Glycobiology of the Immune Response, Volume 1253. Annals of the New York Academy of Sciences

  • ID: 2245323
  • Book
  • Region: New York
  • 252 Pages
  • John Wiley and Sons Ltd
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Carbohydrates are ubiquitous, essential molecules, as important as nucleic acids and proteins yet less well understood.  Mounting data demonstrate that microbial and mammalian glycans and their protein–binding partners (lectins) play central roles in all innate and adaptive immune responses.  Indeed, programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation.  Glycobiology of the Immune Response explores the integration of state–of–the–art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system

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Glycobiology of immune responses 1Gabriel A. Rabinovich, Yvette van Kooyk and Brian A. Cobb

Multifarious roles of sialic acids in immunity 16Ajit Varki and Pascal Gagneux

Siglecs as sensors of self in innate and adaptive immune responses 37James C. Paulson, Matthew S. Macauley and Norihito Kawasaki

Interleukin–2, Interleukin–7, T cell–mediated autoimmunity, and N–glycosylation 49Ari Grigorian, Haik Mkhikian and Michael Demetriou

T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival 58Mary C. Clark and Linda G. Baum

Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells 68Bo Pei, Jose Luis Vella, Dirk Zajonc and Mitchell Kronenberg

Gelectins in acute and chronic inflammation 80Fu–Tong Liu, Ri–Yao Yang and Daniel K. Hsu

Mechanisms underlying in vivo polysaccharide–specific immunoglobulin responses to intact extracellular bacteria 92Clifford M. Snapper

CD33–related siglecs as potential modulators of inflammatory responses 102Paul R. Crocker, Sarah J. McMillan and Hannah E. Richards

Sulfated glycans control lymphocyte homing 112Hiroto Kawashima and Minoru Fukuda

Acute phase glycoproteins: bystanders or participants in carcinogenesis? 122Eugene Dempsey and Pauline M. Rudd

Glycans, galectins, and HIV–1 infection 133Sachiko Sato, Michel Ouellet, Christian St–Pierre and Michel J. Tremblay

An evolutionary perspective on C–type lectins in infection and immunity 149Linda M. van den Berg, Sonja I. Gringhuis and Teunis B. H. Geijtenbeck

Integrated approach toward the discovery of glycol–biomarkers of inflammation–related diseases 159Takashi Angata, Reiko Fuijinawa, Ayako Kurimoto, Kazuki Nakajima, Masaki Kato, Shinji Takamatsu, Hiroaki Korekane, Cong–Xiao Gao, Kazuaki Ohtsubo, Shinobu Kitazume and Naoyuki Taniguchi

Novel roles for the IgG Fc Glycan 170Robert M. Anthony, Fredrik Wermeling and Jeffrey V. Ravetch

The effect of galectins on leukocyte trafficking in inflammation: sweet or sour? 181Dianne Cooper, Asif J. Iqbal, Beatrice R, Grittens, Carmela Cervone and Mauro Perretti

Engineering cellular trafficking via glycosyltransferase–programmed stereosubstitution 193Robert Sackstein

The expanding role of 2–3 sialylation for leukocyte trafficking in vivo 201Markus Sperandio

Beyond glycoproteins as galectin counterreceptors: effector T cell growth control of tumors via ganglioside GM1 206Robert W. Ledeen, Gusheng Wu, Sabine André, David Bleich, Guillementte Huet, Herbert Kaltner, Jürgen Kopitz and Hans–Joachim Gabius

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Polarization of host immune responses by helminth–expressed glycansDonald Harn Jr., Smanla Tundup and Leena Srivastava

Carbohydrate–recognition in the immune system: contributions of NGL–based microarrays to ligand discovery Ten Feizi

Diversity in recognition of glycans by F–type lectins and galectins: molecular, structural, and biophysical aspects Gerardo R. Vasta, Hafiz Ahmed, Mario A. Bianchet, José A. Fernández–Robledo and L. Mario Amzel

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Glycobiology of the Immune Response explores the integration of state–of–the art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system.   (European Journal of Immunology, 1 December 2012)

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