Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. The book also explores innovative therapeutic strategies in preclinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer.
The book includes contributions from leading, worldwide experts in the field, helping readers embrace new hope in their quest to eradicate cancer with emerging clinical trials on treating cancer stem cells in combination with other therapies.
- Provides an authoritative and complete overview of cancer stem cells
- Includes comprehensive coverage of current therapeutic strategies targeting cancer stem cells
- Deepens a reader's technical expertise in cancer stem cell biology
Foreword by Jane Visvader and Stanton Gerson Section I. CSC Overview and Methodology
1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman
2. Overview: Cancer Stem Cell Self-Renewal Maider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke
3. Enrichment and Interrogation of Cancer Stem Cells Awad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin Lathia
Section II. CSCs in Representative Organ systems
4. Critical Updates to the Leukemia Stem Cell Model Yogen Saunthararajah
5. Breast cancer stem cells and the move toward high resolution stem cell systems Benjamin T. Spike
6. Lung Cancer Stem Cells: Drivers of Genetically and Histologically Complex Disease Christine M. Fillmore and Carla F. Kim
7. Colorectal cancer stem cells Sumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O'Brien
8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic? Antonina Kurtova and Keith Syson Chan
9. Cancer Stem Cells as New therapeutic Targets for Ovarian Cancer Yinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. Nephew
Section III. CSC Features and Mechanisms
10. Understanding Cancer Cells of Origin in Cutaneous Tumors Hyeongsun Moon, Leanne R. Donahue, Andrew C. White
11. Asymmetric Division of Cancer Stem Cells Claudia Petritsch and Xiling Shen
12. Metastasis and Metastatic Cells: A Historical Perspective and Current Analysis Kiera Rycaj and Dean G. Tang
13. Metastasis and Evasion from the Host Immune Responses Avijeet Chopra, Xia Liu, Huiping Liu
14. Cancer Stem Cells and Tumor Associated Macrophages Wenchao Zhou and Shideng Bao
15. The Mechanisms of Therapy Resistance in Cancer Stem Cells Chi-Hsuan Chang and Jeffrey M. Rosen
16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancer Praveena S. Thiagarajan, Justin D. Lathia, and Ofer Reizes
Section IV. Clinical Applications
17. From Research to the Clinic: Targeting Stem Cell Pathways in Cancer Austin Gurney and Timothy Hoey
18. Targeted Therapies for Glioma Stem Cells Swetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan
19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applications Molly Kozminsky and Sunitha Nagrath
Dr. Huiping Liu is an expert in breast cancer stem cells and metastasis. She is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Justin Lathia. Dr. Liu's research recently has been focused on thoroughly understanding the role of microRNAs in breast cancer stem cells, metastasis, and therapy resistance. The goals of the Liu laboratory are to control metastasis and eliminate the mortality associated with breast cancer and other types of cancer. She is known as an active collaborator - bridging research in basic science, engineering, and clinical medicine by engaging physicians and researchers across many institutions. Thus, she is very well known in the field and highly regarded as both a researcher and conference organizer.
Lathia, Justin Durla
Dr. Lathia is an expert in brain tumor stem cells. He is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Huiping Liu. Dr. Lathia's research has two main areas of focus: using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cells to promote their maintenance. His lab is focused on understanding cancer stem cells in real time, so they can be better eliminated by therapy and, thus, prevent tumors from forming, metastasizing, and becoming resistant to therapy.