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Recent Advances in Parkinsons Disease, Vol 184. Progress in Brain Research

  • ID: 1770392
  • Book
  • October 2010
  • 368 Pages
  • Elsevier Science and Technology

This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.

  • Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications
  • Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research
  • All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

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Section I: Animal models of PD

- What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo

- Neurotoxic in vivo models of Parkinson's disease: recent advances
Timothy Greenamyre & Jason R. Cannon

- Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease
Stephen B. Dunnett & Mariah Lelos

- Genetic mouse models of Parkinson's disease: the state of the art
Marie-Francoise Chesselet & Iddo Magen

- Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease
Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik

- Modelling inflammatory pathogenesis of Parkinson's Disease
Malu Tansey & Christopher J. Barnum

- The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future
Susan Fox & Jonathan Brotchie

Section II: Exploring PD with brain imaging

- Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside
David Eidelberg & Chris C. Tang

- Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications
Jon Stoessl & Renju Kuriakose

- Brain imaging after neural transplantation
Paola Piccini & Marios Politis

- Imaging non-motor aspects of Parkinson's disease
David Brooks & Nicola Pavese

Section III: Frontiers in PD treatment

- Gene therapy for dopamine replacement
Deniz Kirik & Tomas Björklund, Erik Ahlm Cederfjäll

- Neurotrophic Factor Therapy for Parkinson's disease
Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay

- Neural grafting in Parkinson's disease: Problems and possibilities
Patrik Brundin, Roger A Barker and Malin Parmar

- Neural grafting in Parkinson´s disease: Unraveling the mechanisms underlying graft-induced dyskinesia
Emma L Lane, Anders Björklund, Stephen B Dunnett, Christian Winkler

- Deep Brain Stimulation: State of the Art and Novel Stimulation Targets
Andres Lozano & Francisco A. Ponce

- The challenge of Non-Motor Symptoms in Parkinson´s Disease
Ray Chaudhuri & Per Odin
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Bjorklund, Anders.
Cenci-Nilsson, Angela.

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