA segments produced by bacteria using the CRISPR array. This guide RNA binds to the Cas9 enzyme as well. When the guide RNA is injected into cells, it detects the desired DNA sequence, and the Cas9 enzyme cuts the DNA at the desired position, similar to how bacteria do it. Although Cas9 is the most commonly employed enzyme, other enzymes (such as Cpf1) can also be used. Researchers employ the cell's own DNA repair mechanism to add or delete portions of genetic material, or to make modifications after the DNA has been cut.
Factors such as increased adoption of CRISPR genome editing technology along with expanding synthetic gene demand in various biotechnology areas have fueled the growth of the gene editing market. Furthermore, due to the growing uses of genome editing technologies, the industry is seeing increased competition among market competitors. The highly flexible CRISPR technique has gotten a lot of attention lately. For example, Vertex Pharmaceuticals paid CRISPR Therapeutics $900 million in April 2021 to develop, manufacture, and market CRISPR-Cas9 gene-edited treatment for beta-thalassemia and sickle-cell disease. Market growth is expected to be aided by such activities. Furthermore, the industry is being driven by the development of CRISPR-based innovative diagnostic tools to alleviate the negative effects of the COVID-19 pandemic.
The gene editing market is segmented on the basis of technology, application, end user, and region. On the basis of technology, the market is bifurcated into zinc finger nucleases, transcription activator-like effector-based, crispr-cas9 gene editing, restriction enzymes, and others. The others segment is further classified into homing endonucleases or meganucleases and antisense technology. By application, the market is segmented into gene editing, cell line engineering, animal genetic engineering, plant genetic engineering, drug development, and others. The others segment is further classified into bioenergy, diagnosis, cell and gene therapies, microorganisms genetic engineering, drug discovery, gmo (genetically modified organisms), vaccine development, and basic research. By end users, the market is fragmented into biotechnology & pharmaceutical companies, academic & government research institutes, and contract research organizations
Region-wise, the market is analyzed across North America, Europe, Asia-Pacific, and LAMEA.
Major key players that operate in the global gene editing market are Addgene, Allele Biotech, Bio-Rad Laboratories, CRISPR Therapeutics, General Electric, OriGene Technologies, Precision Biosciences, Takara Biotech, Thermo Fisher Scientific Inc., and Transposagen Biopharma Inc.
KEY BENEFITS FOR STAKEHOLDERS
- This report provides a quantitative analysis of the market segments, current trends, estimations, and dynamics of the gene editing market analysis from 2021 to 2031 to identify the prevailing gene editing market opportunities.
- Market research is offered along with information related to key drivers, restraints, and opportunities.
- Porter's five forces analysis highlights the potency of buyers and suppliers to enable stakeholders to make profit-oriented business decisions and strengthen their supplier-buyer network.
- In-depth analysis of the gene editing market segmentation assists to determine the prevailing market opportunities.
- Major countries in each region are mapped according to their revenue contribution to the global market.
- Market player positioning facilitates benchmarking and provides a clear understanding of the present position of the market players.
- The report includes an analysis of the regional as well as global gene editing market trends, key players, market segments, application areas, and market growth strategies.
Key Market Segments
By Technology
- Zinc Finger Nucleases (ZFNs)
- CRISPR-Cas9 Gene Editing
- Restriction Enzymes
- Others
- Transcription Activator-Like Effector-based Nucleases (TALENs)
By Application
- Drug development
- Others
- Gene editing
- Cell Line Engineering
- Animal Genetic Engineering
- Plant Genetic Engineering
By End User
- Biotechnology and Pharmaceutical Companies
- Academic and Government Research Institutes
- Contract Research Organizations
By Region
- North America
- U.S.
- Canada
- Mexico
- Europe
- Germany
- France
- U.K.
- Italy
- Spain
- Rest of Europe
- Asia-Pacific
- Japan
- China
- Australia
- India
- South Korea
- Rest of Asia-Pacific
- LAMEA
- Brazil
- Saudi Arabia
- South Africa
- Rest of LAMEA
Key Market Players
- Addgene
- Allele Biotech
- Bio-Rad
- Takara Bio
- CRISPR Therapeutics
- OriGene Technologies
- Precision Biosciences
- GE Healthcare
- Merck KGaA
- Thermo Fisher Scientific Inc.
Table of Contents
CHAPTER 1: INTRODUCTION
CHAPTER 2: EXECUTIVE SUMMARY
CHAPTER 3: MARKET OVERVIEW
CHAPTER 4: GENE EDITING MARKET, BY TECHNOLOGY
CHAPTER 5: GENE EDITING MARKET, BY APPLICATION
CHAPTER 6: GENE EDITING MARKET, BY END USER
CHAPTER 7: GENE EDITING MARKET, BY REGION
CHAPTER 8: COMPANY LANDSCAPE
CHAPTER 9: COMPANY PROFILES
List of Tables
List of Figures
Executive Summary
According to the report, titled, “Gene Editing Market," the gene editing market was valued at $3.9 billion in 2021, and is estimated to reach $7.4 billion by 2031, growing at a CAGR of 6.7% from 2022 to 2031.Gene editing also known as genome editing, is a field of study that aims to modify genes in live animals in order to better understand gene function and create treatments for hereditary and acquired disorders. In many different types of cells and species, genome editing can be used to fix, introduce, or delete practically any DNA sequence. While DNA editing techniques have been around for decades, new ways have made it faster, cheaper, and more efficient. The revelation that a broken portion of DNA in a gene stimulates a cell's repair system to patch the split together led to the development of genome editing. Researchers can use genome editing to replicate the natural process of DNA repair. Zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and meganucleases are advanced genome editing technologies based on proteins. Another approach is CRISPR/Cas9, which stands for clustered regularly interspaced short palindromic repeats.
In gene editing market trends CRISPR/Cas9 is the most extensively used genome editor, and it's a great way to figure out how genes work. Because CRISPR/Cas9 is an RNA-based system, it can be tweaked more quickly and easily than protein-based systems, and it can target many locations. CRISPR was discovered as a result of fundamental research financed by the National Institutes of Health into how bacteria defend themselves against viruses. CRISPR/Cas9 changes a single base pair of DNA, vast chunks of chromosomes, or gene expression regulation by cutting a DNA sequence at a specified genetic region and deleting or inserting DNA sequences these are the factors growing the market in gene editing market forecast period.
The major factors that drive the growth of global gene editing market are increased R&D expenditure and growth of the biotechnology and pharmaceutical industries, increase in private and public sector funding, rapid advancements in sequencing and Genome Editing technologies, non-labelling of gene-edited products such as Genetically Modified Organisms (GMOs), and applications in various drug discovery processes are some of the factors propelling personalized medicine forward. The promise for genome editing in the treatment of genetic abnormalities, infectious diseases, and cancer has been demonstrated in regions, including North America. Along with the benefits, there are growing worries about hazards and ethical difficulties of genome editing, which have an impact on the market. Off-target mutation development, environmental imbalance, and illicit genome editing are among the primary ethical concerns. The general public has an unfavorable attitude about gene editing. Several scientists have argued that genome editing should be banned or prohibited. This has put a lot of pressure on companies that work with genome editing, since they cannot locate eligible participants for clinical studies, which is slowing down innovation. As a result, it is posing a significant impediment to the expansion of the genomic testing business. Furthermore, the high cost of genomic equipment is a stumbling block for the genome editing market.
On the basis of technology, the gene editing market analysis is bifurcated into zinc finger nucleases, transcription activator-like effector-based nucleases, crispr-cas9 gene editing, restriction enzymes, and others. The others segment is further classified into homing endonucleases or mega nucleases and antisense technology. The crispr-cas9 gene editing segment dominated the market in 2021 with a revenue of $1,522.25 million and is expected to grow the gene editing industry with the highest CAGR of 7.9%. Growth of the segment is attributed to its application for drug discovery and identifying cancer market.
Depending on application, the gene editing market share is segmented into gene editing, cell line engineering, animal genetic engineering, plant genetic engineering, drug development, and others. The others segment is further classified into bioenergy, diagnosis, cell and gene therapies, microorganisms genetic engineering, drug discovery, GMO (genetically modified organisms), vaccine development, and basic research. The gene editing segment dominated the market in 2021 with a revenue of $1,123.16 million and is expected to grow with the highest CAGR of 8.2%. Growth of the segment is attributed to surge in clinical diagnosis and medical research.
By end user, the gene editing market size is fragmented into biotechnology & pharmaceutical companies, academic & government research institutes, and contract research organizations. The biotechnology and pharmaceutical companies segment dominated the market in 2021 with a revenue of $2,311.49 million. In gene editing market size, growth of the largest growing segment is attributed to increase in funding in R&D for drug development and cancer treatments. Academic and government institutes are expected to grow with the highest CAGR of 7.2% during the forecast period.
Region-wise, in gene editing industry, North America accounted for more than 6.6% of the global market share in 2021 with largest revenue of $1,723.2 million, during the forecast period. This was attributed to surge in cases of cancer and genetic disorders. Asia-Pacific is projected to register the highest CAGR of 7.7% during the forecast period, owing to surge in medical and clinical advancements.
Key Findings of the Study
- By technology, the crispr-cas9 gene editing segment held the largest share in the global market in 2021.
- On the basis of application, the gene editing segment held the largest market share in 2021 and is expected to remain dominant during the forecast period.
- By end user, the biotechnology and pharmaceutical companies segment held the largest market share in 2021.
- Region-wise, North America is expected to experience growth at the highest rate, registering a CAGR of 6.6% during the forecast period.
Companies Mentioned
- Addgene
- Allele Biotech
- Bio-Rad
- Takara Bio
- Crispr Therapeutics
- Origene Technologies
- Precision Biosciences
- Ge Healthcare
- Merck Kgaa
- Thermofischer Scientific Inc.
Methodology
The analyst offers exhaustive research and analysis based on a wide variety of factual inputs, which largely include interviews with industry participants, reliable statistics, and regional intelligence. The in-house industry experts play an instrumental role in designing analytic tools and models, tailored to the requirements of a particular industry segment. The primary research efforts include reaching out participants through mail, tele-conversations, referrals, professional networks, and face-to-face interactions.
They are also in professional corporate relations with various companies that allow them greater flexibility for reaching out to industry participants and commentators for interviews and discussions.
They also refer to a broad array of industry sources for their secondary research, which typically include; however, not limited to:
- Company SEC filings, annual reports, company websites, broker & financial reports, and investor presentations for competitive scenario and shape of the industry
- Scientific and technical writings for product information and related preemptions
- Regional government and statistical databases for macro analysis
- Authentic news articles and other related releases for market evaluation
- Internal and external proprietary databases, key market indicators, and relevant press releases for market estimates and forecast
Furthermore, the accuracy of the data will be analyzed and validated by conducting additional primaries with various industry experts and KOLs. They also provide robust post-sales support to clients.
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Table Information
| Report Attribute | Details |
|---|---|
| No. of Pages | 297 |
| Published | June 2022 |
| Forecast Period | 2021 - 2031 |
| Estimated Market Value ( USD | $ 3886.34 million |
| Forecasted Market Value ( USD | $ 7437.47 million |
| Compound Annual Growth Rate | 6.7% |
| Regions Covered | Global |
| No. of Companies Mentioned | 10 |
