The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.
- Internationally renowned scientists describe cutting edge research on the neurobiological response to traumatic brain injury, including descriptions of potential biomarkers and indicators of potential targets for treatments to reduce the impact of the injury
- Explores cellular and molecular mechanisms as well as genetic predictors of outcome
- Offers coverage of various diagnostic tools - CT, MRI, DDTI, fMRI, EEG, resting functional imaging, and more
- State-of-the-art traumatic brain injury management and treatment principles are presented for both civilian and military care
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Section 1 Risk and Predisposition 1. Epidemiology 2. Classification of traumatic brain injury: past, present and future 3. Genetic predictors of outcome following TBI
Section 2 Pathology and Mechanisms of Traumatic Brain Injury 4. The neuropathology of traumatic brain injury 5. Cellular and Molecular Mechanisms of Injury and Spontaneous Recovery 6. Injury biomechanics, neuropathology, and simplified physics of explosive blast and impact mild traumatic brain injury 7. Cellular biomechanics of central nervous system injury 8. Animal models of traumatic brain injury
Section 3 Special Considerations 9. Mild traumatic brain injury 10. Acute sports-related traumatic brain injury and repetitive concussion 11. Brain injury from explosive blast: description and clinical management 12. Surgical management of civilian gunshot wounds to the head 13. Acute Loss of Consciousness 14. Systemic manifestations of traumatic brain injury 15. Special Considerations in Infants and Children
Section 4 Current and Emerging Diagnostic Tools 16. Biomarkers 17. Current and future diagnostic tools for traumatic brain injury: CT, conventional MRI, and diffusion tensor imaging 18. Using fMRI and EEG to detect consciousness after severe brain injury 19. Resting Functional Imaging Tools: (MRS, SPECT, PET and PCT) 20. Advances in imaging explosive blast mild traumatic brain injury 21. Electrophysiological recordings in traumatic brain injury
Section 5 Management and Treatment 22. Neuroprotection for traumatic brain injury 23. The prehospital management of traumatic brain injury 24. Acute Management of Military-Related Injury (PHI & Blast) 25. Clinical Management of the Minimally Conscious State 26. Rehabilitation after traumatic brain injury 27. Long-Term Social Integration and Community Support 28. Recent developments in clinical trials for the treatment of traumatic brain injury
Jordan Grafman, PhD, is director of Brain Injury Research at the Rehabilitation Institute of Chicago. Before joining RIC, Dr. Grafman was director of the Traumatic Brain Injury Research at Kessler Foundation. His investigation of brain function and behavior contributes to advances in medicine, rehabilitation, and psychology, and informs ethics, law, philosophy, and health policy. His study of the human prefrontal cortex and cognitive neuroplasticity incorporates neuroimaging and genetics, an approach that is expanding our knowledge of the impact of traumatic brain injury, as well as other diseases that impair brain function, such as stroke, multiple sclerosis and degenerative diseases. Dr. Grafman aims to translate his research into more effective, targeted rehabilitation to achieve the best outcomes for people with cognitive disabilities. Dr. Grafman's background includes 30 years of experience in brain injury research. He has studied brain function in dementia, depression, and degenerative neurological diseases, as well as TBI. He has authored more than 300 research publications, co-editor of the journal Cortex, and provides peer review for numerous specialty journals. At the National Institutes of Health, he served as chief of the Cognitive Neuroscience Section at the National Institute of Neurological Disorders and Stroke. While in the US Air Force, he served at Walter Reed Army Medical Center as neuropsychology chief of the Vietnam Head Injury Project, a long-term study of more than 500 soldiers with serious injuries of the head and brain. He is the leading expert on the long-term effects of penetrating brain injuries in military personnel. His expertise includes the scope of challenges faced during recovery, including behavioral changes like aggression, late sequelae such as seizures, and the impact on TBI on family life and employment, and legal implications. He is an elected fellow of the American Psychological Association and the New York Academy of Sciences. Dr. Grafman is the recipient of many prestigious awards including the Department of Defense Meritorious Service Award, the National Institutes of Health Award of Merit, 2010 National Institutes of Health Director's Award, and the Humboldt Reserach Award. He is a frequent speaker at national and international conferences. His expert opinion is often sought by national media on issues related to brain function and behavior, cognitive rehabilitation, and policy and legal issues related to brain-behavior research.
Salazar, Andres M.
Andres M. Salazar, MD, is CEO, Scientific Director and cofounder of Oncovir, Inc., a pharmaceutical company developing the immunomodulator, Hiltonol® (Poly-ICLC). He is a retired US Army Colonel and formerly Professor of Neurology at USUHS. He was Director of the Vietnam Head Injury Study and Founder, Principal Investigator, and first Director of the Defense and Veterans Head Injury Program, an ongoing U.S. National Head Injury clinical management and research effort. His research background includes neurotraumatology, neurodegenerative diseases, multiple sclerosis (MS), AIDS, and Oncology. He has over 200 publications, several patents, and has conducted multiple clinical studies, including in head injury, AIDS, pilot and pivotal clinical trials of beta-interferon (Avonex) in multiple sclerosis, and clinical trials of Hiltonol® in various cancers, MS, and AIDS. Dr. Salazar is a graduate of Dartmouth College and Jefferson Medical College. He completed Neurology training at Walter Reed Army Medical Center, and a Neurovirology Fellowship at the CNSSL, National Institutes of Health, Bethesda, MD.