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Practical Hemostasis and Thrombosis. 3rd Edition

  • ID: 3857752
  • Book
  • 484 Pages
  • John Wiley and Sons Ltd
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Many advances have been made in the field of thrombosis and haemostasis since the publication of the second edition of this book. This thoroughly revised third edition of Practical Hemostasis and Thrombosis encompasses the major progress in the understanding of the genetics and molecular biology, new drugs and treatment regimens available, and updated content on direct oral anticoagulants, acquired inhibitors of coagulation, and thrombotic microangiopathies. 

Designed as a practical, succinct guide, for quick reference by clinicians with everyday questions, this title guides the reader through the range of approaches available for diagnosis, management, or prevention of hemorrhagic and thrombotic diseases or disorders. 

The initial chapters of this book cover the basics of haemostasis including key principles, laboratory tests, molecular genetic tests, platelet function tests and how to evaluate the bleeding patient. The chapters then address the practice of clinical haemostasis and thrombosis, focusing on diseases and disorders including hemophilia, Von Willebrand disease, inherited coagulation defects, platelet defects, venous thromboembolism, arterial thrombosis and anticoagulation. The latter chapters cover the interface of hematology with other clinical specialities such as surgery, obstetrics, pediatrics, intensive care, cardiology, hepatology, renal medicine, oncology and transfusion medicine.

This book:

  • Provides essential practical management for all those working in the field of hemostasis and thrombosis
  • Includes new chapters on direct oral anticoagulants and, acquired inhibitors of coagulation
  • Covers in a clear and succinct format, the diagnosis, treatment and prevention of thrombotic and haemostatic disorders
  • Follows templated chapter formats for rapid referral, including key points and summary boxes, and further reading
  • Highlights controversial issues and provides advice for everyday questions encountered in the clinic

This practical guide is an invaluable resource for all trainee and practicing hematologists and provides all the information necessary to understand the clotting mechanisms, as well as how to prevent, diagnose, and treat bleeding and clotting disorders.

Praise for earlier editions

"I would heartily recommend this attractively presented book to every coagulation laboratory and every haematologist."
Royal College of Pathologists, 1 April 2011

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List of Contributors ix

1 Basic Principles Underlying Coagulation 1
Dougald M. Monroe

2 Laboratory Tests of Hemostasis 12
Steve Kitchen and Michael Makris

3 Molecular Diagnostic Approaches to Hemostasis 27
Paula James and David Lillicrap

4 Tests of Platelet Function 42
Marie Lordkipanidzé, Gillian C. Lowe and Paul Harrison

5 Evaluation of the Bleeding Patient 63
Alice Ma and Marshall Mazepa

6 Hemophilia A and B 79
Rhona M. Maclean and Michael Makris

7 Von Willebrand disease 94
Giancarlo Castaman, Alberto Tosetto and Francesco Rodeghiero

8 The Rarer Inherited Coagulation Disorders 113
Paula H.B. Bolton –Maggs, Jonathan Wilde and Gillian N. Pike

9 Acquired Inhibitors of Coagulation 124
Riitta Lassila and Elina Armstrong

10 Quantitative Platelet Disorders 134
Riten Kumar and Walter H.A. Kahr

11 Qualitative Platelet Disorders 160
Eti A. Femia Gian Marco Podda and Marco Cattaneo

12 Disseminated Intravascular Coagulation 172
Raj S. Kasthuri and Nigel S. Key

13 Thrombotic Microangiopathies 183
Marie Scully and David Kavanagh

14 Venous Thromboembolism 195
Sarah Takach Lapner, Lori–Ann Linkins and Clive Kearon

15 Myeloproliferative Neoplasms: Thrombosis and Hemorrhage 210
Brandi Reeves and Stephan Moll

16 Arterial Thrombosis 229
R. Campbell Tait and Catherine N. Bagot

17 Anticoagulation: Heparins and Vitamin K Antagonists 240
Gualtiero Palareti and Benilde Cosmi

18 The Direct Oral Anticoagulants 253
David A. Garcia, Mark A. Crowther and Walter Ageno

19 Antiphospholipid Syndrome 269
Henry G. Watson and Mark Crowther

20 Cardiovascular Medicine 282
Sreekanth Vemulapalli and Richard C. Becker

21 Cardiothoracic Surgery 299
Denise O Shaughnessy and Ravi Gill

22 Neurology 314
Michael Wang, Natalie Aucutt–Walter, Valerie L. Jewells and David Y. Huang

23 Hepatology 329
Lara N. Roberts, Raj K. Patel and Roopen Arya

24 Nephrology 340
Vimal K. Derebail and Thomas L. Ortel

25 Oncology 355
Anna Falanga and Marina Marchetti

26 Obstetrics, Contraception, and Estrogen Replacement 379
Amy Webster and Sue Pavord

27 Pediatrics 393
Mary E. Bauman, Aisha Bruce and M. Patricia Massicotte

28 Intensive and Critical Care 414
Beverley J. Hunt

29 Transfusion 433
Adrian Copplestone

Appendix 1 Reference Ranges 444
Steve Kitchen and Michael Makris

Index 452

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Nigel S. Key
Michael Makris
David Lillicrap
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