Therapeutic Strategies in Cancer Biology and Pathology

Table of Contents

Introduction

Part I:  RNA interference in genetic regulation 1. The biogenesis and functions of microRNAs 2. Association of miRNAs with pathogenesis 3. Are miRNAs suitable targets for cancer therapy?

Part II: EMT associated gene targeting 4. Hedgehog signalling in EMT 5. Targeted inhibition of Hh, Wnt, TGF-ß signalling complex 6. Encountering aberrant Wnt signalling 7. Therapeutic targeting of TGF-ß signalling 8. EGFR signalling in EMT

Part III: Therapeutic deployment of tumour and metastasis promoter gene function 9. S100A4 as a potential target 10.  MTAs in cancer invasion and metastasis

Part IV: Genetic determinants of tumour and metastasis suppression 11.  Metastasis suppressor gene nm23 and manipulation of its expression 12.  The metastasis suppressor KiSS-1 gene 13.  KAI1 (CD82) suppresses metastasis, cell proliferation and invasion 14.  14-3-3 proteins in normal and tumour cell biology 15.  Suppressor function of NDRG1 (N-myc downstream-regulated gene-1) 16.  The ING (inhibitor of growth) suppressor gene 17.  The BRCA1 and BRCA2 suppressor genes 18.  BRMS1 (breast cancer metastasis suppressor 1) gene 19.  Maspin, a postulated tumour suppressor 20.  EPB41L3 and CADM1 tumour suppressor function

Part V: Signalling and transcription regulators as prospective candidates 21.  Is MKK a metastasis suppressor? 22.  RKIP (The Raf kinase inhibitor protein) suppresses invasion and metastasis) 23.  CRSP3 metastasis suppressor 24.  The suppressor function of TXNIP (Thioredoxin interacting protein-2) 25.  The essence of the Hippo signalling system 26.  HIC1 (hypermethylated in cancer 1) suppressor gene 27.  The DLC suppressor genes 28.  The LKB1 (STK11) suppressor gene 29.  PLCD1 (phospholipase Cd1) suppresses tumorigenesis 30.  Inhibitor of DNA binding proteins (IDs) in tumours 31.  PDCD4 (Programmed Cell Death 4)

Epilogue

Authors

Gajanan V. Sherbet Professor, Institute for Molecular Medicine, Huntington Beach CA, USA and Professor (visiting), School of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK. Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet's major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.