Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN).
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Table of Contents
1. The organization of the spinal cord2. Development of the spinal cord
3. The vertebral column and the spinal meninges
4. The spinal nerves
5. The spinal cord blood vessels
6. Cytoarchitecture of the spinal cord
7. Localization of motoneurons in the spinal cord
8. Spinal autonomic preganglionic neurons: the visceral efferent system of the spinal cord
9. Central nervous system control of micturition
10. Projections from the spinal cord to the brain
11. Projections from the brain to the spinal cord
12. The propriospinal system
13. Spinal cord transmitter substances
14. Spinal cord injury: experimental animal models and relation to human therapy
15. An atlas of the mouse spinal cord
16. An atlas of the rat spinal cord
17. Toward a spinal cord ontology