Endometriosis. Science and Practice

  • ID: 2222825
  • Book
  • 600 Pages
  • John Wiley and Sons Ltd
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Science merged with clinical practice towards relieving the symptoms of endometriosis

Endometriosis is frequently intensely painful and can lead to infertility causing disruption of women′s lives and relationships. It can be a devastating condition. Major progress has been made in recent years on understanding the causes of endometriosis and developing effective clinical therapies.

Endometriosis: Science and Practice fuses the scientific and clinical approaches. It marries the characteristics of the disease, how it presents and possible causes with medical and surgical approaches to pain therapy, and wider aspects of the disease.

Broad in outlook, focused in application, Endometriosis: Science and Practice covers:

  • Pathogenesis
  • Disease Characterization
  • Biological basis of Endometriosis
  • Diagnosis
  • Medical Therapies
  • Surgical Therapies
  • Infertility
  • Associated Disorders

The stellar cast of contributors, led by world–leading editors from the US, Europe and Asia–Pacific, have produced a contemporary tour–de–force that should be on the bookshelf of anyone who provides medical care for women.

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List of Contributors, viii

Preface, xiii

List of Abbreviations, xv

Part 1: History, Epidemiology, and Economics

1 History of Endometriosis: A 20th–Century Disease, 3Ivo Brosens and Giuseppe Benagiano

2 Endometriosis: Epidemiology, and Etiological Factors, 19Fabio Parazzini, Paolo Vercellini and Claudio Pelucchi

3 Economic Perspective on Diagnosis and Treatment of Endometriosis, 27Steven Simoens and Thomas M. D Hooghe

Part 2: Pathogenesis

4 Pathogenesis: Development of the Female Genital Tract, 35Jolande A. Land and Johannes L.H. Evers

5 Theories on the Pathogenesis of Endometriosis, 42Annemiek W. Nap

6 Understanding the Pathogenesis of Endometriosis: Gene Mapping Studies, 54Jodie N. Painter, Krina T. Zondervan and Grant W. Montgomery

7 Pathogenesis: Epigenetics, 65Sun–Wei Guo

Part 3: Disease Characterization

8 Endometriosis: Disease Classification and Behavior, 81G. David Adamson

9 Peritoneal, Ovarian, and Rectovaginal Endometriosis are Three Different Entities, 92Jacques Donnez, Olivier Donnez, Jean–Christophe Lousse and Jean Squifflet

10 Extra–abdominal Endometriosis, 108Antonio Bobbio, Diane Damotte, Anne Gompel and Marco Alifano

Part 4: Biological Basis and Pathophysiology of Endometriosis

11 Biology of Eutopic and Ectopic Endometrium in Women with Endometriosis, 117Petra A. B. Klemmt and Anna Starzinski–Powitz

12 Stem Cells in Endometriosis, 130Caroline E. Gargett, Hirotaka Masuda and Gareth C. Weston

13 Role of Steroid Hormones: Estrogen and Endometriosis, 140Elke Winterhager

14 Role of Steroid Hormones: Progesterone Signaling, 145Shirin Khanjani, Marwa K. Al–Sabbagh, Luca Fusi and Jan J. Brosens

15 Early Origins of Endometriosis: Role of Endocrine Disrupting Chemicals, 153Germaine M. Buck Louis

16 Signaling Pathways in Endometriosis (Eutopic/Ectopic), 164J. Julie Kim and Xunqin Yin

17 MicroRNAs in Endometriosis, 173M. Louise Hull and Cristin G. Print

18 HOX Genes and Endometriosis, 184Jennifer L. Kulp, Hakan Cakmak and Hugh S. Taylor

19 Angiogenesis and Endometriosis, 190Patrick. G. Groothuis

20 Uterine Peristalsis and the Development of Endometriosis and Adenomyosis, 200Gerhard Leyendecker and Ludwig Wildt

21 Pelvic Mechanisms Involved in the Pathophysiology of Pain in Endometriosis, 212Ian S. Fraser, Natsuko Tokushige, Alison J. Hey–Cunningham, Marina Berbic and Cecilia H. M. Ng

22 Neuroendocrine Aspects of Endometriosis–Associated Pain, 230Pamela Stratton and Karen J. Berkley

23 Pathophysiology of Infertility in Endometriosis, 240Bruce A. Lessey and Steven L. Young

24 Inflammation and Endometriosis, 255Daniela Hornung and Ursula von Wussow

Part 5: Models of Endometriosis

25 Models of Endometriosis: In vitro and In vivo Models, 265Ruth Grümmer

26 Models of Endometriosis: Animal Models I Rodent–based Chimeric Models, 270Kaylon L. Bruner–Tran, Melinda E. McConaha and Kevin G. Osteen

27 Models of Endometriosis: Animal Models II Non–human Primates, 285Asgerally T. Fazleabas

Part 6: Diagnosis of Endometriosis

28 Surgical Historical Overview, 295Ayman Al–Talib and Togas Tulandi

29 Diagnosis of Endometriosis: Imaging, 299Gerard A. J. Dunselman and Regina G. H. Beets–Tan

30 Diagnosis of Endometriosis: Biomarkers, 309Beata E. Seeber and Kurt T. Barnhart

31 Diagnosis of Endometriosis: Proteomics, 324Andrew N. Stephens, Luk J. F. Rombauts and Lois A. Salamonsen

32 Diagnosis of Endometriosis: Transcriptomics, 336Richard O. Burney and Linda C. Giudice

Part 7: Medical Therapies for Pain

33 Medical Therapies: Randomized Controlled Trials/Traditional Medical Therapies, 343Neil P. Johnson

34 Medical Therapies: Progestins, 351Andrew Horne and Hilary O. D. Critchley

35 Medical Therapies: Aromatase Inhibitors, 357Serdar E. Bulun, Erkut Attar, Bilgin Gurates, You–Hong Chen, Hideki Tokunaga, Diana Monsivais and Mary Ellen Pavone

36 Medical Therapies: Statins, 366Anna Sokalska and Antoni J. Duleba

Part 8: Surgical Therapies for Pain

37 Surgical Therapies: Principles and Triage in Endometriosis, 387Alan Lam, Tommaso Bignardi and Su–Yen Khong

38 Surgical Therapies: Peritoneal Endometriosis Surgery, 396Michael P. Diamond and Valerie I. Shavell

39 Surgical Therapies: Pouch of Douglas and Uterovaginal Pouch Resection for Endometriosis, 402Maurício S. Abrão, Sérgio Podgaec and Luiz Flávio Cordeiro Fernandes

40 Surgical Therapies: Randomized Controlled Trials in Endometriosis, 410Jason Abbott

41 Surgical Therapies: Rectal/Bowel Endometriosis, 419Jim Tsaltas

42 Surgical Therapies: Ureteric Dissection and Urological Endometriosis, 426Anna Rosamilia and Caroline Dowling

43 Surgical Therapies: Robotics and Endometriosis, 438Camran Nezhat, Arathi Veeraswamy and Chandhana Paka

Part 9: Infertility and Endometriosis

44 Medical Therapy of Endometriosis: Subfertility, 449Johannes L. H. Evers

45 Infertility Therapies: The Role of Surgery, 455Oswald Petrucco and David L. Healy

46 Infertility Therapies: The Role of Assisted Reproductive Technologies, 462Kimberly Moon, Jeris Cox and Alan DeCherney

47 Ovarian Endometrioma: Surgery and Fertility Preservation, 473Luk J. F. Rombauts

Part 10: Associated Disorders

48 Endometriosis and Autoimmunity, 485Srinu Pathivada and Thomas D Hooghe

49 Endometriosis and Cancer: Epidemiology, 501Paola Viganò, Edgardo Somigliana, Fabio Parazzini and Paolo Vercellini

50 Molecular Mechanisms Underlying Endometriosis and Endometriosis–Related Cancers, 512Daniela Dinulescu

51 Pregnancy and Obstetric Outcomes in Women with Endometriosis, 519Henrik Falconer

52 Sexuality in Endometriosis, 524Brigitte Leeners

53 Psychosomatic Aspects, 533Brigitte Leeners

54 Endometriosis in the Adolescent Patient, 548Claire Templeman

55 Fertility Preservation in Patients with Endometrioma, 555Jennifer Hirshfeld–Cytron, Candace Tingen and Teresa K. Woodruff

56 Eye to the Future: Research, Diagnostics, and Therapeutics, 560Peter A.W. Rogers and Gareth C. Weston

Index, 565

The color plate section can be found facing p. 78

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The stellar cast of contributors, led by world–leading editors from the US, Europe, and Asia–Pacific, have produced a contemporary tour–de–force that should be on the bookshelf of anyone who provides medical care for women.   (The Journal of Obstetrics and Gynecology of India, 1 May 2014)

This book is an excellent resource for trainees who want to further their knowledge of endometriosis as well as senior doctors who want to keep up–to–date with recent advances in diagnosis and management of endometriosis.   (The Obstetrician & Gynaecologist, 1 October 2013)

It provides a comprehensive approach to the biology, diagnosis, and treatment of endometriosis, showcasing the latest in molecular, genetic, and epigenetic research underlying the pathophysiology of endometriosis.  It is a must read for every single person who is serious about moving the field of endometriosis forward.   (Endometriosis.org, 2012)

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