Epigenetic Technological Applications

Table of Contents

Preface
1. Introduction of the Epigenetic Technologies
2. Technologies for the Measurement and Mapping of Genomic 5-methylcytosine and 5-hydroxymethylcytosine
3. Technologies to Map DNA 5hC and 5fC and 5caC
4. Application of Mass Spectrometry in Translational Epigenetics
5. Techniques Analyzing Chromatin Modifications at Specific Single Loci
6.  Comprehensive Analysis of Mammalian Linker-histone Variants and Their Mutants
7. Crystallography-based Mechanistic Insights into Epigenetic Regulation
8. Chemical and Genetic Approaches to Study Histone Modifications
9. Peptide Microarrays for Profiling of Epigenetic Targets
10. Current Methods for Methylome Profiling
11. Bioinformatics and Biostatistics for Mining Epigenetic Disease Markers and Targets
12. Computational Modeling to Elucidate Molecular Mechanisms of Epigenetic Memory
13. DNA Methyltransferase Inhibitors for Cancer Therapy
14. Histone Acetyltransferases: Enzymes, Assays, and Inhibitors
15. In Vitro Histone Deacetylase Activity Screening: Making a Case for Better Assays
16. Enzymatic Assays of Histone Methyltransferase Enzymes
17. Histone Methyltransferase Inhibitors for Cancer Therapy
18. Discovery of Histone Demethylase Inhibitors
19. Fluorescent Technologies in Studying Dynamics of Histone Modification
20. Animal Model Study of Epigenetic Inhibitors

Authors

Ya-Ping George Zheng Associate Professor, Department of Pharmaceutical and Biomedical Sciences, University of Georgia.