Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye.
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Table of Contents
List of figures and tables
About the authors
Chapter 1: Eye: anatomy, physiology and barriers to drug delivery
Abstract:
1.1 Introduction
1.2 Anatomy and physiology of the eye
1.3 Barriers to ocular drug delivery
1.4 Conclusions
1.5 Acknowledgements
Chapter 2: Biology of ocular transporters: efflux and influx transporters in the eye
Abstract:
2.1 Introduction
2.2 SLC transporters
2.3 ABC transporters
2.4 Conclusions
Chapter 3: Characterization of ocular transporters
Abstract:
3.1 Introduction
3.2 Molecular and cellular characterization
3.3 Functional characterization of transporters
Chapter 4: Transporters and receptors in the anterior segment of the eye
Abstract:
4.1 Introduction
4.2 Transporters and receptors
4.3 Anterior chamber influx transporters
4.4 Anterior chamber efflux transporters
4.5 Anterior chamber receptors
4.6 Other miscellaneous anterior chamber receptors
4.7 Conclusions
Chapter 5: Transporters and receptors in the posterior segment of the eye
Abstract:
5.1 Introduction
5.2 Influx transporters in posterior segment of the eye
5.3 Receptors in posterior segment of the eye
5.4 ABC transporters
5.5 Conclusion
Chapter 6: Transporters in drug discovery and delivery: a new paradigm in ocular drug design
Abstract:
6.1 Introduction
6.2 Transporter-targeted drug delivery to the anterior segment
6.3 Transporter-targeted drug delivery to the posterior segment
6.4 Conclusion
Chapter 7: Transporter-metabolism interplay in the eye
Abstract:
7.1 Introduction
7.2 Metabolizing enzymes in ocular tissues
7.3 Impact of disease state on the expression of metabolizing enzymes
7.4 Efflux transporters and metabolism interplay
7.5 Potential impact of the efflux metabolism interplay in ocular bioavailability
7.6 Drug design and formulation strategies to overcome the efflux and metabolism interplay
7.7 Conclusion
Index
