In addition, the treatment landscape for bronchiectasis has evolved significantly in recent years, shifting from symptomatic treatments to more targeted, disease-modifying therapies. Macrolide antibiotics (e.g., azithromycin) are now routinely used to reduce exacerbations, prevent infections, and improve quality of life for patients.
Also, the development of biologics and immunomodulators represents the next frontier for treating bronchiectasis, especially in patients with autoimmune or inflammatory conditions. These therapies aim to target specific immune system pathways, reducing inflammation and preventing lung damage. There is growing interest in the role of biologics such as anti-TNF-alpha agents and interleukin inhibitors, which could significantly change the management of patients with chronic inflammation in bronchiectasis.
Despite the advances in treatment, challenges remain, such as high costs associated with biologic therapies and inhaled treatments, which can limit access, particularly in lower-income healthcare systems. Additionally, treatment adherence remains a significant issue, as bronchiectasis is a chronic condition requiring long-term management. Ensuring that patients stick to prescribed regimens, especially when involving complex inhalation therapies or daily antibiotics, remains a barrier to effective treatment.
The growing recognition of bronchiectasis as a distinct clinical condition is opening the door to more precision medicine approaches. This trend is driven by advancements in genetic profiling and biomarker discovery, which allow for targeted treatments tailored to specific patient profiles. Personalized therapies, particularly those aimed at cystic fibrosis-related bronchiectasis and autoimmune-driven bronchiectasis, are expected to gain traction in the market. Biologics and immunomodulators are among the most promising treatment options in personalized medicine, targeting specific pathways involved in airway inflammation and damage.
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Table of Contents
Companies Mentioned
- Insmed Incorporated
- AstraZeneca
- ZAMBON COMPANY S.P.A.
- Chiesi Farmaceutici S.p.A
- Armata Pharmaceuticals
- Merck
- Sanofi
- Boehringer Ingelheim International GmbH

