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Vaccines and Autoimmunity

  • ID: 3148794
  • Book
  • 384 Pages
  • John Wiley and Sons Ltd
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In light of the discovery of autoimmune/inflammatory syndrome induced by adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants specifically aluminum in different vaccines and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.

Vaccines and Autoimmunity is divided into three sections. The first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant–induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick building syndrome (SBS), safe vaccines, toll–like receptors (TLRs), TLRs in vaccines, pesticides as adjuvants, oil as an adjuvant, mercury, aluminum and autoimmunity. The second section reviews the literature on vaccines that have induced autoimmune conditions, such as MMR and HBV. The final section covers diseases in which vaccines are known to be the solicitor for instance, systemic lupus erythematosus and whether they can be induced by vaccines for MMR, HBV, HCV, and others.

Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Summary of how adjuvants can induce diverse autoimmune clinical manifestations in genetically prone subjects

Review of the literature on all vaccines that have been found to induce autoimmune conditions

Full discussion of autoimmune diseases in which vaccines are known to be the solicitor

Excellent source for future pathogenic and epidemiological studies

Edited and authored by leaders in the field

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Contributors, ix

Introduction 1Yehuda Shoenfeld, Nancy Agmon–Levin and Lucija Tomljenovic


1 Role of Adjuvants in Infection and Autoimmunity 11Eitan Israeli, Miri Blank, and Yehuda Shoenfeld

2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect 25Quan M. Nhu and Noel R. Rose

3 Experimental Models of Adjuvants 35Nicola Bassi, Mariele Gatto, Anna Ghirardello, and Andrea Doria

4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines 43Lucija Tomljenovic and Christopher A. Shaw

5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept 57Vera Stejskal

6 Genetics and Vaccinology 65John Castiblanco and Juan–Manuel Anaya

7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) 79Yair Levy and Rotem Baytner–Zamir

8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search 87Elisabetta Borella, Eitan Israeli, and Yehuda Shoenfeld

9 Autoantibodies Induced by Vaccine 93Nata a Toplak and Tadej Av¢§cin

10 The ASIA Syndrome Registry 103Ignasi Rodriguez–Pintó and Yehuda Shoenfeld

11 Vaccination in Autoimmune Diseases 107Carla Gonçalves, Schahin Saad, Clóvis A. Silva, and Eloisa Bonfá

12 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases 113Abdulla Watad, Alessandra Soriano, and Yehuda Shoenfeld


13 Measles, Mumps, and Rubella Vaccine: A Triad to Autoimmunity 129Carlo Perricone, Guido Valesini, and Yehuda Shoenfeld

14 Yellow Fever Vaccine and Autoimmunity 135Roger A. Levy and Rodrigo Poubel V. Rezende

15 Antiphospholipid Syndrome and Vaccines 141Miri Blank and Paola Cruz–Tapias

16 Hepatitis B Vaccination and Autoimmunity 147Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, and Dimitrios P. Bogdanos

17 Adverse Reactions to Human Papillomavirus Vaccines 163Lucija Tomljenovic and Christopher A. Shaw

18 Influenza Vaccine and Autoimmune Diseases 175Luis J. Jara, Gabriela Medina, Pilar Cruz Dominguez, Olga Vera–Lastra, Miguel A. Saavedra, Mónica Vázquez del Mercado, and Minoru Satoh

19 Vaccines and Autoimmunity: Meningococcal Vaccines 185Giovanna Passaro, Alessandra Soriano, and Raffaele Manna

20 Pneumococcal Vaccines and Autoimmune Phenomena 191Elisabetta Borella, Nancy Agmon–Levin, Andrea Doria, and Yehuda Shoenfeld

21 BCG and Autoimmunity 197Luigi Bernini, Carlo Umberto Manzini, and Clodoveo Ferri


22 Systemic Lupus Erythematosus Induced by Vaccines 209Nurit Katz–Agranov and Gisele Zandman–Goddard

23 Vasculitides 223Alessandra Soriano, Rotem Inbar, Giovanna Passaro, and Raffaele Manna

24 Vaccinations in Rheumatoid Arthritis 233Eitan Giat and Merav Lidar

25 Undifferentiated Connective–Tissue Diseases 247Maria Martinelli, Carlo Perricone, and Yehuda Shoenfeld

26 Vaccines, Infections, and Alopecia Areata 255Yaron Zafrir, Sharon Baum, Nancy Agmon–Levin, and Yehuda Shoenfeld

27 Aluminum Particle Biopersistence, Systemic Transport, and Long–Term Safety: Macrophagic Myofasciitis and Beyond 261Romain K. Gherardi, Josette Cadusseau, and François–Jérôme Authier

28 Immune Thrombocytopenic Purpura: Between Infections and Vaccinations 271Carlo Perricone, Maurizio Rinaldi, Roberto Perricone, and Yehuda Shoenfeld

29 Vaccinations and Type 1 Diabetes 283Alessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ele Ferrannini, and Poupak Fallahi

30 Narcolepsy and H1N1 vaccine 291María–Teresa Arango, Shaye Kivity, Nancy Agmon–Levin, Gili Givaty, Joab Chapman, and Yehuda Shoenfeld

31 Non–nutritional Environmental Factors Associated with Celiac Disease: Infections and Vaccinations, 301Aaron Lerner

32 Polymyalgia Rheumatica 307Alessandra Soriano and Raffaele Manna

33 Acute Disseminated Encephalomyelitis: Idiopathic, Post–infectious, and Post–vaccination 311Dimitrios Karussis and Panayiota Petrou

34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand? 331Jacob N. Ablin and Dan Buskila

35 Bullous Dermatoses, Infectious Agents, and Vaccines 337Yaron Zafrir, Nancy Agmon–Levin, and Sharon Baum

36 Infections, Vaccinations, and Chronic Fatigue Syndrome 345Hussein Mahagna, Naim Mahroum, and Howard Amital

37 Myositis and Vaccines 349Ignasi Rodriguez–Pintó and Yehuda Shoenfeld

Index 359

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Yehuda Shoenfeld
Nancy Agmon–Levin
Lucija Tomljenovic
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