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Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech & Diagnostics 2014-2020

  • ID: 2907761
  • Report
  • April 2020
  • Region: Global
  • 2500 Pages
  • CurrentPartnering
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FEATURED COMPANIES

  • 10X Genomics
  • Amoy Diagnostics
  • Beam Therapeutics
  • Canndeo
  • Congenica
  • Dyadic International
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The Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 report provides comprehensive understanding and unprecedented access to the collaborative R&D deals and agreements entered into by the worlds leading life science companies.

This report provides details of the latest collaborative R&D deals announced in the pharmaceutical, biotechnology and diagnostic sectors. Fully up to date with the latest information, the report provides details of collaborative R&D deals from 2014 to 2020.

There has been a long standing willingness for parties to enter collaborative R&D deals. Such deals enable both parties to benefit from the upside of a big R&D win, whilst mitigating the risks of going it alone in the risky preclinical and clinical development stages.

Collaborative R&D is a specific type of partnering deal whereby the parties to the deal agree to collaborate on the research and development and subsequently commercialize a compound, product or technology.

There are several forms of a collaborative R&D deal; A traditional collaborative R&D arrangement whereby an owner of intellectual property (the licensor) provides access to its technology to another company (the licensee) in return for agreed payments and royalties on subscequent sales of product(s) derived from the intellectual property.

In more recent times, licensing is often the outcome of a successful period of collaborative R&D on the research and development of a technology or compound, resulting in a product which can be commercialized. In this situation, the collaborative R&D agreement governs who has permission to commercialize and what payments are due should commercialization proceed.

The report provides a detailed understand and analysis of how and why companies enter collaborative R&D deals. The majority of deals are multicomponent whereby the licensee retains either a right or option to license to comoercialize the resultant product of the research collaboration. There are also numerous pure licensing deals whereby the products originator takes on a development/commercialization partner in order to maximize a technologies/products prospects.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payment clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.

This report contains a comprehensive listing of all collaborative R&D deals announced since 2014 as recorded in the Current Agreements deals and alliances database, including financial terms where available, plus links to online copies of actual collaborative R&D contract documents as submitted to the Securities Exchange Commission by companies and their partners.

Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of collaborative R&D dealmaking and business activities.

Chapter 1 provides an introduction to the report, whilst chapter 2 provides an analysis of the trends in collaborative R&D as well as a discussion on the merits of the type of deal.

Chapter 3 provides an overview of the structure of collaborative R&D deals. The chapter includes numerous case studies to enable understanding of both pure collaborative R&D deals and multicomponent deals where collaborative R&D forms a part.

Chapter 4 provides a review of the leading collaborative R&D deals since 2014. Deals are listed by headline value. Where the deal has an agreement contract published at the SEC a link provides online access to the contract via the Current Agreements deals and alliances database.

Chapter 5 provides a review of the top 25 most active biopharma companies in collaborative R&D. Where the deal has an agreement contract published at the SEC a link provides online access to the contract via the Current Agreements deals and alliances database.

Chapter 6 provides a comprehensive review of collaborative R&D financials for deals announced since 2014, including headline value, upfront, milestone payments and royalty rates, providing both benchmark data and access to individual deal financials.

Chapter 7 provides a comprehensive and detailed review of collaborative R&D deals signed and announced since 2014 where a contract document is available. Each deal title links via Weblink to an online version of the actual contract document, providing easy access to each contract document on demand.

The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.

The report also includes numerous table and figures that illustrate the trends and activities in collaborative R&D dealmaking since 2014.

In addition, a comprehensive appendix is provided organized by company A-Z, stage of development, therapeutic target, technology type and deal type definitions. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

In conclusion, this report provides everything a prospective dealmaker needs to know about collaborative R&D partnering in the research, development and commercialization of technologies and products.

Key benefits

Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 provides the reader with the following key benefits:
  • In-depth understanding of collaborative R&D deal trends since 2014
  • Analysis of the structure of collaborative R&D agreements with numerous real life case studies
  • Comprehensive listing of over 5,000 collaborative R&D deals since 2014, together with deal terms, value and press release
  • Comprehensive access to actual collaborative R&D contracts entered into by the world’s life science companies
  • Analysis of key deal financials including headline value, upfront, milestone payments and royalty rates
  • Insight into the terms included in a collaborative R&D agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Report scope

Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 is intended to provide the reader with an in-depth understanding of the collaborative R&D trends and structure of deals entered into by leading life science companies worldwide.

Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 includes:
  • Trends in collaborative R&D dealmaking in the biopharma industry since 2014
  • Analysis of collaborative R&D deal structure
  • Case studies of real-life collaborative R&D deals
  • Comprehensive listing of over 5,000 collaborative R&D deals since 2014
  • Access to collaborative R&D contract documents
  • Key financial benchmarks for headline, upfront, milestone and royalty rates
  • The leading collaborative R&D deals by value since 2014
  • Most active collaborative R&D dealmakers since 2014
  • The leading collaborative R&D partnering resources
In Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 available deals and contracts are listed by:
  • Company A-Z
  • Headline value
  • Therapeutic area
  • Technology type
Each deal title links via Weblink to an online version of the actual deal record and where available, contract document, providing easy access to each contract document on demand.

The Global Collaborative R&D Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 report provides comprehensive access to available contract documents for licensing deals. Analyzing actual contract agreements allows assessment of the following:
  • What are the precise rights granted or optioned?
  • What is actually granted by the agreement to the partner company?
  • What exclusivity is granted?
  • What is the payment structure for the deal?
  • How do milestone align with clinical stage development phases?
  • How aresalesand payments audited?
  • What is the deal term?
  • How are the key terms of the agreement defined?
  • How are IPRs handled and owned?
  • Who is responsible for commercialization?
  • Who is responsible for development, supply, and manufacture?
  • How is confidentiality and publication managed?
  • How are disputes to be resolved?
  • Under what conditions can the deal be terminated?
  • What happens when there is a change of ownership?
  • What sublicensing and subcontracting provisions have been agreed?
  • Which boilerplate clauses does the company insist upon?
  • Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
  • Which jurisdiction does the company insist upon for agreement law?
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Executive Summary

Chapter 1 – Introduction

Chapter 2 – Trends in collaborative R&D dealmaking
2.1. Introduction
2.2. Definition of collaborative R&D partnering
2.3. Success factors for collaborative R&D deals
2.4. When collaborative R&D can be useful
2.5. Attributes of collaborative R&D deals
2.6. Trends in collaborative R&D deals since 2014
2.6.1. Collaborative R&D dealmaking by year, 2014 to 2020
2.6.2. Collaborative R&D dealmaking by phase of development, 2014 to 2020
2.6.3. Collaborative R&D dealmaking by industry sector, 2014 to 2020
2.6.4. Collaborative R&D dealmaking by therapy area, 2014 to 2020
2.6.5. Collaborative R&D dealmaking by technology type, 2014 to 2020
2.6.6. Collaborative R&D dealmaking by most active company, 2014 to 2020
2.7. The future of collaborative R&D deals

Chapter 3 – Overview of collaborative R&D deal structure
3.1. Introduction
3.2. Pure versus multi-component collaborative R&D deals
3.3. Pure collaborative R&D agreement structure
3.3.1. Example collaborative R&D agreements
3.3.1.a. Case study 1: Marinus Pharmaceuticals - NovaMedica
3.3.1.b. Case study 2: Idenix Pharmaceuticals – Janssen Pharmaceuticals
3.4. Collaborative R&D as part of a wider alliance agreement
3.4.1. Example collaborative R&D agreements and their licensing clauses
3.4.1.a. Case study 3: 4D Molecular Therapeutics – UniQure
3.4.1.b. Case study 4: Kyowa Hakko Kirin – Ultragenyx Pharmaceuticals
3.4.2. Example licensing option right clauses in collaborative R&D deals
3.4.2.a. Case study 5: Forest Laboratories - Trevena
3.4.2.b. Case study 6: Abbvie – Receptos

Chapter 4 – Leading collaborative R&D deals
4.1. Introduction
4.2. Top collaborative R&D deals by value

Chapter 5 – Top 25 most active collaborative R&D dealmakers
5.1. Introduction
5.2. Top 25 most active collaborative R&D dealmakers

Chapter 6 – Collaborative R&D deal term financials
6.1. Introduction
6.2. Collaborative R&D partnering headline values
6.3. Collaborative R&D deal upfront payments
6.4. Collaborative R&D deal milestone payments
6.5. Collaborative R&D royalty rates

Chapter 7 – Collaborative R&D contract directory 2014 - 2020
7.1. Introduction
7.2. Collaborative R&D deals with contracts 2014 to 2020

Appendices
Appendix 1 – Collaborative R&D dealmaking by companies A-Z
Appendix 2 – Collaborative R&D dealmaking by industry sector
Appendix 3 – Collaborative R&D dealmaking by stage of development
Appendix 4 – Collaborative R&D dealmaking by therapy area
Appendix 5 – Collaborative R&D dealmaking by technology type

TABLE OF FIGURES
Figure 1: Definition of collaborative R&D
Figure 2: Situations where collaborative R&D can prove useful
Figure 3: Key attributes of a collaborative R&D deal
Figure 4: Trends in Collaborative R&D deal announcements, 2014 to 2020
Figure 5: Collaborative R&D deals signed at each phase of development, 2014 to 2020
Figure 6: Collaborative R&D deals by industry sector, 2014 to 2020
Figure 7: Collaborative R&D deals by therapy area, 2014 to 2020
Figure 8: Collaborative R&D deals by technology type, 2014 to 2020
Figure 9: Top 25 most active collaborative R&D dealmakers, 2014 to 2020
Figure 10: Collaborative R&D agreements – what should a contract include?
Figure 11: Components of the collaborative R&D deal structure
Figure 12: Top collaborative deals by value 2014 to 2020
Figure 13: Most active collaborative R&D dealmakers 2014 to 2020
Figure 14: Collaborative R&D deals with a headline value
Figure 15: Collaborative R&D deals with an upfront value
Figure 16: Collaborative R&D deals with a milestone value
Figure 17: Collaborative R&D deals with a royalty rate value
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  • Exco InTouch
  • Exelixis
  • Exelon Generation Company
  • Exicure
  • Exonate
  • Exosome Diagnostics
  • Exosome Sciences
  • Exostar
  • Expansion Therapeutics
  • Expedeon
  • Expesicor
  • Exploragen
  • Expression Analysis
  • Expression Therapeutics
  • ExScientia
  • ExThera Medical
  • ExxPharma Therapeutics
  • EyeMedics
  • F-Star
  • Fabric Genomics
  • Facebook
  • Facio Therapies
  • Facit
  • Faes Farma
  • Fair Access Medicines
  • FairJourney Biologics
  • Fairview Health System
  • Faron Pharmaceuticals
  • Fast-Track Diagnostics
  • Fast Forward
  • FASTVet
  • Fate Therapeutics
  • FCH Group
  • FDA Center for Veterinary Medicine
  • FDNA
  • FedCentric Technologies
  • Federal Ministry of Education and Research (BMBF)
  • FEI
  • Feinstein Institute for Medical Research
  • Feist-Weiller Cancer Center
  • Feldan Therapeutics
  • Felicitex Therapeutics
  • Ferring Pharmaceuticals
  • Fertility SOURCE Companies
  • Fibriant
  • Fibrocell Science
  • Fibrocor Therapeutics
  • Fibrogen
  • Fidelta
  • Field
  • Fimbrion Therapeutics
  • Fina Biosolutions
  • Finch Therapeutics
  • Firefly Medical
  • FirstString Research
  • FISBA
  • Fitabase
  • FitBit
  • Five Prime Therapeutics
  • Flagship Biosciences
  • Flatiron Health
  • Flexpoint Sensor Systems
  • Flextronics
  • Flo Health
  • Florey Institute of Neuroscience and Mental Heath
  • Florida Atlantic University Research
  • Florida Hospital
  • Florida International University
  • Florida State University
  • FlowJo
  • Flow Pharma
  • FluidForm
  • Fluidigm
  • Fluofarma
  • Fluxion Biosciences
  • Flywheel
  • Foamix
  • FOB Synthesis
  • Focus Software of Alabama
  • Fogarty Institute for Innovation
  • Foley Hoag
  • Fondation Cancer
  • Fondatioun Kriibskrank Kanner
  • Fondazione Telethon
  • Food and Drug Administration (FDA)
  • Forbius
  • Forendo Pharma
  • Forge Therapeutics
  • FORMA Therapeutics
  • Formula Pharmaceuticals
Note: Product cover images may vary from those shown
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  • The publisher reports provide insight into the trends and terms of partnering deals in the global life sciences sector.
  • The publisher reports are updated every six months to ensure the user has access to the latest announcements and trends in the topic focus of the report.
  • The publisher analysts review the deal data to provide an overview and analysis of deal trends, including example deals and terms.
  • The publisher reports source deal data from our proprietary deals and alliances database. The database is updated daily by our analysts with new deals as they are announced globally by the company’s party to the deal.
  • The data in the deals and alliances database is obtained from secondary sources such as publicly available industry sources including press releases, company presentations, investor presentations, company SEC filings, other company filings, company websites, conference presentations. Sources are identified to allow for user verification.

The publisher provides comprehensive coverage of the following partnering or deal types:

  • Asset purchase
  • Assignment
  • Co-development
  • Co-market
  • Co-promotion
  • Collaborative R&D
  • Contract service
  • CRADA
  • Cross-licensing
  • Development
  • Distribution
  • Equity purchase
  • Evaluation
  • Grant
  • Joint venture
  • Licensing
  • Loan
  • Manufacturing
  • Marketing
  • Option
  • Promotion
  • Research
  • Royalty financing
  • Settlement
  • Spin out
  • Sub license
  • Supply
  • Termination
  • Warrant

Every deal record is fully categorized and includes the following data, where available:

  • Industry sector
  • Therapy areas
  • Technology type
  • Deal components
  • Financial terms
  • Stage of development
  • Exclusivity
  • Asset type
  • Geographic focus
  • Excluded geography
  • Company press release
  • SEC filing data including contract document

All financial amounts are converted to US$ using the exchange rate available on the date of deal announcement, enabling direct comparison of deal terms across international territories.

 

 

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