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Cancer Stem Cells

  • ID: 2392748
  • Book
  • 552 Pages
  • John Wiley and Sons Ltd
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Cancer Stem Cells covers a wide range of topics in cancer stem cell biology, including the functional characteristics of cancer stem cells and how they′re generated, where they are localized, the means by which cancer stem cells can be targeted, and how cancer stem cells can be reprogrammed back at least epigenetically  into non–tumor forming cells.

The book builds systematically from coverage of the basic research stage to an advanced research level, from clinical relevance to therapeutic potential, and will be a valuable resource for professionals in the fields of cancer research and stem cell biology.

"This book is both an elegant review and a practical guide to the exciting, and still largely uncharted, world of cancer stem cells. I praise the editor and the authors for this wonderful endeavor, rich of provocative ideas and challenging concepts, not only for a better understanding of basic cancer biology, but also for the future development of new, more effective, anti–tumor treatments."
Michael F. Clarke, MD., Stanford University

"This authoritative book, written by a range of world–leading cancer researchers, provides a comprehensive overview of the cancer stem cell, its microenvironment, and how these insights will lead to novel clinical strategies."
Hans Clevers, MD., PhD., Hubrecht Institute, Utrecht

"For those wanting to stay abreast of the field from a basic as well as a clinical perspective, this book will be a welcome read and resource."
Connie J. Eaves, PhD., FRSC., Terry Fox Laboratory, Vancouver

"This volume reports on many aspects of these cells in a variety of human tumors, justifying the notion that CSCs are likely to be important players in virtually all types of human tumors."
Robert A. Weinberg, PhD., Whitehead Institute, Massachusetts Institute of Technology

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About the Editor xi

Contributors xiii

Foreword xxi

Preface xxiii

Acknowledgments xxxv

Section I Essentials of Cancer Stem Cells and Conceptual Modeling 1

1 Theoretical and Experimental Foundations of the "Cancer Stem Cell" Model 3Pradeep S. Rajendran and Piero Dalerba

2 The Hallmarks of Prostate Cancer Stem Cells 17Norman J. Maitland and Anne T. Collins

3 Self–Renewal, Induced Proliferation, and Autonomous Cell Growth Represent Distinct Modes of Cell Multiplication: Relevance to the Cancer Stem Cell Theory 39Dov Zipori

4 Human Embryonic Stem Cells and Cancer: Modeling Disease in a Dish 49Tamra Werbowetski–Ogilvie and Robyn McClelland

5 Cancer Stem Cell as a Result of a Reprogramming–Like Mechanism: Implications in Tumor Development and Treatment 61J.M. Iglesias, Idoia Garcia–Ramirez, Alberto Martin–Lorenzo, L. Vellon, Lucia Ruiz–Roca, A.G. Martin, and Isidro Sanchez–Garcia

6 A Cancer Stem Cell Model: An Insight into the Conversion of Induced Pluripotent Stem Cells to Cancer Stem–Like Cells 79Akifumi Mizutani, Ling Chen, Tomonari Kasai, Takayuki Kudoh, Hiroshi Murakami, Li Fu, and Masaharu Seno

7 Altruistic Stem Cells and Cancer Stem Cells 89Bikul Das

8 The Emerging Concept of EMT–Induced Cancer Stem Cells 107Jeremy Bastid

9 Models to Study Chronic Myeloid Leukemia Cancer Stem Cells 119Sheela A. Abraham, Lisa Hopcroft, Ravi Bhatia, Steffen Koschmieder, Anthony D. Whetton, and Tessa L. Holyoake

10 Cancer Stem Cells in Melanoma: Biomarkers and Mathematical Models 133Stefano Zapperi and Caterina A.M. La Porta

Section II Stem Cells in Liquid Tumors 143

11 Acute Myeloid Leukemia Stem Cells Updates and Controversies 145Stephen S. Chung and Christopher Y. Park

12 Leukemia–Initiating Cells in Acute Lymphoblastic Leukemia 161Thorsten Raff and Monika Brüggemann

Section III Stem Cells in Solid Tumors 171

13 Lung Cancer Stem Cells and Resistance to Radiotherapy 173Scott V. Bratman and Maximilian Diehn

14 Prostate Cancer Cell Heterogeneity and Prostate Cancer Stem Cells 183Mark A. Badeaux and Dean G. Tang

15 Glioblastoma Stem Cells Drive Tumor Recurrence and Patient Relapse: What′s the Evidence? 193Aneet Mann, Randy van Ommeren, Branavan Manoranjan, Nicole McFarlane, Parvez Vora, Chitra Venugopal, and Sheila Singh

16 Stem Cells and Pancreatic Cancer 209Susana Garcia–Silva and Christopher Heeschen

17 Melanoma Subpopulations with Cancer Stem Cell Phenotypes 223Rajasekharan Somasundaram, Nicole Facompre, and Meenhard Herlyn

18 Sarcoma Stem Cells 235Filemon S. Dela Cruz and Igor Matushansky

Section IV Cancer Stem Cells in Tumor Metastasis Perspective 247

19 Cancer Stem Cells in Metastasis and Minimal Residual Disease 249Joerg Huelsken and Albert Santamaria i Martinez

20 Role of Cancer Stem Cells in Metastasis 259Giovanna Merchand–Reyes, Rosana Pelayo, Lenin Pavón, Richard G. Pestell, and Marco Velasco–Velázquez

21 Cancer Stem Cells and the Stromal Microenvironment 273Li Li and David A. Margolin

22 A Perspective on Breast Cancer Malignant Progression: From Cancer Stem Cell Intra Tumor Heterogeneity to Metastasis–Initiating Cells 287Pasquale Sansone, Vinagolu K. Rajasekhar, and Jacqueline Bromberg

Section V Novel and Potential Targets in Cancer Stem Cells 295

23 Targeting Cancer Stem Cells Modulating Embryonic Stem Cell Signaling, Epigenetics, and Tumor Metabolism 297Naoko Takebe, Pamela Jo Harris, Yutaka Kondo, Abhilasha Nair, S. Percy Ivy, and Hideyuki Saya

24 Oct4, Oct1, and Cancer Stem Cells 319Jessica Maddox and Dean Tantin

25 The Role of Cripto–1 in Cancer and Cancer Stem Cells 331Hideaki Karasawa, Nadia P. Castro, Maria Cristina Rangel, and David S. Salomon

26 Leptin Signaling in the Regulation of Stem and Cancer Stem Cells 347Shanchun Guo, Keshav K. Singh, James W. Lillard, and Lily Yang

27 Tumor–Initiating Stem–Like Cells: Carcinogenesis through Toll–Like Receptors, Environmental Factors, and Virus 361Keigo Machida

28 The Role of Epithelial Cell Polarity Pathways on Cancer Stem Cells 373Inmaculada Banon–Rodriguez, Ilenia Bernascone, and Fernando Martin–Belmonte

29 Cancer–Initiating Cells, Exosomes, and the Premetastatic Niche 389Margot Zöller

30 MicroRNA Therapeutics to Target Brain Tumor Stem Cells 403Derryn Xin Hui Chan, Srikanth Nama, Gopinath Sundaram, and Prabha Sampath

31 The Riboproteome Orchestrates Self–Renewal and Cell Fate in Leukemia 417Elianna M. Amin and Michael G. Kharas

Section VI Clinical Relevance of Cancer Stem Cells in Patients 435

32 Targeting Different States of Breast Cancer Stem Cells 437Sean P. McDermott and Max S. Wicha

33 Difficulties in Targeting the Beating Heart: Therapeutic Implications of the Cancer Stem Cell Hypothesis in Melanoma 451Jennifer Makalowski and Hinrich Abken

34 Targeting Cancer Stem Cells for Overcoming Drug Resistance and Cancer Progression 461Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar

35 The Role of Cancer Stem Cells in Tumor Radioresistance 473I. Kurth, C. Peitzsch, M. Baumann, and A. Dubrovska

Index 493

Color plate located between pages 222 and 223.

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Vinagolu K. Rajasekhar
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