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Stem Cell Manufacturing

  • ID: 3744889
  • Book
  • 340 Pages
  • Elsevier Science and Technology
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Stem Cell Manufacturing discusses the required technologies that enable the transfer of the current laboratory-based practice of stem cell tissue culture to the clinic environment as therapeutics, while concurrently achieving control, reproducibility, automation, validation, and safety of the process and the product.

The advent of stem cell research unveiled the therapeutic potential of stem cells and their derivatives and increased the awareness of the public and scientific community for the topic. The successful manufacturing of stem cells and their derivatives is expected to have a positive impact in the society since it will contribute to widen the offer of therapeutic solutions to the patients. Fully defined cellular products can be used to restore the structure and function of damaged tissues and organs and to develop stem cell-based cellular therapies for the treatment of cancer and hematological disorders, autoimmune and other inflammatory diseases and genetic disorders.

- Presents the first 'Flowchart' of stem cell manufacturing enabling easy understanding of the various processes in a sequential and coherent manner- Covers all bioprocess technologies required for the transfer of the bench findings to the clinic including the process components: cell signals, bioreactors, modeling, automation, safety, etc.- Presents comprehensive coverage of a true multidisciplinary topic by bringing together specialists in their particular area- Provides the basics of the processes and identifies the issues to be resolved for large scale cell culture by the bioengineer- Addresses the critical need in bioprocessing for the successful delivery of stem cell technology to the market place by involving professional engineers in sections of the book

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1. Genetic Engineering in Stem Cell Manufacturing

2. Biomechanics in Stem Cell Manufacturing

3. Bioreactor Engineering Fundamentals for Stem Cell Manufacturing

4. Microcarrier Culture Systems for Stem Cell Manufacturing

5. Novel Single-Use Bioreactors for Scale up of Anchorage-Dependent Cell Manufacturing for Cell Therapies

6. Bioreactors and Downstream Processing for Stem Cell Manufacturing

7. Cell production system based on flexible modular platform

8. Microfluidic Devices for the Culture of Stem Cells

9. Enrichment and Separation Technologies for Stem Cell-Based Therapies

10. Expansion and Characterization Considerations for the Manufacturing of Stem Cells

11. Storage and Delivery of Stem Cells for Cellular Therapies

12. Business Models for Manufacture of Cellular Therapies

13. Stem cells for the regeneration of chronic wounds: a translational perspective
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Cabral, Joaquim M.S.Dr Joaquim M. S. Cabral is Professor of Biological Engineering, in the Department of Bioengineering at Instituto Superior Técnico (IST), Technical University of Lisbon, Portugal. He was the founder and current Head of Department of Bioengineering, and the Director of the Institute for Biotechnology and Bioengineering, a Research Laboratory Associated to the Ministry of Science, Technology and Higher Education in Portugal. His research aims at contributing to biochemical engineering science through novel developments in Bioprocess Engineering and Stem Cell Bioengineering.
da Silva, Claudia Lobato
Dr. Cláudia Lobato da Silva, born in Lisboa, Portugal, 1978, received a Diploma in Chemical Engineering (Biotechnology), Instituto Superior Técnico (IST), Technical University of Lisboa (Universidade Técnica de Lisboa, UTL), Portugal, in 2001 and got a Ph.D. in Biotechnology in 2006 at IST-UTL in collaboration with the University of Nevada, Reno, USA.

Dr. Cláudia Lobato da Silva is Assistant Professor at the Department of Bioengineering, IST-UTL, Lisboa, Portugal, and is co-author of 32 scientific articles published in international peer-reviewed journals and 4 book chapters. Her research interests include expansion of human stem cells, namely hematopoietic and mesenchymal stem cells, cellular therapies with human adult stem cells, isolation and purification of stem cells, and bioreactors for stem cell culture. At IST-UTL, Dr. Cláudia Lobato da Silva is the faculty responsible for the courses "Cell and Tissue Engineering” (since 2008/2009) and "Stem Cell Bioengineering” (since 2010/2011), whose attendees include MSc students in Biological Engineering and Biomedical Engineering. Recently, Dr. Cláudia Lobato da Silva was appointed as Associate Editor of BMC Biotechnology.
Chase, Lucas G.
Dr. Lucas Chase has extensive research experience in both adult and pluripotent stem cell biology. After obtaining a Ph.D. from the Molecular, Cellular, Developmental Biology and Genetics program at the University of Minnesota, Dr. Chase joined the Stem Cells unit at Invitrogen Corporation (now Life Technologies) in 2007, working on the development of cGMP culture media, advanced cellular models and drug discovery assays. In 2010, Dr. Chase joined Cellular Dynamics International, the world's largest producer of fully functional human cells derived from induced pluripotent stem (iPS) cells, to support development of novel cell-based models for drug discovery and basic life science applications. In addition to co-authoring numerous articles and book chapters, Dr. Chase has also co-edited two books, Mesenchymal stem Cell Assays and Applications and Mesenchymal Stem Cell Therapy.
Diogo, M. MargardiaDr Maria Margarida Diogo received her PhD degree in Biotechnology from Instituto Superior Técnico (IST) from January 2000 to April 2004. Her thesis was dedicated to the development of Bioprocesses for Production and Purification of Plasmid DNA for Gene Therapy and DNA vaccines. As a result of this work, a United States Patent was published in 2007. From April 2004 to March 2008 she received a post-doctoral fellowship to work in the field of Stem Cell Bioengineering and she is presently a Research Scientist at the Stem Cell Bioengineering Laboratory at Instituto Superior Técnico (IST).

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