In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals.
Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others.
Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.Table of Contents
Contributors ix
Introduction 1
Yehuda Shoenfeld, Nancy Agmon-Levin and Lucija Tomljenovic
Part I: Mosaic of Autoimmunity
1 Role of Adjuvants in Infection and Autoimmunity 11
Eitan Israeli, Miri Blank, and Yehuda Shoenfeld
2 Infections as Adjuvants for Autoimmunity: The Adjuvant Effect 25
Quan M. Nhu and Noel R. Rose
3 Experimental Models of Adjuvants 35
Nicola Bassi, Mariele Gatto, Anna Ghirardello, and Andrea Doria
4 Answers to Common Misconceptions Regarding the Toxicity of Aluminum Adjuvants in Vaccines 43
Lucija Tomljenovic and Christopher A. Shaw
5 Allergy and Autoimmunity Caused by Metals: A Unifying Concept 57
Vera Stejskal
6 Genetics and Vaccinology 65
John Castiblanco and Juan-Manuel Anaya
7 Silicone and Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) 79
Yair Levy and Rotem Baytner-Zamir
8 Silicone Breast Implants and Autoimmune/Inflammatory Syndrome induced by Adjuvants (ASIA): A Literature Search 87
Elisabetta Borella, Eitan Israeli, and Yehuda Shoenfeld
9 Autoantibodies Induced by Vaccine 93
Nataša Toplak and Tadej Av¢§cin
10 The ASIA Syndrome Registry 103
Ignasi Rodriguez-Pinto and Yehuda Shoenfeld
11 Vaccination in Autoimmune Diseases 107
Carla Goncalves, Schahin Saad, Clovis A. Silva, and Eloisa Bonfa
12 Vaccination in Patients with Autoimmune Inflammatory Rheumatic Diseases 113
Abdulla Watad, Alessandra Soriano, and Yehuda Shoenfeld
Part II: Studies on Autoimmune Conditions Induced by Vaccination
13 Measles, Mumps, and Rubella Vaccine: A Triad to Autoimmunity 129
Carlo Perricone, Guido Valesini, and Yehuda Shoenfeld
14 Yellow Fever Vaccine and Autoimmunity 135
Roger A. Levy and Rodrigo Poubel V. Rezende
15 Antiphospholipid Syndrome and Vaccines 141
Miri Blank and Paola Cruz-Tapias
16 Hepatitis B Vaccination and Autoimmunity 147
Daniel S. Smyk, Lazaros I. Sakkas, Yehuda Shoenfeld, and Dimitrios P. Bogdanos
17 Adverse Reactions to Human Papillomavirus Vaccines 163
Lucija Tomljenovic and Christopher A. Shaw
18 Influenza Vaccine and Autoimmune Diseases 175
Luis J. Jara, Gabriela Medina, Pilar Cruz Dominguez, Olga Vera-Lastra, Miguel A. Saavedra, Monica Vazquez del Mercado, and Minoru Satoh
19 Vaccines and Autoimmunity: Meningococcal Vaccines 185
Giovanna Passaro, Alessandra Soriano, and Raffaele Manna
20 Pneumococcal Vaccines and Autoimmune Phenomena 191
Elisabetta Borella, Nancy Agmon-Levin, Andrea Doria, and Yehuda Shoenfeld
21 BCG and Autoimmunity 197
Luigi Bernini, Carlo Umberto Manzini, and Clodoveo Ferri
Part III: Autoimmune Diseases Solicited by Vaccination
22 Systemic Lupus Erythematosus Induced by Vaccines 209
Nurit Katz-Agranov and Gisele Zandman-Goddard
23 Vasculitides 223
Alessandra Soriano, Rotem Inbar, Giovanna Passaro, and Raffaele Manna
24 Vaccinations in Rheumatoid Arthritis 233
Eitan Giat and Merav Lidar
25 Undifferentiated Connective-Tissue Diseases 247
Maria Martinelli, Carlo Perricone, and Yehuda Shoenfeld
26 Vaccines, Infections, and Alopecia Areata 255
Yaron Zafrir, Sharon Baum, Nancy Agmon-Levin, and Yehuda Shoenfeld
27 Aluminum Particle Biopersistence, Systemic Transport, and Long-Term Safety: Macrophagic Myofasciitis and Beyond 261
Romain K. Gherardi, Josette Cadusseau, and Francois-Jerome Authier
28 Immune Thrombocytopenic Purpura: Between Infections and Vaccinations 271
Carlo Perricone, Maurizio Rinaldi, Roberto Perricone, and Yehuda Shoenfeld
29 Vaccinations and Type 1 Diabetes 283
Alessandro Antonelli, Silvia Martina Ferrari, Andrea Di Domenicantonio, Ele Ferrannini, and Poupak Fallahi
30 Narcolepsy and H1N1 vaccine 291
María -Teresa Arango, Shaye Kivity, Nancy Agmon-Levin, Gili Givaty, Joab Chapman, and Yehuda Shoenfeld
31 Non-nutritional Environmental Factors Associated with Celiac Disease: Infections and Vaccinations 301
Aaron Lerner
32 Polymyalgia Rheumatica 307
Alessandra Soriano and Raffaele Manna
33 Acute Disseminated Encephalomyelitis: Idiopathic, Post-infectious, and Post-vaccination 311
Dimitrios Karussis and Panayiota Petrou
34 Fibromyalgia, Chronic Fatigue, Functional Disorders, and Vaccination: Where Do We Stand? 331
Jacob N. Ablin and Dan Buskila
35 Bullous Dermatoses, Infectious Agents, and Vaccines 337
Yaron Zafrir, Nancy Agmon-Levin, and Sharon Baum
36 Infections, Vaccinations, and Chronic Fatigue Syndrome 345
Hussein Mahagna, Naim Mahroum, and Howard Amital
37 Myositis and Vaccines 349
Ignasi Rodriguez-Pinto and Yehuda Shoenfeld
Index 359
