Conn's Translational Neuroscience

  • ID: 3627086
  • Book
  • 776 Pages
  • Elsevier Science and Technology
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Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes.

This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis.

In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance.

  • Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance
  • Features contributions from leading global basic and clinical investigators in the field
  • Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes
  • Relates and translates the current science to the understanding of neurological disorders and their treatment
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Chapter 1. Cytology of the Central Nervous System

Chapter 2. Ion Channels

Chapter 2.1. Translational Correlation: Temporal Lobe Epilepsy and Hippocampal Sclerosis

Chapter 3. Neurotransmitters and Neurotransmission in the Developing and Adult Nervous System

Chapter 3.1. Translational Correlation: Myasthenia Gravis and Other Neuromuscular Junction Disorders

Chapter 4. Synaptic Development

Chapter 5. The Peripheral and Central Nervous System

Chapter 5.1. Translational Correlation: Peripheral Neuropathy

Chapter 5.2. Translational Correlation: Guillain-Barré Syndrome

Chapter 6. The Blood-Brain Barrier: A Restricted Gateway to the Brain

Chapter 7. Autoregulation of Cerebral Blood Flow

Chapter 7.1. Translational Correlation: Stroke

Chapter 7.2. Translational Correlation: Migraine

Chapter 8. The Vestibular System

Chapter 8.1. Translational Correlation: Vertigo

Chapter 9. The Cerebellum

Chapter 9.1. Translational Correlation: Disorders of the Cerebellum

Chapter 10. The Basal Ganglia

Chapter 10.1. Translational Correlation: Disorders of the Basal Ganglia

Chapter 11. Choroid Plexus-Cerebrospinal Fluid Transport Dynamics: Support of Brain Health and a Role in Neurotherapeutics

Chapter 12. The Cerebral Cortex

Chapter 13. The Thalamus

Chapter 14. Cranial Nerves and Brainstem

Chapter 14.1. Translational Correlation: Bell's Palsy

Chapter 15. Hypothalamic-Pituitary Regulation

Chapter 16. Neuroendocrinimmunology: A Primer

Chapter 16.1. Translational Correlation: Clinical Neuroimmunology

Chapter 16.2. Translational Correlation: Multiple Sclerosis

Chapter 17. The Olfactory System

Chapter 18. Intranasal Trigeminal Chemoreception

Chapter 19. Vision

Chapter 20. Oculomotor Systems and Control

Chapter 21. A Modern Clinicopathological Approach to Traumatic Brain Injury

Chapter 21.1. Translational Correlation: Disorders of the Spinal Cord

Chapter 21.2. Translational Correlation: Abnormalities of the CSF System

Chapter 22. Posttraumatic Stress Disorder

Chapter 23. Somatosensation and Pain

Chapter 23.1. Translational Correlation: Trigeminal Neuralgia

Chapter 24. Neurogenesis as a Factor in the Functional Plasticity of the Nervous System

Chapter 25. Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems

Chapter 25.1. Translational Correlation: Sarcopenia

Chapter 26. Audition

Chapter 27. Body Clocks in Health and Disease

Chapter 27.1. Translational Correlation: Sleep Disorders

Chapter 28. The Experience of Consciousness

Chapter 29. The Emotional Brain

Chapter 29.1. Translational Correlation: Limbic Encephalitis

Chapter 30. Stress, Mood, and Pathways to Depression

Chapter 31. Language Processing, Development and Evolution

Chapter 32. Memory

Chapter 32.1. Translational Correlation: Alzheimer's Disease

Chapter 33. Neurobiology of Drugs of Abuse

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Conn, P. Michael
Dr. P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center. He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone in the pituitary and therapeutic approaches that restore misfolded proteins to function. His lab is credited with the first demonstrations of GPCR internalization and oligomerization. His work has led to drugs that have benefitted humans and animals. Most recently, his lab identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications and written or edited over 225 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the Miguel Aleman Prize of Mexico and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation.
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