This new book provides cutting edge information for transplantation in lymphoma from a clinical perspective. With 26 chapters and over 50 international contributors this title offers a single reference for physicians on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies.
Section one provides an overview of transplantation in lymphoma, including the historical perspective, role of lymphoma working committees, current use of transplantation in children and adults, the variety of conditioning regimens for auto and allo–HSCT, pre–transplant evaluation, stem cell mobilizations, donor search for patients needing allo–HSCT, and management of long term complications after HSCT for lymphomas. Section two covers management of the lymphoid malignancies, focusing on standard of care transplant management, timing and preparing patients for transplantation, management of post– transplant relapses and most importantly discussion on novel therapies and their integration in transplantation for lymphomas.
The appendices provide a quick reference checklist on follow–up after autologous and allogenic stem cell transplantation in lymphoma.
- Provides practical management guidance on how to integrate, transplantation and novel therapies in patients with lymphoid malignancies
- Covers an overview of transplantation in lymphoma, and management of the lymphoid malignancies
- Discusses organizational aspects of transplant patients and managing a transplant program
- Appendices provide handy quick–reference information on follow–up after autologous and allogenic stem cell transplantation in lymphoma
This title is of use for transplant clinicians, oncologists, and haematologists.
List of contributors vii
Section 1: Transplantation in lymphomas
1 Lymphoma and transplantation: historical perspective 5Andrew R. Rezvani
2 Lymphoma: working committee and data reporting after transplantation in lymphoma 13Wael Saber, Mehdi Hamadani, Shahrukh Hashmiand Parameswaran Hari
3 Use of transplantation in lymphoma: adults 23Parastoo Bahrami Dahi, Gabriela Soriano Hobbsand Miguel ]Angel Perales
4 Hematopoietic stem cell transplantation for lymphoma in children, adolescents, and young adults 31Nader Kim El ]Mallawany and Mitchell S. Cairo
5 Preparative regimens for lymphoma: autologous hematopoietic stem cell transplantation 45Taiga Nishihori, Karma Z. Salem, Ernesto Ayalaand Mohamed A. Kharfan ]Dabaja
6 Preparative regimens for lymphoma: allogeneic hematopoietic stem cell transplantation 57Mohamed A. Kharfan ]Dabaja, Najla El ]Jurdi,Mehdi Hamadani and Ernesto Ayala
7 Pretransplantation evaluation, comorbidities, and nondisease ]related eligibility criteria for transplantation in lymphoma, 69Melissa Logue
8 Stem cell mobilization in lymphoma patients 75Tarah Ballinger, Bipin N. Savaniand Mohamad Mohty
9 Allogeneic hematopoietic stem cell transplantation for lymphoma: stem cell source, donor, and HLA matching 85Michael Green and Mitchell Horwitz
10 Management of early and late toxicities of autologous hematopoietic stem cell transplantation 93Sai Ravi Pingali and Yago Nieto
11 Long ]term follow ]up of lymphoma patients after allogeneic hematopoietic cell transplantation 103Shylaja Mani and Navneet S. Majhail
12 First 100 days of the autologous hematopoietic stem cell transplantation process in lymphoma 109Angela Moreschi Woods
13 First 100 days of the allogeneic hematopoietic stem cell transplantation process in lymphoma 113Angela Moreschi Woods
Section 2: Management
14 Stem cell transplantation in follicular lymphoma,119Satyajit Kosuri and Koen Van Besien
15 Chronic lymphocytic leukemia/small lymphocytic lymphoma 133Salyka Sengsayadeth and Wichai Chinratanalab
16 Diffuse large B ]cell lymphoma 145Lauren Veltri, Bipin N. Savani, Mohamed A. Kharfan ]Dabaja, Mehdi Hamadaniand Abraham S. Kanate
17 Mantle cell lymphoma 161Sascha Dietrich and Peter Dreger
18 Hodgkin lymphoma 173Eva Domingo ]Domenech and Anna Sureda
19 Peripheral T ]cell lymphomas 187Giulia Perrone, Chiara De Philippis, Lucia Farinaand Paolo Corradini
20 Transplantation in Burkitt and lymphoblastic lymphoma 201Gregory A. Hale
21 Transplantation in adult T ]cell leukemia/lymphoma 209Ali Bazarbachi and Olivier Hermine
22 Hematopoietic cell transplantation for HIV ]related lymphomas 217Joseph C. Alvarnas
23 Stem cell transplantation for mycosis fungoides/Sézary syndrome 233Eric D. Jacobsen
24 Role of transplantation in lymphoplasmacytic lymphoma 241Silvia Montoto and Charalampia Kyriakou
25 Transplantation outcome in primary mediastinal large B ]cell lymphoma 247Amanda F. Cashen
26 Management of post ]transplant lymphoproliferative disorders 253Jan Styczynski and Per Ljungman
Appendix I Follow ]up calendar after autologous stem cell transplantation in lymphoma 261Angela Moreschi Woods
Appendix II Follow ]up calendar after allogeneic stem cell transplantation in lymphoma 263Angela Moreschi Woods
exponential information growth this book is surprisingly current, with the latest references. It has an ambitious scope, setting out to cover all aspects of transplantation in lymphoma and managing to meet that expectation.
Chapters are laid out in logical sequence divided into 2 sections. Section 1 is particularly interesting and has
chapters on the historical perspective of transplantation for lymphoma, transplant data collection and reporting, and analytical methods. The remainder of section 1 describes the general principles of transplantation in lymphomas, addressing issues such as mobilization, preparative regimens, and management of the early, late, and long–term issues arising after transplantation. Some chapters include transplantation for lymphoma in children, adults, and young adolescents; pretransplant evaluation; preparative regimens for autologous and allogeneic transplants; stem cell mobilization and stem cell source; post–transplant follow–up for autologous
and allogeneic transplant, and a novel chapter, First 100 Days of the Autologous Hematopoietic Stem Cell Transplantation Process in Lymphoma. The chapters in section 1 are broadly applicable and would prove invaluable to trainees pursuing fellowships in hematopoietic cell transplantation.
Section 2 is laid out as a chapter by chapter discussion of various lymphoma histologies and the applicability of hematopoietic cell transplantation in each. One can return to some of these chapters again and again because all common and most rare lymphoma subtypes (including HIV–associated lymphoma) are discussed in excellent detail. We found each one of these chapters to be remarkably up to date. In a field such ashematopoietic cell transplantation,where there is considerable ambiguity and few randomized studies, the authors and editors have maintained a neutral and unbiased tone,discussing the available data andguidelines exhaustively.
Very few similar textbooks focus on transplantation in a disease group.Clinical Guide to Transplantation in Lymphoma is concise enough, practical, and clinically oriented to be considered a practical manual but at the same time manages to be comprehensive. Some unique features in this book are the numerous excellent graphs and tables and the discussion of case studies and clinical guidelines (United States and European) wherever applicable. We found very few typographic errors. For future editions we recommend at least 1 chapter devoted to the emerging field of cellular immunotherapy.
The editors and the contributors need to be congratulated for an encyclopedic work that still manages to be a ready reference guide. This book will be used extensively and should be in the library of every transplanter.We hope it runs into many future editions and becomes the authoritative textbook for transplantation in lymphoma. (
Yogesh Jethava, Parameswaran Hari, University of Arkansas for Medical Science,Biology of Blood and Marrow Transplantation, Nov 2015)