Nanobiomaterials in Antimicrobial Therapy presents novel antimicrobial approaches that enable nanotechnology to be used effectively in the treatment of infections. This field has gained a large amount of interest over the last decade, in response to the high resistance of pathogens to antibiotics.
Leading researchers from around the world discuss the synthesis routes of nanobiomaterials, characterization, and their applications as antimicrobial agents. The books covers various aspects: mechanisms of toxicity for inorganic nanoparticles against bacteria; the development of excellent carriers for the transport of a high variety of antimicrobials; the use of nanomaterials to facilitate both diagnosis and therapeutic approaches against infectious agents; strategies to control biofilms based on enzymes, biosurfactants, or magnetotactic bacteria; bacterial adhesion onto polymeric surfaces and novel materials; and antimicrobial photodynamic inactivation.
This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians.
- A methodical approach to this highly relevant subject for researchers, practitioners and students working in biomedical, biotechnological and engineering fields
- A valuable guide to recent scientific progress and the latest application methods
- Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine and nanobiology
Introduction to Nanobiomaterials in Antimicrobial Therapies 1. Antimicrobial photoinactivation with functionalized fullerenes 2. Toxicity of inorganic nanoparticles against prokaryotic cells 3. Antimicrobial magnetosomes for topical antimicrobial therapy 4. Synthesis, characterization, and applications of nanobiomaterials for antimicrobial therapy 5. Antimicrobial micro/nanostructured functional polymer surfaces 6. Differential biological activities of silver nanoparticles against Gram-negative and Gram-positive bacteria: a novel approach for antimicrobial therapy 7. Enhancement of pathogen detection and therapy with laser-activated, functionalized gold nanoparticles 8. Antimicrobial properties of nanobiomaterials and the mechanism 9. Scopes of green synthesized metal and metal oxide nanomaterials in antimicrobial therapy 10. Antifungal nanomaterials: synthesis, properties, and applications 11. Strategies based on microbial enzymes and surface-active compounds entrapped in liposomes for bacterial biofilm control 12. Interaction of nanoceria with microorganisms 13. PLA and PLGA nanoarchitectonics for improving anti-infective drugs efficiency 14. Nanoparticles: boon to mankind and bane to pathogens 15. The citation classics in antimicrobial nanobiomaterials
Dr. Alexandru Mihai Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biostructures, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, Biomaterials and Tissue Engineering Bulletin, and Journal of Food Bioengineering and Nanoprocessing. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 8 co-authored books and 21 edited books.
He has developed two new research directions related to bio-applications of metal oxide nanoparticles: (i) functional metal oxide nanostructures to improve the delivery of antimicrobials in active form with a high efficiency against Gram-positive and Gram-negative bacteria; and (ii) smart metal oxide nanostructures, functionalized with different fatty acids, essential oils or in combination with organic polymers, to inhibit bacterial colonization of different medical or industrial surfaces.
Dr Alexandru Mihai Grumezescu is also Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano- and biostructures, and he is the Editor-in-Chief of four journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, Biomaterials and Tissue Engineering Bulletin, and Journal of Food Bioengineering and Nanoprocessing. He also serves as editor or guest editor for several notable journals. Dr Grumezescu has published 160 peer-reviewed papers, 20 book chapters, 9 coauthored books, and 21 edited books. Other details are available at http://grumezescu.com/.