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Genomic and Precision Medicine. Infectious and Inflammatory Disease. Edition No. 3

  • Book

  • August 2019
  • Elsevier Science and Technology
  • ID: 3612335

Genomic and Precision Medicine: Infectious and Inflammatory Disease, Third Edition, provides current clinical solutions on the application of genome discovery on a broad spectrum of disease categories in IMD - including asthma, obesity and multiple sclerosis. Each chapter is organized to cover the application of genomics and personalized medicine tools and technologies, along with information on a) Risk Assessment and Susceptibility, b) Diagnosis and Prognosis, c) Pharmacogenomics and Precision Therapeutics, and d) Emerging and Future Opportunities in the field.

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Table of Contents

1. Overview: Genome wide approaches to Inflammatory and Metabolic disease
2. Application of Human Genome Information to Clinical Practice
3. Translating genome information into clinical practice and human health
4. Big Data and Translational Bioinformatics Genomic and Personalized Medicine
5. Health Risk Assessment and Family History
6. Clinical Decision Support
7. Overview of Policy, Ethical and Social Considerations
8. Autoimmune Disorders
9. Rheumatoid Arthritis
10. Multiple Sclerosis
11. Inflammatory Bowel Disease
12. Asthma
13. Chronic Obstructive Pulmonary Disease
14. Interstitial Lung Disease
15. Peptic Ulcer Disease
16. Cirrhosis
17. Systemic Sclerosis
18. Lupus
19. Osteoarthritis
20. Diabetes Genomics
21. The Metabolic Syndrome
22. Approaching Obesity
23. Case Studies

Authors

Geoffrey S. Ginsburg Chief Medical and Scientific Officer, All of Us Research Program, National Institutes of Health, Bethesda, Maryland, USA. Dr. Ginsburg is the founding Director of the Center for Applied Genomics & Precision Medicine in the Duke Institute for Genome Sciences & Policy. He is also Professor of Medicine and of Pathology at Duke University Medical Center, Professor of Biomedical Engineering at Duke Pratt School of Engineering, and Co-Director of the Duke Translational Medicine Institute. Huntington F Willard Chief Scientific Officer, Genome Medical, Inc., South San Francisco, CA, USA. Huntington Willard is on the faculty of the Department of Human Genetics at the University of Chicago. Prior to this appointment, Willard was the President and Director of the Marine Biological Laboratory and Professor of Human Genetics at the University of Chicago. He was previously on the faculty at Duke University, where he was founding director of the university-wide Duke Institute for Genome Sciences & Policy from 2003 to 2014, the Nanaline H. Duke Professor of Genome Sciences, and the Arts & Sciences Professor of Biology & Genome Sciences. Christopher W. Woods Professor of Medicine and Global Health, Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine; Chief, Infectious Disease Division, Durham VA Health Care System, USA. Ephraim L. Tsalik Duke Center for Applied Genomics & Precision Medicine, Duke University School of Medicine; Emergency Department Service, Durham VA Health Care System, USA.. Dr. Tsalik obtained his MD and PhD at Columbia University before coming to Duke for his clinical training in Internal Medicine followed by fellowship in Infectious Diseases. He is currently an Associate Professor of Medicine, Associate Professor of Molecular Genetics and Microbiology, and is a Physician in the Emergency Department at the Durham VA Health Care System. He is also Associate Director of Diagnostics for the Antibacterial Resistance Leadership Group. His research focuses on the host response to infection with a particular emphasis on translation to diagnostic tests.