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Textbook of Influenza. 2nd Edition

  • ID: 2500233
  • Book
  • 520 Pages
  • John Wiley and Sons Ltd
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The Textbook of Influenza is a comprehensive resource covering all aspects of influenza, from the genetic and molecular biology of the virus through to clinical aspects of the disease and the latest drug developments and treatments. This new edition has been completely revised and reflects the integration of disciplines concerning the emergence, evolution, pathogenesis and control of influenza viruses in the field of human and veterinary public health.

Textbook of Influenza examines the lessons learnt from the latest pandemic and provides the current state of knowledge for many yet unresolved issues related to virus origin, spread, pathogenesis and disease severity to better prepare for future pandemics. It covers the background to recent advances in influenza genomics and reverse genetics which have allowed the identification of virus virulence factors and the analysis and reconstruction of influenza viruses such as the 1918 Spanish flu strain.

This new edition is divided into eight key sections, containing chapters co–written by international experts from both the clinical and scientific communities, covering:
 Influenza Perspectives
 Structure and Replication
 Evolution and Ecology
 Epidemiology and Surveillance
 Vaccines and Vaccine Development
 Clinical Aspects and Antivirals
 Public Health

Textbook of Influenza is for all those working in the area of influenza including clinical and basic scientists, immunologists, molecular and structural virologists, public health officials and global pandemic control planners.

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List of contributors, ix

Foreword to the second edition, xiv

Preface to the second edition, xvi

Acknowledgments, xvii

PART 1 Influenza: Perspective

1 Human influenza: One health, one world, 3Daniel B. Jernigan and Nancy J. Cox

2 Influenza pandemics: History and lessons learned, 20Arnold S. Monto and Robert G. Webster

PART 2 Structure and replication

3 Structure, disassembly, assembly, and budding of influenza viruses, 37Debiprosad Nayak, Sakar Shivakoti, Rilwan A. Balogun, Gwendolyn Lee, and Z. Hong Zhou

4 The virus genome and its replication, 57Robert M. Krug and Ervin Fodor

5 Influenza glycoproteins: Hemagglutinin and neuraminidase, 67Rupert J. Russell, Steven J. Gamblin, and John J. Skehel

6 Proton channels of influenza A and B viruses, 101Chunlong Ma, Lawrence H. Pinto, and Robert A. Lamb

7 The NS1 protein: A master regulator of host and viral functions, 114Robert M. Krug and Adolfo García–Sastre

8 Structure and function of the influenza virus replication machinery and PB1–F2, 133Andrew Mehle and Jonathan A McCullers

9 The genome and its manipulation: Recovery of the 1918 virus and vaccine virus generation, 146Gabriele Neumann and Yoshihiro Kawaoka

10 Pathogenesis, 157Hans Dieter Klenk, Wolfgang Garten, and Mikhail Matrosovich

PART 3 Evolution and ecology of influenza viruses

11 Ecology and evolution of influenza viruses in wild and domestic birds, 175Ron A.M. Fouchier and Yi Guan

12 Influenza in swine, 190Richard Webby and Juergen Richt

13 Equine/Canine/Feline/Seal influenza, 203Thomas M. Chambers, Edward J. Dubovi, and Ruben O. Donis

14 Emergence and Evolution of the 1918, 1957, 1968, and 2009 pandemic virus strains, 218Taia T. Wang and Peter Palese

PART 4 Epidemiology and surveillance

15 Influenza surveillance and laboratory diagnosis, 231Maria Zambon

16 Epidemiology of influenza, 250Marc–Alain Widdowson and Arnold S. Monto

PART 5 Immunology of influenza

17 Innate immunity, 269Akiko Iwasaki and Malik Peiris

18 Antibody–mediated immunity, 283Nicole Baumgarth,Michael C. Carroll, and Santiago Gonzalez

19 Cell–mediated immunity, 298Stephen J. Turner, Peter C. Doherty, and Anne Kelso

PART 6 Vaccines and vaccine development

20 Immunogenicity, efficacy of inactivated/live virus seasonal and pandemic vaccines, 313Wendy A. Keitel, Kathleen M. Neuzil, and John Treanor

21 New approaches to vaccination, 327Chih–Jen Wei, Damian C. Ekiert, Gary J. Nabel, and Ian A. Wilson

22 Control of influenza in animals, 337Ilaria Capua and Dennis J. Alexander

23 Influenza vaccine production, 352Klaus Stöhr

PART 7 Clinical aspects and antivirals

24 Human influenza: Pathogenesis, clinical features, and management, 373Frederick G. Hayden and Menno D. de Jong

25 Antivirals: Targets and use, 392Michael G. Ison and Alan Hay

26 The control of influenza and cost–effectiveness of interventions, 419Carolyn B. Bridges, Samuel K. Peasah, and Martin I. Meltzer

27 Applications of quantitative modeling to influenza virus transmission dynamics, antigenic and genetic evolution, and molecular structure, 434Marc Lipsitch and Derek Smith

28 Pandemic preparedness and response, 453Jonathan S. Nguyen–Van–Tam and Joseph Bresee

29 Influenza: The future, 470Thomas J. Braciale

PART 8 The outbreak of H7N9

30 Appendix, 479Thomas J. Bracial

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Robert G. Webster
Arnold S. Monto
Thomas J. Braciale
Robert A. Lamb
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