Osteoimmunology. Interactions of the Immune and Skeletal Systems. Edition No. 2

Table of Contents

1. Overview

2. Origins of the Osteoclast

3. Trafficking of Osteoclast Precursors

4. Osteoclast Biology: Regulation of Formation and Function

5. Osteoblasts and the Immune system

6. Osteocyte Biology

7. Bone Cells and the Hematopoietic Niche

8. The Function of RANKL Beyond the Osteoclast

9. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

10. Coupling Between Immune and Bone Cells

11. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk

12. The Role of Sex Steroiods in the Interactions of the Immune System with Bone

13. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis

14. Osteoarthritis and the Immune System

15. Inflammatory Bowel Disease and Bone

16. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

17. The Role of the Immune System in Fracture Healing

18. The Role of the Immune System in the Effects of Cancer on Bone

19. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

20. The Role of the Immune System in the Interactions of Fat and Bone

Authors

Joseph Lorenzo University of Connecticut Health Center, Farmington, CT, USA. Dr. Lorenzo is Professor of medicine in the Division of Endocrinology and Metabolism and Director of Bone Biology Research at the University of Connecticut Health Center. He is a nationally renowned expert on bone remodeling and its effect on bone health. Mark Horowitz Yale University School of Medicine, New Haven, CT, USA. Dr. Horowitz is Professor of Orthopaedics and Rehabilitation at the Yale University School of Medicine. His research interests include the interactions between the skeletal, immune, and hematopoietic systems as they relate to normal and pathologic bone remodeling. Yongwon Choi University of Pennsylvania, Philadelphia, PA, USA. Dr. Choi is Professor of Pathology and Laboratory Medicine, University of Pennsylvania; Investigator, The Leonard and Marilyn Abramson Family Cancer Research Institute, Philadelphia, PA. Hiroshi Takayanagi Tokyo Medical and Dental University, Tokyo, Japan. Dr. Takayanagi is Professor in the Department of Cell Signaling, Tokyo Medical and Dental University. His group studies the mechanism of bone destruction in rheumatoid arthritis, which focuses on the regulation of osteoclasts by T cells. This interdisciplinary field, osteoimmunology, covers various research on shared mechanisms and interactions between immune and bone systems. Georg Schett University of Erlangen-Nuremberg, Germany.