Written by a panel of academic experts, Viral Oncology is the first self–contained and comprehensive book to present both scientific and clinical information on viruses linked to some of the most important human cancers. Readers can turn to this book for the most in–depth and up–to–date coverage of: HPV–associated cancers; molecular events associated with HPV–induced human cancer; the role of the HPV E6 oncoprotein in malignant progression; virus association with brain tumors; involvement of the polyomavirus JCV in colorectal cancer; possibleassociation of BKV with prostate cancer; oncogenic transformation bypolyomavirus large T antigen; SV40 and human cancer; SV40 and mesothelioma; molecular immunology of hepatitis B associated viral cancer; hepatitis B vaccine and hepatocellular carcinoma; pathogenesis of acute and chronic hepatitis Cvirus infection; molecular mechanisms of hepatitis C virus–induced cellulartransformation; clinical aspects of HTLV–1 associated cancer; oncogenic potential of the HTLV–1 tax protein; HIV–associated malignancy; HIV–related lymphoma; biology and epidemiology of HHV–8; the role of KSHV in pathogenesis of Kaposi′ssarcoma; molecular pathobiology of EBV infection; and EBV as a pathogen.
Several chapters are devoted to the basic science of oncogenic viruses for thestudy of their pathogenesis, drug development, and employment of viral vectorsfor vaccine and gene therapy. The book also includes complementary clinically based chapters describing natural courses and treatments. Additionally, bonusclinical materials are embedded within chapters and an easy–to–use indexcompletes the book.
Viral Oncology is an essential resource for clinical and research oncologists in medical facilities and biological research laboratories; clinicians and scientists working in related biomedical areas; medical students working toward a first or higher degree in the life sciences and other biomedical fields; and pharmaceutical scientists and developers.
1 HUMAN PAPILLOMAVIRUS–ASSOCIATED CANCERS 1Rachel A. Katzenellenbogen and Denise A. Galloway
2 MOLECULAR EVENTS ASSOCIATED WITH HUMAN PAPILLOMAVIRUS–INDUCED HUMAN CANCERS 23Amy Baldwin and Karl Münger
3 THE ROLE OF THE HUMAN PAPILLOMAVIRUS E6 ONCOPROTEIN IN MALIGNANT PROGRESSION 57Miranda Thomas, David Pim, and Lawrence Banks
4 JC VIRUS ASSOCIATION WITH BRAIN TUMORS: THE ROLE OF T ANTIGEN AND INSULIN–LIKE GROWTH FACTOR 1 IN DNA REPAIR FIDELITY 89Krzysztof Reiss, Kamel Khalili, and Luis Del Valle
5 INVOLVEMENT OF THE POLYOMAVIRUS, JC VIRUS, IN COLORECTAL CANCER 113C. Richard Boland, Luigi Ricciardiello, and Ajay Goel
6 POSSIBLE ASSOCIATION OF BK VIRUS WITH PROSTATE CANCER 129Michael J. Imperiale and Dweepanita Das
7 ONCOGENIC TRANSFORMATION BY POLYOMAVIRUS LARGE T ANTIGEN 149Abhilasha V. Rathi and James M. Pipas
8 SIMIAN VIRUS 40, HUMAN INFECTIONS, AND CANCER: EMERGING CONCEPTS AND CAUSALITY CONSIDERATIONS 165Janet S. Butel
9 SIMIAN VIRUS 40 AND MESOTHELIOMA 191Natalya Baranova and Michele Carbone
10 MOLECULAR IMMUNOBIOLOGY OF HEPATITIS B–ASSOCIATED VIRAL CANCER 211Timothy M. Block and Anand S. Mehta
11 HEPATITIS B VACCINE AND HEPATOCELLULAR CARCINOMA 225Mei–Hwei Chang and Ding–Shinn Chen
12 PATHOGENESIS OF ACUTE AND CHRONIC HEPATITIS C VIRUS INFECTION 243Mark A. Feitelson, Helena M.G.P.V. Reis, Jingbo Pan, and Bill Sun
13 MOLECULAR MECHANISMS OF HEPATITIS C VIRUS–INDUCED CELLULAR TRANSFORMATION 267Donna Sir and Jing–Hsiung James Ou
14 CLINICAL ASPECTS OF HTLV–1–ASSOCIATED CANCER 279Masao Matsuoka
15 ONCOGENIC POTENTIAL OF THE HTLV–1 TAX PROTEIN 295Susan J. Marriott
16 HIV–1–ASSOCIATED MALIGNANCY: BASIC AND CLINICAL ASPECTS 317Melissa Agsalda and Bruce Shiramizu
17 HIV–RELATED LYMPHOMA 337Giulia De Falco, Cristiana Bellan, Stefano Lazzi, and Lorenzo Leoncini
18 BIOLOGY AND EPIDEMIOLOGY OF HHV–8 351Veenu Minhas and Charles Wood
19 THE ROLE OF KSHV IN PATHOGENESIS OF KAPOSI S SARCOMA 377Gary S. Hayward, Donald J. Alcendor, and Ravit Arav–Boger
20 MOLECULAR PATHOBIOLOGY OF EBV INFECTION 409Joseph S. Pagano
21 EPSTEIN BARR VIRUS AS A PATHOGEN 425Wasim A. Dar and Bill Sugden