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Acute Myeloid Leukemia (AML) Therapeutics - Global Market Trajectory & Analytics

  • ID: 2227999
  • Report
  • April 2022
  • Region: Global
  • 356 Pages
  • Global Industry Analysts, Inc

FEATURED COMPANIES

  • AbbVie Inc.
  • Amgen Inc.
  • Astellas Pharma Inc.
  • CTI BioPharma Corp.
  • F. Hoffmann-La Roche AG
  • Janssen-Cilag Limited

Global Acute Myeloid Leukemia (AML) Therapeutics Market to Reach $976.2 Million by 2026


Leukemias are malignant disorders, the main symptom of which is an abnormally high leucocyte count in the human bone marrow and/or blood. The disease causes a substantial number of deaths worldwide every year. The types of Leukaemia vary by origin, pathogenesis, prognosis, and incidence. The dominant leukemia cells may be mature cells like in chronic lymphocytic leukemia (CLL); acute leukemias with precursor cells of multiple lineages; or both mature and precursor cells like in chronic myeloid leukemia (CML). Among the severe types of leukemia, acute lymphoblastic leukemia (ALL) is often seen in children as also in young adults, particularly in the 2 to 5 years age groups, whereas acute myeloid leukemia (AML) is more commonly seen in adults. Additionally, other rare leukemia types like atypical chronic myeloid leukemia differ from the four major types in numerous respects.

Leukaemia incidences vary among patients of different sexes, ages and races and these disparities are associated primarily with levels of environmental exposure as also genetic factors. For instance, nearly 10% of patients developing CLL have a history of the ailment in the family. Similarly, ionizing radiation has been identified as a definite cause for ALL in children, and usually happens by way of X-ray pelvimetry done during a pregnancy. Due to previous initiatives taken for combating leukemia, the disease's epidemiology can change with time, varying from nation to nation. Hence, being aware of leukemia's upgraded epidemiological data and analyzing the ailment's temporal trends are vital to learn about its burden and also to assess the overall effectiveness of prevention strategies adopted previously.

Amid the COVID-19 crisis, the global market for Acute Myeloid Leukemia (AML) Therapeutics estimated at US$587.6 Million in the year 2022, is projected to reach a revised size of US$976.2 Million by 2026, growing at a CAGR of 12.6% over the analysis period. Cytarabine, one of the segments analyzed in the report, is projected to grow at a 15.1% CAGR to reach US$366.4 Million by the end of the analysis period. After a thorough analysis of the business implications of the pandemic and its induced economic crisis, growth in the Anthracycline Drugs segment is readjusted to a revised 13.9% CAGR for the next 7-year period. This segment currently accounts for a 18.2% share of the global Acute Myeloid Leukemia (AML) Therapeutics market.



The U.S. Market is Estimated at $217.3 Million in 2022, While China is Forecast to Reach $85.7 Million by 2026


The Acute Myeloid Leukemia (AML) Therapeutics market in the U.S. is estimated at US$217.3 Million in the year 2022. The country currently accounts for a 37.19% share in the global market. China, the world's second largest economy, is forecast to reach an estimated market size of US$85.7 Million in the year 2026 trailing a CAGR of 14.9% through the analysis period. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 11% and 11.5% respectively over the analysis period. Within Europe, Germany is forecast to grow at approximately 12.1% CAGR while Rest of European market (as defined in the study) will reach US$97 Million by the close of the analysis period.

The market is set to experience a lucrative growth over the coming years on account of confluence of various factors like rising prevalence of the medical condition and its relapse cases along with increasing focus on development of novel therapies. Increasing cases of acute myeloid leukemia can be credited to several factors like unhealthy lifestyles, genetic mutations, radiation exposure and extended exposure to certain toxic chemicals like benzene. There were around 61,780 new cases of leukemia and 22,840 mortalities in 2019 in the US. The number of acute myeloid leukemia cases was estimated at 21,450, with adults accounting for a major fraction of the patient population. The increasing prevalence along with high mortality rate in the US and other countries is paving way for higher uptake of associated therapies. The market growth is also favored by rising aging population and unmet healthcare needs. Moreover, the market expansion is favored by various benefits of biopharmaceuticals over traditional drugs, an impressive biopharmaceutical pipeline and continuing development of several combination therapies capable of treating challenging medical conditions.

The market is also slated to gain from ongoing advancements in molecular biology and pharmacology for development of novel drugs. Pharmaceutical players operating on the market are making significant investments in research projects to come up with novel options. These R&D endeavors are also attributed to limitations associated with existing therapies available on the market for acute myeloid leukemia. Traditional options for the medical condition are unable to control relapse and linked with various side-effects such as tissue damage, nausea and loss of appetite. These issues are driving companies to focus on advanced approaches such as serine-threonine protein kinases, stem cell transplant and pipeline drugs. The market growth is bound to be facilitated by upcoming therapies such as farnesyltransferase inhibitors, alkylating agents, immunotoxins, FMS-like tyrosine kinase 3 inhibitors, monoclonal antibodies and multi-drug-resistant modulators. These therapies are anticipated to gain acceptance owing to their enhanced survival rates, quality and safety.

Tyrosine Kinase Inhibitors Segment to Reach $114.9 Million by 2026


The market growth is bound to be facilitated by upcoming therapies such as FMS-like tyrosine kinase 3 inhibitors. These therapies are anticipated to gain acceptance owing to their enhanced survival rates, quality and safety. In the global Tyrosine Kinase Inhibitors segment, USA, Canada, Japan, China and Europe will drive the 10.1% CAGR estimated for this segment. These regional markets accounting for a combined market size of US$52.6 Million will reach a projected size of US$103.2 Million by the close of the analysis period. China will remain among the fastest growing in this cluster of regional markets. Led by countries such as Australia, India, and South Korea, the market in Asia-Pacific is forecast to reach US$8.9 Million by the year 2026.

Select Competitors (Total 112 Featured) -

  • AbbVie Inc.
  • Actinium Pharmaceuticals, Inc.
  • Agios Pharmaceuticals, Inc.
  • Amgen Inc.
  • Astellas Pharma Inc.
  • Astex Pharmaceuticals, Inc.
  • CTI BioPharma Corp.
  • Cyclacel Pharmaceuticals, Inc.
  • Daiichi Sankyo Company Limited
  • F. Hoffmann-La Roche AG
  • Janssen-Cilag Limited
  • Jazz Pharmaceuticals plc
  • MEI Pharma, Inc.
  • Merus N.V.
  • Novartis AG
  • Pfizer Inc.
  • Takeda Pharmaceutical Company Limited

What's New for 2022?

  • Global competitiveness and key competitor percentage market shares
  • Market presence across multiple geographies - Strong/Active/Niche/Trivial
  • Online interactive peer-to-peer collaborative bespoke updates
  • Access to the publisher's digital archives and Research Platform
  • Complimentary updates for one year
Frequently Asked Questions about the Global Market for Acute Myeloid Leukemia (AML) Therapeutics

What is the estimated value of the Global Market for Acute Myeloid Leukemia (AML) Therapeutics?

The Global Market for Acute Myeloid Leukemia (AML) Therapeutics was estimated to be valued at $587.6 Million in 2022.

What is the growth rate of the Global Market for Acute Myeloid Leukemia (AML) Therapeutics?

The growth rate of the Global Market for Acute Myeloid Leukemia (AML) Therapeutics is 13.5%, with an estimated value of $976.2 Million by 2026.

What is the forecasted size of the Global Market for Acute Myeloid Leukemia (AML) Therapeutics?

The Global Market for Acute Myeloid Leukemia (AML) Therapeutics is estimated to be worth $976.2 Million by 2026.

Who are the key companies in the Global Market for Acute Myeloid Leukemia (AML) Therapeutics?

Key companies in the Global Market for Acute Myeloid Leukemia (AML) Therapeutics include AbbVie Inc., Actinium Pharmaceuticals, Inc., Agios Pharmaceuticals, Inc., Amgen Inc., Astellas Pharma Inc., Astex Pharmaceuticals, Inc., CTI BioPharma Corp., Cyclacel Pharmaceuticals, Inc. and F. Hoffmann.
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • AbbVie Inc.
  • Amgen Inc.
  • Astellas Pharma Inc.
  • CTI BioPharma Corp.
  • F. Hoffmann-La Roche AG
  • Janssen-Cilag Limited

I. METHODOLOGY


II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW

  • COVID-19 IMPACT AND THE LOOMING RECESSION
  • COVID-19’s Impact on Cancer Patients
  • Making the Cancer Patient Survive the Lethal Covid-19 Wave
  • Post-Covid-19 Complications to Affect Future Cancer Treatment
  • The Evolving Model of Care - Virtual/ Telemedicine Consultations
  • The Evolving Model of Care - Extending Care through Innovative Means
  • Pandemic Causes Delays in Procedures and Treatment
  • In-Office Cancer Patient Visits Decline amidst Pandemic
  • Vaccine Availability Comforts Cancer Patients
  • COVID-19 IMPACT ON ACUTE MYELOID LEUKEMIA THERAPEUTICS
  • Pandemic Caused Delays Impact AML Patients
  • Pandemic Related Issues Affect Oncology Research
  • Competition
  • EXHIBIT 1: Acute Myeloid Leukemia (AML) Therapeutics - Global Key Competitors Percentage Market Share in 2021 (E)
  • Competitive Market Presence - Strong/Active/Niche/Trivial for Players Worldwide in 2022 (E)
  • LEUKEMIA - A DISEASE OF THE BONE MARROW
  • A Prelude to Acute Myeloid Leukemia (AML)
  • Acute Myeloid Leukemia: Epidemiology
  • Acute Myeloid Leukemia (AML) Types
  • The FAB Classification of AML
  • WHO AML Classification
  • Etiology of AML
  • AML Symptoms
  • GLOBAL MARKET OUTLOOK AND PROSPECTS
  • Acute Myeloid Leukemia (AML) Therapeutics Market Primed for Massive Growth with Rising Patient Count & Promising Research Efforts
  • Drug Development Efforts Set Pace for Global Market
  • New Therapies Introduced in the Landscape
  • RECENT LAUNCHES IN THE AML MARKET
  • North America Maintains Leadership Position in Global Market
  • Chemotherapy: The Standard Mode of Treatment for AML Over the Years
  • Emerging Drug Therapies/Targeted Therapies for Acute Myeloid Leukemia to Drive the Market
  • FLT3 Inhibitors & Cytarabine: Bright Segments of Acute Myeloid Leukemia Therapeutics Market
  • EXHIBIT 2: Global FLT3 Inhibitors Market: Annual Sales in US$ Million for Years 2020 through 2027
  • EXISTING & POTENTIAL TREATMENT/THERAPEUTIC TARGETS FOR ACUTE MYELOID LEUKEMIA
  • Chemotherapy
  • AML Treatment
  • Stem Cell Transplant for Acute Myeloid Leukemia (AML)
  • Targeted Therapies Drive the Future of AML Market
  • ISOCITRATE DEHYDROGENASES (IDH)
  • BCL-2 Inhibitor
  • FLT3
  • Hedgehog (Hh)
  • Immunotherapy-Oriented Treatments
  • Neurotransmitter Receptors
  • Epigenetic Modulators
  • Organelle-Directed Strategies
  • New Formulations Using Existing Options
  • Antibody-Drug Conjugate Therapy for Acute Leukemia
  • Competitive Environment of AML Market
  • EXHIBIT 3: Targeted Therapies Market for AML by Product Class: Market Size Estimates in USD Million for 2020
  • EXHIBIT 4: Targeted Therapies Market for AML (2020) by Leading Drugs: Market Share of Revenues
  • RECENT MARKET ACTIVITY

2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS

  • High Incidence and Prevalence Drive Market Growth
  • Ballooning Elderly Population: The Vital Growth Driver for AML Therapeutics
  • EXHIBIT 5: Expanding Elderly Population Worldwide: Breakdown of Number of People Aged 65+ Years in Million by Geographic Region for the Years 2019 and 2030
  • EXHIBIT 6: Life Expectancy for Select Countries in Number of Years: 2019
  • Advancements in Pharmacology & Molecular Biology to Promote AML Drug Development
  • Recent Drug Approvals
  • Rising Investments in AML Therapeutics R&D Augurs Well
  • Changing Face of Combination Therapies Improve Outcomes for treated Secondary AML
  • University of Texas’ Combination Therapy Study Shines Light at the end of Tunnel for Acute Myeloid Leukemia
  • Need for Better Treatments Entrenches Proteomics at Center of Acute Myeloid Leukemia Therapeutics R&D
  • Antibody-Oriented Protein Microarrays
  • AML - A Medical Challenge with High Relapse Rate
  • Therapeutic Landscape for Refractory/Relapsed Acute Myeloid Leukemia
  • Advances Related to FLT3 Inhibitors
  • Gilteritinib to Set New Therapeutic Paradigm for Acute Myeloid Leukemia
  • Novel Combination Therapies for Relapsed or Refractory AML
  • Novel Therapies for Treatment of Pediatric Relapsed AML
  • Immunotherapy Research for AML
  • Monoclonal Antibody (Mylotarg) - A Promising Drug
  • Chemotherapy Complications to Hinder the AML Market Growth

4. GLOBAL MARKET PERSPECTIVE


III. MARKET ANALYSIS

UNITED STATES

  • Acute Myeloid Leukemia (AML) Therapeutics Market Presence - Strong/Active/Niche/ Trivial - Key Competitors in the United States for 2022 (E)
  • Market Analytics

CANADA


JAPAN


CHINA

EUROPE

  • Acute Myeloid Leukemia (AML) Therapeutics Market Presence - Strong/Active/Niche/ Trivial - Key Competitors in Europe for 2022 (E)
  • Market Analytics

FRANCE


GERMANY


ITALY


UNITED KINGDOM


SPAIN


RUSSIA


REST OF EUROPE


ASIA-PACIFIC


AUSTRALIA


INDIA


SOUTH KOREA


REST OF ASIA-PACIFIC


LATIN AMERICA


MIDDLE EAST


AFRICA

IV. COMPETITION

  • Total Companies Profiled: 112
Note: Product cover images may vary from those shown

A selection of companies mentioned in this report includes:

  • AbbVie Inc.
  • Actinium Pharmaceuticals, Inc.
  • Agios Pharmaceuticals, Inc.
  • Amgen Inc.
  • Astellas Pharma Inc.
  • Astex Pharmaceuticals, Inc.
  • CTI BioPharma Corp.
  • Cyclacel Pharmaceuticals, Inc.
  • Daiichi Sankyo Company Limited
  • F. Hoffmann-La Roche AG
  • Janssen-Cilag Limited
  • Jazz Pharmaceuticals plc
  • MEI Pharma, Inc.
  • Merus N.V.
  • Novartis AG
  • Pfizer Inc.
  • Takeda Pharmaceutical Company Limited
Note: Product cover images may vary from those shown