Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.
- Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.
- Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.
Introduction 1. Historical Overview
Methodological Approaches and Background 2. Expression Arrays (SNPs, etc.) 3. Tissue micro-arrays (breast, ovarian) 4. Next generation sequencing (DNAseq) 5. RNAseq (breast cancer, sarcomas) 6. Epigenetic Analyses 7. Pharmcogenomics 8. Biomarker discovery through genomics 9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 10. Bioinformatics and computational methods for data analysis 11. Genomic Resource Projects
The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC)
Ethics of Genomics Research 12. Ethics of Genomics Research
The Genomics, Epigenomics and Transcriptomics of Cancer 13. Somatic mutations, Transcription and Epigenetics Overview
Adult Solid Tumors 14. Lung Cancer 15. Breast Cancer 16. Prostate Cancer 17. Colon Cancer 18. Thyroid Cancer
Age Non-specific Tumors and Hematopoietic Malignancies 19. ALL 20. AML 21. NHL 22. Multiple Myeloma 23. Brain Tumors
Pediatric Cancers 24. Neuroblastoma 25. Soft tissue sarcomas 26. Osteosarcoma 27. Wilms Tumors
Germline Mutations and Hereditary Cancer Syndromes 28. Germline Mutations and Hereditary Cancer Syndromes
Future Directions 29. The role of microRNAs and ultraconserved non-coding RNAs in cancer 30. Environmental impact on cancer genomics