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  • ID: 3680212
  • Book
  • 344 Pages
  • John Wiley and Sons Ltd
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Given the aging population of the developed world, and the increasing survival rates from traditional diseases such as cancer, the numbers of patients suffering from neurodegenerative diseases is increasing. Not only do these diseases inflict pain and emotional toil on their sufferers and their families, they also require years of costly health care

Many of the neurodegenerative diseases have been considered within more traditional domains of neurology, such as movement disorders or behavioral neurology. However, there is increasing recognition that this symptom–based classification does not correspond to underlying pathologies for which evidence of similarity is emerging.

This book draws together clinical and research information on neurodegenerative diseases, beginning with the common elements before treating each disease individually using a standard template. Uniquely diseases will be grouped by anatomical regions of degeneration – which are largely but not exclusively related to symptomatic considerations.

General chapter topics cover what can be considered normal aging versus neurodegenerative diseases, and discuss the initial indications of neurodegeneration progression of symptoms. Diagnostic guidelines include how to apply cognitive examinations, movement examinations, and lab and imaging investigations to reach a diagnosis – an often very complex process in neurodegenerative disease. Also discussed are patient health care issues, and the effect on carers and families, and palliative and end–of–life care.

Key Features

  • Presents a clinically oriented guide to the diseases caused by neurodegeneration
  • Includes templated chapters with helpful pedagogy
  • Groups diseases by anatomical regions of degeneration, including common disorders such as Parkinson′s disease, Alzheimer′s disease, amyotrophic lateral sclerosis/motor neuron disease, and multiple sclerosis as well as less common diseases
  • Offers expert advice from globally leading authorities on the subject

This book will be of use to neurologists, and will be of interest to neuropsychiatrists who deal with psychiatric aspects of neurological disease. It will also be relevant to neuroscientists who need to know more of the clinical aspects of the conditions they are working on.

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List of Contributors, vi

Preface, ix

Dedication, x

1 Pathology of Brain Aging, 1
Janna H. Neltner and Peter T. Nelson

2 Protein Aggregation and Neurodegeneration: Tauopathies and Synucleinopathies, 12
Michel Goedert

3 Prion Degeneration, 25
James A. Mastrianni

4 Excitotoxicity, 37
Mark P. Mattson

5 Etiology and Pathogenesis of Parkinson Disease, 46
Ruth–Mary deSouza and Anthony H.V. Schapira

6 Parkinson Disease: Treatment Options – Surgical Therapy, 53
Travis S. Tierney and Andres M. Lozano

7 Multiple System Atrophy: Clinical, Genetics, and Neuropathology, 58
Lucia V. Schottlaender, Anna Sailer, Zeshan Ahmed, Dennis W. Dickson, Henry Houlden, and Owen A. Ross

8 Progressive Supranuclear Palsy, 72
Huw R. Morris

9 Dementia with Lewy Bodies, 83
Rodolfo Savica and David S. Knopman

10 Corticobasal Degeneration, 93
Keith A. Josephs, Jr.

11 Alzheimer’s Disease, 102
Qurat ul Ain Khan and Neill R. Graff–Radford

12 Frontotemporal Dementia, 115
Christian W. Wider, Barbara Jasinska–Myga, Takuya Konno, and Zbigniew K. Wszolek

13 Prion Diseases and Other Rapidly Progressive Dementias, 126
Eric Eggenberger and Daniel L. Murman

14 Amyotrophic Lateral Sclerosis and Primary Lateral Sclerosis, 137
Kevin B. Boylan, Mark A. Ross, and Eric J. Sorenson

15 Hereditary Spastic Paraplegia, 161
Pawel P. Liberski and Craig Blackstone

16 Spinal Muscular Atrophy, 179
Joseph R. Wooley, Melissa E. Crowder, Noah J. Pyles, and Charlotte J. Sumner

17 Spinal and Bulbar Muscular Atrophy (Kennedy Disease), 202
Erich Peter Bosch

18 Optic Neuropathies, 211
Desmond Kidd

19 Peripheral Nerve Neuropathies Including Charcot–Marie–Tooth Disease, 218
Amelie Pandraud and Henry Houlden

20 Axonal Loss and Neurodegeneration in Multiple Sclerosis, 238
Ranjan Dutta, Jacqueline Chen, Nobuhiko Ohno, Daniel Ontaneda, and Bruce D. Trapp

21 Huntington’s Disease and Other Choreas, 248
Salman Haider, Edward Wild, and Sarah J. Tabrizi

22 Spinocerebellar Ataxias, 284
H. Brent Clark and Harry T. Orr

23 Ataxia Telangiectasia, 296
Malcolm Taylor

24 Niemann–Pick Disease, 303
Marc C. Patterson

25 X–linked Adrenoleukodystrophy, 309
Deborah L. Renaud

26 Neurodegeneration with Brain Iron Accumulation, Wilson Disease, and Manganism, 317
Alisdair McNeill

Index, 327

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Anthony Schapira
Zbigniew K. Wszolek
Ted M. Dawson
Nicholas Wood
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