Inflammation and Allergy Drug Design

  • ID: 1936920
  • Book
  • 344 Pages
  • John Wiley and Sons Ltd
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Our knowledge and understanding of allergic diseases of the respiratory tract has improved to a point where new therapies are being developed for patient benefit.

Inflammation and Allergy Drug Design explains the biologic science that underpins the pathophysiology of asthma and related disorders, as well as their mechanisms. This authoritative guide consists of 25 chapters, each detailing the cutting–edge developments in a particular field. It is divided into three parts, covering cytokines, chemokines, grow factors and mediators.

This book allows immunologists, allergologists and researchers in the pharmaceutical industry to learn and appreciate the target biology in drug development. It also provides medical and pharmaceutical postgraduate
students and clinicians with a basic understanding of allergic diseases in the respiratory tract.

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Contributors, vii

Preface, xiii

Part I: Cells contributing to the pathogenesis of allergic diseases in the respiratory tract

1 Novel anti–infl ammatory drugs based on targeting lung dendritic cells and airway epithelial cells, 3Bart N. Lambrecht, Maud Plantinga, Monique Willart, and Hamida Hammad

2 Role of Th2 cells in the allergic diathesis, 15Marsha Wills–Karp

3 Importance of Th17– and Th1–associated responses for the development of asthma, 27Tomohiro Yoshimoto, Hiroko Tsutsui, and Kenji Nakanishi

4 Regulatory T cells, 39Chris Corrigan and Kimuli Ryanna

5 A role for natural killer T–cell subsets in the pathogenesis of various allergic disorders, 59Hiroshi Watarai, Michishige Harada, Mayumi Tamari, and Masaru Taniguchi

6 Regulatory roles of B cells in allergy and infl ammation, 67Kiyoshi Takatsu, Masashi Ikutani and Yoshinori Nagai

7 Mast cells, 79Mindy Tsai and Stephen J. Galli

8 Eosinophils, 107Nancy A. Lee, Mark V. Dahl, Elizabeth A. Jacobsen, and Sergei I. Ochkur

9 Basophils in infl ammation and allergy drug design, 123Donald MacGlashan, Jr.

10 Epithelial cells, 139Tillie–Louise Hackett, Stephanie Warner, Dorota Stefanowicz, and Darryl Knight

11 Fibroblasts, 149Alastair G. Stewart, Lilian Soon, and Michael Schuliga

12 Airway smooth muscle cells, 163Andrew J. Halayko and Pawan Sharma

Part II: Cytokines contributing to the pathogenesis of allergic diseases in the respiratory tract

13 Interleukin 4, interleukin 13, and interleukin 9, 175Kenji Izuhara, Shoichiro Ohta, Hiroshi Shiraishi, and Shoichi Suzuki

14 Interleukin 3, interleukin 5, and granulocyte macrophage colony–stimulating factor, 187Alba Llop–Guevara, Josip Marcinko, Ramzi Fattouh, and Manel Jordana

15 Interleukin 15, interleukin 17, and interleukin 25, 197Hiroshi Nakajima and Itsuo Iwamoto

16 Thymic stromal lymphopoietin, 205Kazuhiko Arima and Yong–Jun Liu

17 Interleukin 10, 215Whitney W. Stevens, Larry Borish, and John W. Steinke

18 Tumor necrosis factor alpha, 225Christopher Brightling, Latifa Chachi, Dhan Desai, and Yassine Amrani

19 Profi brotic and angiogenic factors in asthma, 237Neville Berkman and Francesca Levi–Schaffer

20 Chemokines, 253Luis M. Teran and Juan R. Velazquez

21 Epithelial growth factors, 263Yasuhiro Gon and Shu Hashimoto

Part III: Other mediators contributing to the pathogenesis of allergic diseases in the respiratory tract

22 Prostanoids, 273Sarah A. Maher, Deborah L. Clarke, and Maria G. Belvisi

23 Leukotrienes, 285Katsuhide Okunishi and Marc Peters–Golden

24 Proteases in allergy, 297Keisuke Oboki and Hirohisa Saito

25 Toll–like receptors, 307Jessica L. Allen, Aurelien Trompette, and Christopher L. Karp

Index, 317

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Edited by

K. Izuhara, MD, PhD, Saga Medical School, Nabeshima, Japan

Stephen T. Holgate, MD, DSc, FRCP, Southampton General Hospital, UK

Marsha Wills–Karp, PhD, Children s Hospital Medical Center, Cincinnati, USA
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