The first part of the book contains an overview of sample preparation showing its relation to sample collection and to the core chromatographic analysis. The second part covers procedures that do not use chemical modifications of the analyte and includes methods for sample dissolution, concentration and cleanup designed mainly for modifying the initial matrix of the sample. This part starts with conventional separations such as filtration and distillation and finishes with more advanced techniques such as solid phase extraction and electroseparations. The third part gives a description of the chemical modifications that can be performed on a sample either for fractionation purposes or to improve a specific property of the analyte. This part includes derivatizations, polymer chemical degradations, and pyrolysis.
Sample Preparation Techniques using Physical Processes. Mechanical processing in sample preparation. Phase transfer separations applied in sample preparation. Headspace sampling techniques in gas chromatography. Solvent extraction. Sorbent extraction. Chromatographic procedures as preliminary separation. Membrane separations. Electroseparation techniques in sample preparation. Other separation techniques in sample preparation.
Sample Preparation Techniques involving Chemical Modifications. Chemical modifications for dissolution and fractionation. Purpose of derivatization in chromatographic analysis. Chemical reactions used in derivatization. Derivatization reactions for analytes with various functional groups. Chemical degradation of polymers and pyrolysis.