Bioinformatics for Glycobiology and Glycomics: An Introduction

  • ID: 1198557
  • Book
  • 494 Pages
  • John Wiley and Sons Ltd
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Glycobiology is the study of complex carbohydrates, or glycans, which play an important role in biochemical signalling between cells and hence in normal cell development. Deficiencies or excess production of particular glycans have been linked to human diseases and have also been shown to play a part in cancer development.

This book is the first to be dedicated to the bioinformatics of carbohydrates and glycoproteins.  It provides a state–of–the art overview and demonstrates the value of bioinformatics for glycobiology, not simply as a review of databases and tools but rather as an introduction to a new branch of glycobiology.

The availability of comprehensive databases and corresponding bioinformatics tools, to access and analyse the large amounts of data relating to the sequence and structure of carbohydrates, will be a prerequisite for the success of the large–scale glycomics projects that aim to decipher new, so far unknown, biological functions of glycans.

Interpretation of this sequence information will require new bioinformatics tools and the automated interpretation of experimental data, especially mass spectra, is currently the most active area of research.

Efficient bioinformatics descriptions and tools can considerably enhance the efficiency of glycomics research, in terms of data quality, analysis and experimental costs. This book illustrates how bioinformatics can be used to enhance glycomics data mining and improve glycomics analysis.

  • Clearly describes the bioinformatics tools that will allow analysis of carbohydrate structures.
  • Provides a comprehensive review of the area, giving both an introduction and an overview.
  • Assumes only a basic knowledge of biology and bioinformatics.
  • Illustrates the value of bioinformatics for glycomics data mining and analysis.
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List of Contributors.

Preface (Claus–Wilhelm von der Lieth).

Section 1: Introduction.

1. Glycobiology, Glycomics and (Bio)Informatics (Claus–Wilhelm von der Lieth).

Section 2: Carbohydrate Structures.

2. Introduction to Carbohydrate Structure and Diversity (Stephan Herget, René Ranzinger, Robin Thomson, Martin Frank and Claus–Wilhelm von der Lieth).

3. Digital Representations of Oligo– and Polysaccharides (Stephan Herget and Claus–Wilhelm von der Lieth).

4. Evolutionary Considerations in Studying the Sialome: Sialic Acids and the Host Pathogen Interface (Amanda L. Lewis and Ajit Varki).

Section 3: Carbohydrate–active Enzymes and Glycosylation.

5. Carbohydrate–active Enzymes Database: Principles and Classification of Glycosyltransferases (Pedro M. Coutinho, Corinne Rancurel, Mark Stam, Thomas Bernard, Francisco M. Couto, Etienne G. J. Danchin and Bernard Henrissat).

6. Other Databases Providing Glycoenzyme Data (Thomas L¨utteke and Claus–Wilhelm von der Lieth).

7. Bioinformatics Analysis of Glycan Structures from a Genomic Perspective (Kiyoko F. Aoki–Kinoshita and Minoru Kanehisa).

8. Glycosylation of Proteins (Claus–Wilhelm von der Lieth and Thomas Lüteke).

9. Prediction of Glycosylation Sites in Proteins (Karin Julenius, Morten B. Johansen, Yu Zhang, Søren Brunak and Ramneek Gupta).

Section 4: Experimental Methods Bioinformatic Requirements.

10. Experimental Methods for the Analysis of Glycans and Their Bioinformatics Requirements (Claus–Wilhelm von der Lieth).

11. Analysis of N– and O–Glycans of Glycoproteins by HPLC Technology (Anthony H. Merry and Sviatlana A. Astrautsova).

12. Glycomic Mass Spectrometric Analysis and Data Interpretation Tools (Niclas G. Karlsson and Nicolle H. Packer).

13. Software Tools for Semi–automatic Interpretation of Mass Spectra of Glycans (Kai Maass and Alessio Ceroni).

14. Informatics Concepts to Decode Structure–Function Relationships of Glycosaminoglycans (Rahul Raman, S. Raguram and Ram Sasisekharan).

15. NMR Databases and Tools for Automatic Interpretation of Spectra of Carbohydrates (Claus–Wilhelm von der Lieth).

16. Automatic Spectrum Interpretation Based on Increment Rules: CASPER (Roland Stenutz).

17. Interpretation of 13C NMR Spectra by Artificial Neural Network Techniques (NeuroCarb) (Andreas Stoeckli, Matthias Studer, Brian Cutting and Beat Ernst).

Section 5: 3D Structures of Complex Carbohydrates.

18. Conformational Analysis of Carbohydrates A Historical Overview (Martin Frank).

19. Predicting Carbohydrate 3D Structures Using Theoretical Methods (Martin Frank).

20. Synergy of Computational and Experimental Methods in Carbohydrate 3D Structure Determination and Validation (Thomas Lütteke and Martin Frank).

Section 6: Protein Carbohydrate Interaction.

21. Structural Features of Lectins and Their Binding Sites (Remy Loris).

22. Statistical Analysis of Protein Carbohydrate Complexes Contained in the PDB (Thomas Lütteke and Claus–Wilhelm von der Lieth).

Section 7: Appendices.

Appendix 1: List of Available Websites.

Appendix 2: Glossary.

Index.

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"This is an excellent and timely first comprehensive overview of the recent efforts directed toward organization and mining of data produced by the rapidly growing fields of glycobiology and glycomics." (The Quarterly Review of Biology, 1 March 2011)
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