The definitive benchmark for musculoskeletal dealmaking
Musculoskeletal partnering spans a range of degenerative, inflammatory, and injury-related conditions, with deal structures reflecting diverse treatment approaches across pharmaceuticals, biologics, and orthopedic interventions.This report provides a comprehensive and structured analysis of 509 musculoskeletal collaboration and licensing deals, delivering a clear and evidence-based view of how partnerships are designed, negotiated, and executed across the market.
Establish a clear view of market standards
The report enables a precise understanding of how musculoskeletal deals are structured in practice, allowing you to:
- Benchmark comparable transactions with confidence
- Detailed analysis of upfronts, milestones, and royalty structures across relevant deals
- Define realistic market parameters
- Clear insight into how deal terms vary by stage, asset type, and partner profile
- Support valuation and structuring decisions with evidence
- Ground internal discussions in real transaction data rather than assumptions
- Understand how leading companies approach dealmaking
- Visibility into partner behaviour and recurring deal structures across a clinically diverse and treatment-focused landscape
- Full visibility into deal structure and execution
This includes:
- Rights granted and retained
- Development and commercialization responsibilities
- Financial structures and payment triggers
- Key contractual provisions and protections
Designed for real-world BD and strategy use
The report is widely used to:
- Structure and benchmark live transactions
- Prepare for negotiations with well-defined market context
- Evaluate partnership opportunities and counterparties
- Support internal strategy with robust, defensible data
What’s included?
- 509 musculoskeletal collaboration and licensing deals
- Financial terms, including upfronts, milestones, and royalties where disclosed
- Fully searchable deal directory (by company, therapy, and technology)
- Direct access to SEC-filed agreements and source documents
- Analysis of deal trends, key transactions, and active dealmakers
- A trusted, evidence-based reference for musculoskeletal dealmaking
Table of Contents
Executive SummaryChapter 1 - Introduction
Chapter 2 - Trends in musculoskeletal dealmaking
Chapter 3 - Financial deal terms for musculoskeletal partnering
Chapter 4 - Leading musculoskeletal deals and dealmakers
Chapter 5 - Musculoskeletal contract document directory
Chapter 6 - Musculoskeletal dealmaking by therapeutic target
Deal directory
List of Figures
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- 3D-Side
- 3DR Labs
- 3SBio
- 4P-Pharma
- 4P Therapeutics
- 10X Genomics
- Abbvie
- AbCellera Biologics
- AbTherx
- AC Bioscience
- Accenture
- Aclarion
- Adaptive Biotechnologies
- Advanced Development of Additive Manufacturing
- AdventHealth
- Affinia Therapeutics
- AGC Asahi Glass
- Ageless Biotech
- AgNovos Healthcare
- Akashi Therapeutics
- AKL Research and Development
- Alcyone Therapeutics
- Alexion Pharmaceuticals
- Alfasigma
- Aligos Therapeutics
- Alkem Laboratories
- Allay Therapeutics
- Allegro
- Almirall
- Alpine Immune Sciences
- Altasciences
- Alvogen
- Alvotech
- Ambry Genetics
- Amend Surgical
- American Association of Neuromuscular & Electrodiagnostic Medicine
- American Regent
- Amgen
- Amneal Pharmaceuticals
- AMRA
- AMRA Medical
- Anagenesis Biotechnologies
- AnaMar
- Andelyn Biosciences
- Angers University
- Anika Therapeutics
- AnnJi Pharmaceutical
- Antibe Therapeutics
- Apple
- Apsen Farmacutica
- Aptahem
- Aptorum Group
- Aratana Therapeutics
- Aravive Biologics
- Argenta
- argenx
- ARK Crystal
- Armatus Bio
- Arrowhead Pharmaceuticals
- Arthrosi Therapeutics
- Artialis
- Asahi Kasei
- AskAt
- Asklepios Biopharmaceutical
- Astellas Pharma
- AstraZeneca
- ATEC Spine
- Attwill Medical Solutions
- Audentes Therapeutics
- Augurex Life Sciences
- Aurinia Pharmaceuticals
- Autotelic BIO
- Avalere Health
- Avenue Therapeutics
- Aveta Biomics
- AveXis
- Avidity Biosciences
- Avion Pharmaceuticals
- Axelys
- Axovant Gene Therapies
- Back-A-Line
- Baebies
- Bayer
- Baylor College of Medicine
- BC Platforms
- Beijing Tide Pharmaceutical
- Benitec Biopharma
- Berg
- BGI
- Biedermann Motech
- BinnoPharm
- Bio-Thera Solutions
- BioCanRx
- Biogen
- BioGen Medical
- Biohaven Pharmaceuticals
- BioMarin Pharmaceutical
- BioMed X Innovation Center
- Biomimetic Innovations
- BiondVax
- BioNexus Gene Lab
- Bioqube Ventures
- BioRestorative Therapies
- BioSenic
- Bioservo Technologies
- Biosolution
- Biosplice
- Bioventus
- BioVinc
- BirchBioMed
- Bison & Rose
- Blueprint Medicines
- Boehringer Ingelheim
- Bone Biologics
- Bone Therapeutics
- Brain Canada
- Brickell Biotech
- BridgeBio Pharma
- Brigham and Women's Hospital
- Bristol-Myers Squibb
- Broad Institute
- Caerus Strength
- California Institute for Regenerative Medicine
- Calimmune
- Camargo Pharmaceutical Services
- Can-Fite BioPharma
- CANbridge Pharmaceuticals
- Capricor Therapeutics
- Capsigen
- CareFirst BlueCross BlueShield
- Carlsmed
- Carna BioSciences
- Cassie + Friends
- Catabasis Pharmaceuticals
- Catalent
- Catalyst Pharmaceuticals
- Cedars-Sinai Medical Center
- Celltech
- Cellthera Pharma
- Celltrion
- Cel Sci
- Centogene
- Century Therapeutics
- Cerhum
- CgBio
- Changshan Pharm
- Charles River Laboratories
- CheckPoint Immunology
- Children's Hospital Boston
- Children's Hospital of Philadelphia
- Children's Research Institute
- Chronolife
- Chugai Pharmaceutical
- CHU Sainte-Justine
- Cipla
- City of Hope
- CJ CheilJedang
- Clementia Pharmaceuticals
- CMS Medical
- Coapt
- Cocoon Biotech
- Codiak BioSciences
- Collaborative Trajectory Analysis Project
- Columbia University
- Columbia University Medical Center
- Conduit Pharmaceuticals
- ConforMIS
- Coracoid Solutions
- CRISPR Therapeutics
- CrystalGenomics
- CSIR-Central Drug Research Institute
- Cumberland Pharmaceuticals
- Curasan
- Cure Duchenne
- CURE Pharmaceutical
- CurveBeam AI
- CymaBay Therapeutics
- CytoMed Therapeutics
- Cytoo
- Cyxone
- Daewoong Pharmaceutical
- Dalhousie University
- Defense Advanced Research Projects Agency
- Delivra
- Delpor
- Denali Therapeutics
- Department of Defense
- Department of Veterans Affairs
- DePuy
- Distributed Bio
- Dr. Reddy's Laboratories
- Duchenne UK
- Duke University
- DuraStat
- Dynacure
- Dyne Therapeutics
- Dyno Therapeutics
- Echolight Medical
- ECM Therapeutics
- Ecole Polytechnique de Montreal
- EGeen
- Eisai
- Elanco
- Eli Lilly
- Emmyon
- Emory University
- Emovi
- Enable Injections
- ENCell
- Endo International
- Endo Ventures
- Energy Medicine Research Institute
- Enleofen Bio
- Entrada Therapeutics
- Enveric Biosciences
- Enzene Biosciences
- Equillium
- Ethos Research & Development
- Ethypharm
- Eureka Eurostars
- Eurofins LifeCodexx
- EVA Pharma
- Evonik Industries
- EVOQ Therapeutics
- Evotec
- Exagen Diagnostics
- ExCEEd Orphan
- Exicure
- Exonics Therapeutics
- Exothera
- Facio Therapies
- Factor Bioscience
- Feinstein Institute for Medical Research
- Fibrocell Science
- Fin-ceramica faenza spa
- Flexion Therapeutics
- Fluidigm
- Forbius
- Forge Biologics
- Frequency Therapeutics
- Fresenius Kabi Pharmaceuticals
- Friends of FSH Research
- FSHD Global Research Foundation
- FUJIFILM Cellular Dynamics
- Fujifilm Kyowa Kirin Biologics
- Fuji Yakuhin
- Fulcrum Therapeutics
- Galapagos
- Galderma
- Galecto
- Gebro Pharma
- GEn1E Lifesciences
- GenEdit
- GeneQuine Biotherapeutics
- General Electric (GE)
- Genethon
- Geneva Foundation
- Genevant Sciences
- Gennao Bio
- Genome BC
- Genome Canada
- Genome Insight
- Genosera
- George Washington University
- Gero
- Gilead Sciences
- GlycoNex
- GPCR Therapeutics
- Graminex
- Graviton Bioscience
- Gravocore
- Great Ormond Street Hospital (GOSH)
- Grunenthal
- GSK
- Guangzhou Ruianbo Pharmaceutical Technology
- Guangzhou Ruiao Biopharmaceutical Technology
- Haisco Pharmaceutical
- HanAll Pharmaceuticals
- Hansa Biopharma
- Hanuman Pelican
- Harbour Biomed
- Harvard University
- HAYA Therapeutics
- HealthSnap
- HealthTrio
- HemoShear
- Henlius Biotech
- High Line Bio
- Hikma Pharmaceuticals
- HistoIndex
- Horizon Europe
- Horizon Pharma plc
- Horizon Therapeutics
- Hospital for Special Surgery
- Howmedica Osteonics
- Human Life CORD Japan
- Icahn School of Medicine at Mount Sinai
- IDIPharma
- Idorsia
- IGEA Clinical Biophysics
- Iktos
- IM-Tech
- Image Analysis
- ImageBiopsy Lab
- Imcyse
- IMIDomics
- Immunis
- Immuthera
- Impressio
- In2Bones USA
- Incyte
- Indiana University
- Innosuisse
- Innovate UK
- Innovent Biologics
- Innovus Pharmaceuticals
- Inovalon
- Inserm
- Intas Pharmaceuticals
- Integrated Biosciences
- Intel
- Intellia Therapeutics
- International Spine Study Group Foundation
- Intrexon
- Inventiva
- Invibio Biomaterial Solutions
- Invitae
- Ionis Pharmaceuticals
- Ipsen
- IQVIA
- Ironwood Pharmaceuticals
- Italfarmaco
- Izana Bioscience
- Jain Foundation
- Janssen Pharmaceuticals
- Janssen Research & Development
- JCR Pharmaceuticals
- Jesse's Journey
- Jiangsu Aosaikang Pharmaceutical
- Jiangsu Hansoh Pharmaceutical
- Jiangsu Tainuo
- Johns Hopkins University
- Johnson & Johnson
- Johnson & Johnson Innovation
- Jolt Health
- Jubilant Radiopharma
- Jubilant Therapeutics
- Juniper Biologics
- Juvena Therapeutics
- JW Pharmaceutical
- Kali Therapeutics
- Kalytera Therapeutics
- Kansas State University
- Karolinska Institute
- Kashiv BioSciences
- Kawasaki Medical School
- Keck School of Medicine of USC
- Kelyniam Global
- Kennedy Institute of Rheumatology
- KeyBioScience
- KeyCare
- KFx Medical
- Kinea Bio
- Kiniksa Pharmaceuticals
- KiOmed Pharma
- Kitov Pharma
- Kolon Life Science
- Komodo Health
- Kowa Pharmaceuticals America
- Kuhnil Pharmaceuticals
- KYE Pharmaceuticals
- Kyowa Hakko Kirin
- Laboratories Acbel
- LABORATORIOS SAVAL
- Laurel Venture Capital
- Leadiant Biosciences
- Les Laboratoires Servier
- Level Brands
- Levolta Pharmaceuticals
- Lexicon Pharmaceuticals
- LG Chem
- Lima Corporate
- Link Health
- Lipocine
- Locana
- London School of Medicine and Dentistry
- Lonza
- Lucy Biotech
- Ludwig Institute for Cancer Research
- Lumicera Health Services
- Lupin
- Lynk Pharmaceuticals
- Maastricht University
- Mabwell Bioscience
- mAbXience
- MAIA Pharmaceuticals
- MainPointe
- Manoira Corporation
- Marathon Pharmaceuticals
- Marina Biotech
- Maryland Stem Cell Research Fund
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Max-Planck
- Max Biopharma
- Maxx Medical
- Maxx Orthopedics
- Mayo Clinic
- MC10
- McMaster University
- MDA Venture Philanthropy
- Medac
- Medacta
- Medexus Pharmaceuticals
- Mediar Therapeutics
- Medicardia Health
- Medidata Solutions
- MedImmune
- Medipost
- Medolife Rx
- MedShape
- Menarini
- Merck and Co
- Merck KGaA
- Mesoblast
- Mestag Therapeutics
- Metabolon
- Methuselah Foundation
- Metrion Biosciences
- MHC Medical Products
- Microdrop
- MiMedx
- Miravo Healthcare
- miRecule
- Mithra Pharmaceuticals
- Mitsubishi Tanabe Pharma
- Moebius Medical
- Momenta Pharmaceuticals
- MoonLake Immunotherapeutics
- Morphic Therapeutic
- Morris Animal Foundation
- MoveUP
- mSKIL
- MS Pharma
- MTF Biologics
- Mundipharma
- Muscle Activation Technique
- Muscular Dystrophy Association
- Musculoskeletal Transplant Foundation
- Mylan Laboratories
- Mylan Pharmaceuticals
- Myonexus Therapeutics
- MYOS
- Myriad Genetics
- myTomorrows
- Nano-X Imaging
- Nanotherapeutics
- National Human Genome Research Institute
- National Institute of Arthritis and Musculoskeletal Diseases
- National Institute on Aging
- National Institutes of Health
- National Science Foundation
- Nationwide Children’s Hospital
- Navidea Biopharmaceuticals
- Navitas
- NeoDynamics
- Nestle
- Neuro42
- Neurocrine Biosciences
- Neuronoff
- NeuroVive Pharmaceutical
- NeuX Technologies
- Nippon Shinyaku
- Nipro Corporation
- Nordic Bioscience
- Nordic Pharma Group
- Northway Biotechpharma
- Northwell Health
- Northwestern University
- NovaQuest
- Novartis
- NT Pharma
- Nuevolution
- Nuritas
- Nuvo Research
- nView Medical
- Ohio State Innovation Foundation
- Ohio State University
- OliX Pharmaceuticals
- OmniaBio
- OncoArendi Therapeutics
- Oncodesign
- Onkos Surgical
- Ono Pharmaceutical
- Open University of Israel
- OPUM
- Orebro University
- Organon
- Organovo
- Orthocell
- Orthofix Medical
- OrthoGrid Systems
- Orthopaedic Foot & Ankle Center
- Ortho Regenerative Technologies
- OrthoSensor
- Ortoma
- Osteolabs
- Osteopore International
- Oxford Biomedica Solutions
- Paladin Labs
- Palisade Bio
- Paragon 28
- ParcelShield
- Parent Project Muscular Dystrophy
- Parvizi Surgical Innovation
- Patient-Centered Outcomes Research Institute
- Pennsylvania State University
- PeptiDream
- PetVivo
- Pfenex
- Pfizer
- PharmaLegacy Laboratories
- Pharmanovia
- Pharmapark
- Poietis
- Precision BioSciences
- Pregene Biopharma
- Premier Inc
- Prevail Therapeutics
- Prime Therapeutics
- PrinterPrezz
- Prometheus Laboratories
- Promimic
- Propella Therapeutics
- Proprio
- Provider Network of America
- PTC Therapeutics
- pt Health
- Purdue Pharma
- Purdue Research Foundation
- QED Therapeutics
- QuantHealth
- Queen Mary University of London
- Quest Diagnostics
- Radius Health
- Radius Pharmaceuticals
- Rainbow Medical
- Ramot at Tel Aviv University
- Rani Therapeutics
- Rebel Edibles
- Recombinetics
- Recursion
- Regen BioPharma
- Regeneron Pharmaceuticals
- Regeneus
- Regenstrief Institute
- Regenxbio
- Relation Therapeutics
- Remedium Bio
- Remission Medical
- Replicel Life Sciences
- Restoration Biologics
- RevBio
- ReveraGen BioPharma
- Revive Therapeutics
- Revolo Biotherapeutics
- Rheumatology Research Foundation
- Ribon Therapeutics
- Rigenerand
- Riptide Bioscience
- RMX Biopharma
- Roche
- Rocket Pharmaceuticals
- Roivant Sciences
- ROMEG Therapeutics
- RoosterBio
- Saint Louis University
- Samsung Bioepis
- Sanara MedTech
- Sandoz
- Sangamo Therapeutics
- Sanguine
- Sanofi
- Santhera Pharmaceuticals
- Saphetor
- Sarcomatrix Therapeutics
- Sarepta Therapeutics
- Satellos Bioscience
- Sayre Therapeutics
- Scipher Medicine
- Scribe Therapeutics
- Scripps Research Institute
- Scriptr Global
- Second Genome
- SecondWave Systems
- Seikagaku
- Selecta Biosciences
- Serenus.AI
- Shionogi
- Shriners Hospital for Children
- Si-Bone
- Simcere Pharmaceuticals
- SimonMed Imaging
- Singapore Sengkang General Hospital
- SiSaf
- Sites Medical
- Skyhawk Therapeutics
- Sleip
- SmartCella
- Smith & Nephew
- Solid Biosciences
- Solve GNE
- SomaLogic
- Somite Therapeutics
- Sorrento Therapeutics
- Southwest Research Institute
- Southwest Transplant Alliance
- Spotlight Innovation
- SQI Diagnostics
- STADA Arzneimittel
- Standigm
- Stempeutics
- Storm ID
- Strand Life Sciences
- StrideBio
- StrongPath
- Strykagen
- Stryker
- Summit Therapeutics
- Sun Pharmaceutical
- Sway Medical
- Swedish Bactiguard
- Swedish Orphan Biovitrum
- SynAct Pharma
- Synpromics
- Synthego
- Tabuk Pharmaceutical
- Taiwan Liposome Company
- Takeda Pharmaceutical
- Technomark Life Sciences
- Teijin
- Teikoku Seiyaku
- Telomir Pharmaceuticals
- TeraRecon
- Teva Pharmaceutical Industries
- Teva Pharmaceuticals USA
- Tevard Biosciences
- Texas Christian University
- The Arthritis Society
- The Cyprus Institute of Neurology and Genetics
- Theradaptive
- Theramex
- Thermo Fisher Scientific
- THINK Surgical
- Thuasne and Townsend Design
- TissueGene
- Tissue Genesis
- Tissue Regenix
- TiumBio
- TLC BioSciences
- Toshiba Medical Systems Corporation
- Total Joint Orthopedics
- Tow Foundation
- TR-Pharm
- TracPatch Health
- Transcenta
- Transdermal Delivery Solutions
- TRB Chemedica
- TrialSpark
- Tufts University
- Turner Imaging Systems
- UCB
- Ultragenyx Pharmaceuticals
- Unilife
- United Orthopedic Group
- University Gottingen
- University of Basel
- University of Bern
- University of British Columbia
- University of California
- San Diego (UCSD) School of Medicine
- University of California Berkeley
- University of California Irvine
- University of California Los Angeles
- University of California San Francisco
- University of Florida
- University of Illinois
- University of Illinois Urbana-Champaign
- University of Iowa
- University of Kansas
- University of Lausanne
- University of Liverpool
- University of L’Aquila
- University of Maryland Baltimore
- University of Massachusetts Medical School
- University of Miami
- University of Michigan
- University of Minnesota
- University of Missouri
- University of Ottowa
- University of Oxford
- University of Pennsylvania
- University of Pittsburgh
- University of Sydney
- University of Texas Southwestern Medical Center
- University of Vermont
- University of Verona
- University of Virginia
- University of Washington
- University of Western Australia
- Urica Therapeutics
- US Army
- Vandria
- Variant Bio
- V ClinBio
- Verge Genomics
- Verily
- VeriSIM Life
- Verity Pharmaceuticals
- Vertex Pharmaceuticals
- VetStem
- VIB
- Victoria University
- Virginia Commonwealth University
- Virpax Pharmaceuticals
- Viscogliosi Brothers
- Vitalli Bio
- Vita Therapeutics
- Vizient
- Voronoi
- Voyager Therapeutics
- Walloon Region Investment Fund
- Weill Cornell Medical College
- WellDyne
- William Harvey Research Instutute
- WishBone Medical
- WorldCare Clinical
- WuXi Biologics
- Xlife Sciences
- Yale University
- Yposkesi
- Zebra Medical Vision
- Zentiva
- Zimmer Biomet
- Zoetis
Methodology
- The publisher reports provide insight into the trends and terms of partnering deals in the global life sciences sector.
- The publisher reports are updated every six months to ensure the user has access to the latest announcements and trends in the topic focus of the report.
- The publisher analysts review the deal data to provide an overview and analysis of deal trends, including example deals and terms.
- The publisher reports source deal data from our proprietary deals and alliances database. The database is updated daily by our analysts with new deals as they are announced globally by the company’s party to the deal.
- The data in the deals and alliances database is obtained from secondary sources such as publicly available industry sources including press releases, company presentations, investor presentations, company SEC filings, other company filings, company websites, conference presentations. Sources are identified to allow for user verification.
The publisher provides comprehensive coverage of the following partnering or deal types:
- Asset purchase
- Assignment
- Co-development
- Co-market
- Co-promotion
- Collaborative R&D
- Contract service
- CRADA
- Cross-licensing
- Development
- Distribution
- Equity purchase
- Evaluation
- Grant
- Joint venture
- Licensing
- Loan
- Manufacturing
- Marketing
- Option
- Promotion
- Research
- Royalty financing
- Settlement
- Spin out
- Sub license
- Supply
- Termination
- Warrant
Every deal record is fully categorized and includes the following data, where available:
- Industry sector
- Therapy areas
- Technology type
- Deal components
- Financial terms
- Stage of development
- Exclusivity
- Asset type
- Geographic focus
- Excluded geography
- Company press release
- SEC filing data including contract document
All financial amounts are converted to US$ using the exchange rate available on the date of deal announcement, enabling direct comparison of deal terms across international territories.
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