The pharmaceutical excipient production has been boosted with the advent in industries particularly pharmaceutical industry. Excipient quality plays a vital role in assuring safety, quality and efficacy of dosage forms. Standardization of excipients usually assures the customers of uniform quality across pharmaceutical products, while manufactures are assured of standardized prices of these excipients. The increased spending on healthcare by developing countries is set to increase the utilization of pharmaceutical excipients.
Binders segment is poised to dominate this market during 2020-2025.The pharmaceutical excipients market had total revenue estimated to $4256.3 million in 2020 which is expected to grow at rate of 6% till forecasted year 2025. The enormous potential for pharmaceutical excipients is also indicated by growing healthcare expenditures, rising income levels and improving health awareness amongst peoples.
What are Pharmaceutical Excipients?
An excipient can be defined as pharmacologically inactive substance in the drug delivery system which is formulated with the active pharmaceutical ingredient of a medication to prepare the product in a consumable form. Pharmaceutical excipients are inert substances, other than the pharmacologically active drug, which are included in the manufacturing process or are present in the pharmaceutical product dosage form. They enhance the properties such as bulkiness of the pharmaceutical formulation so that it can be consumed in proper manner. It also promotes the drug absorption quality of the pharmaceutical product. They do not react unwillingly with the drug and help to achieve desired drug functionality. Novel and increasingly complex excipients have been developed as the novel drug formulation delivery systems have emerged and evolved.
What are the major applications for Pharmaceutical Excipients?
Excipients are vital in formulating a dosage form of the drug or any pharmaceutical product, for adding bulk to solids (formulas) and also to facilitate proper absorption. These ingredients make up the dosage forms along with active pharmaceutical ingredients. They act as protective agents, bulking agents, flavoring and coloring agents and can also be used to improve bioavailability of drugs in some instances.
Many excipients are potential toxicants at high doses in animals, though safe in humans at therapeutic doses, including commonly used excipients such as cyclodextrins, dextran, and polyethylene glycol. Pharmaceutical excipients are vital in processing stage as they help to improve the processing of the drug delivery system during its manufacture itself. They protect, support, or enhance stability, or patient acceptability of the drug. They also assist in product identification, and enhance attributes of the overall safety in storage and also in maintaining the integrity of the drug product during storage.
Pharmaceutical Excipients Market
Market Research and Market Trends of Pharmaceutical Excipients Ecosystem
New technologies related to the controlled release of small molecule drugs have been introduced in recent developments. Lubrizol Life Science Polymers (LSP) has introduced its Pathway pharmaceutical grade thermoplastic polyurethane (TPU) excipients which offer controlled release in drug delivery systems and other applications. Lubrizol is now producing the materials under GMP conditions, which allows their use as excipients.
EMD Millipore introduced Parteck SRP 80 which is a new polyvinyl alcohol (PVA)-based functional excipient. It is specifically designed for oral sustained-release formulations, particularly direct-compression processes. Manufacturers have promised its reliable performance profile and ability to facilitate the development of robust and cost-efficient manufacturing processes.
MannKind Corporation has developed (AFREZZA) a non-injectable (orally inhaled) mealtime insulin therapy for improving glycemic control in adult patients with diabetes mellitus. MannKind is exploring the potential application of this technology for the pulmonary delivery of other drug substances. A novel excipient–fumaryl diketopiperazine (FDKP)–is inert and serves as a particle matrix (crystalline or amorphous) enhances effectiveness of the inhaled form of insulin. It carries the active drug and dissolves at the prevailing physiological pH in the lungs, where it is absorbed into the systemic circulation. Cipla tied with MannKind recently and will be responsible for obtaining regulatory approvals to distribute Afrezza in India, including approval from the Drug Controller General of India (DCGI).
The material ‘Upsalite’ has been developed by company Disruptive Materials. It was first synthesized by researchers at Uppsala University; it is highly porous with a very large surface area and enables the controlled release of APIs including ibuprofen. It has been commercialized as a water-free, disordered, amorphous magnesium carbonate. It is thought that trapping of the drug molecules in the narrow pores of the material prevents them from adopting a poorly soluble, crystalline form.
Pharmaceutical formulation experts are continuously working to improve the manufacturing process and product quality by using multi-functional excipients. It can help pharma manufacturing by improving flowability, enhancing compressibility, improving bioavailability, particle size distribution and reduced dust generation, etc. Evonik’s newly launched EUDRAGIT FS 100 is a solid version of existing EUDRAGIT FS 30 D. It allows pharmaceutical companies to use the polymer in various applications, such as hot melt extrusion, solvent spray-drying and solvent coating, which was impossible to achieve in prior decades where only the aqueous version was available. This multi-functionality approach allows overall new development possibilities within the pharmacy industry.
Who are the Major Players in Pharmaceutical Excipients market?
The players profiled in the report include BASF SE, Dow Chemical, FMC Chemical and Nutrition, Fuji Chemical Industry, Evonik, Ashland Inc., Roquette Group, The Lubrizol Corp., Colorcon, Croda International Plc.
What is our report scope?
The report incorporates in-depth assessment of the competitive landscape, product market sizing, product benchmarking, market trends, product developments, financial analysis, strategic analysis and so on to gauge the impact forces and potential opportunities of the market. Apart from this the report also includes a study of major developments in the market such as product launches, agreements, acquisitions, collaborations, mergers and so on to comprehend the prevailing market dynamics at present and its impact during the forecast period 2020-2025.
Key Takeaways from this Report
- Evaluate market potential through analyzing growth rates (CAGR %), Volume (Units) and Value ($M) data given at country level – for product types, end use applications and by different industry verticals.
- Understand the different dynamics influencing the market – key driving factors, challenges and hidden opportunities.
- Get in-depth insights on your competitor performance – market shares, strategies, financial benchmarking, product benchmarking, SWOT and more.
- Analyse the sales and distribution channels across key geographies to improve top-line revenues.
- Understand the industry supply chain with a deep-dive on the value augmentation at each step, in order to optimize value and bring efficiencies in your processes.
- Get a quick outlook on the market entropy – M&A’s, deals, partnerships, product launches of all key players for the past 4 years.
- Evaluate the supply-demand gaps, import-export statistics and regulatory landscape for more than top 20 countries globally for the market.
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1.1. Definitions and Scope
2. Pharmaceutical Excipients Market - Executive summary
2.1. Market Revenue, Market Size and Key Trends by Company
2.2. Key Trends by type of Application
2.3. Key Trends segmented by Geography
3. Pharmaceutical Excipients Market
3.1. Comparative analysis
3.1.1. Product Benchmarking - Top 10 companies
3.1.2. Top 5 Financials Analysis
3.1.3. Market Value split by Top 10 companies
3.1.4. Patent Analysis - Top 10 companies
3.1.5. Pricing Analysis
4. Pharmaceutical Excipients Market Forces
4.4. Porters five force model
4.4.1. Bargaining power of suppliers
4.4.2. Bargaining powers of customers
4.4.3. Threat of new entrants
4.4.4. Rivalry among existing players
4.4.5. Threat of substitutes
5. Pharmaceutical Excipients Market - Strategic analysis
5.1. Value chain analysis
5.2. Opportunities analysis
5.3. Product life cycle
5.4. Suppliers and distributors Market Share
6. Pharmaceutical Excipients Market – By Product (Market Size -$Million / $Billion)
6.1. Market Size and Market Share Analysis
6.2. Application Revenue and Trend Research
6.3. Product Segment Analysis
188.8.131.52.2. Actual Sugars
184.108.40.206.3. Sugar Alcohols
220.127.116.11.4. Artificial Sweeteners
18.104.22.168.1. Modified Starch
22.214.171.124.2. Dried Starch
126.96.36.199.3. Converted Starch
188.8.131.52.1. Cellulose Ethers
184.108.40.206.2. Cellulose Esters
220.127.116.11.3. Microcrystalline Cellulose
18.104.22.168.4. Artificial Sweeteners
22.214.171.124.1.1. Polyethylene Glycol
126.96.36.199.1.2. Propylene Glycol
188.8.131.52.3. Mineral Hydrocarbons
184.108.40.206.3.2. Mineral Waxes
220.127.116.11.3.3. Mineral Oils
18.104.22.168.4. Acrylic Polymers
22.214.171.124.5. Other Petrochemical Excepients
126.96.36.199.1. Fatty Alcohols
188.8.131.52.2. Mineral Stearates
184.108.40.206.4. Other Oleochmical Excipients
220.127.116.11. Calcium Phosphates
18.104.22.168. Calcium Carbonate
22.214.171.124. Calcium Sulfate
126.96.36.199. Metallic Oxides
7. Pharmaceutical Excipients Market – By Chemistry (Market Size -$Million / $Billion)
7.4. Synthetic Source
8. Pharmaceutical Excipients Market – By Functionality (Market Size -$Million / $Billion)
8.1. Fillers & Diluents
8.6. Flavoring Agents
8.7. Suspension & Viscosity Agents
9. Pharmaceutical Excipients Market – By Route of Administration (Market Size -$Million / $Billion)
10. Pharmaceutical Excipients - By Geography (Market Size -$Million / $Billion)
10.1. Pharmaceutical Excipients Market - North America Segment Research
10.2. North America Market Research (Million / $Billion)
10.2.1. Segment type Size and Market Size Analysis
10.2.2. Revenue and Trends
10.2.3. Application Revenue and Trends by type of Application
10.2.4. Company Revenue and Product Analysis
10.2.5. North America Product type and Application Market Size
10.2.5.4. Rest of North America
10.3. Pharmaceutical Excipients - South America Segment Research
10.4. South America Market Research (Market Size -$Million / $Billion)
10.4.1. Segment type Size and Market Size Analysis
10.4.2. Revenue and Trends
10.4.3. Application Revenue and Trends by type of Application
10.4.4. Company Revenue and Product Analysis
10.4.5. South America Product type and Application Market Size
10.4.5.7. Costa Rica
10.4.5.8. Rest of South America
10.5. Pharmaceutical Excipients - Europe Segment Research
10.6. Europe Market Research (Market Size -$Million / $Billion)
10.6.1. Segment type Size and Market Size Analysis
10.6.2. Revenue and Trends
10.6.3. Application Revenue and Trends by type of Application
10.6.4. Company Revenue and Product Analysis
10.6.5. Europe Segment Product type and Application Market Size
10.6.5.9. Rest of Europe
10.7. Pharmaceutical Excipients – APAC Segment Research
10.8. APAC Market Research (Market Size -$Million / $Billion)
10.8.1. Segment type Size and Market Size Analysis
10.8.2. Revenue and Trends
10.8.3. Application Revenue and Trends by type of Application
10.8.4. Company Revenue and Product Analysis
10.8.5. APAC Segment – Product type and Application Market Size
10.8.5.4. South Korea
11. Pharmaceutical Excipients Market - Entropy
11.1. New product launches
11.2. M&A's, collaborations, JVs and partnership
12. Pharmaceutical Excipients Market Company Analysis
12.1. Market Share, Company Revenue, Products, M&A, Developments
12.2. BASF SE
12.3. Dow Chemical
12.4. FMC Chemical and Nutrition
12.5. Fuji Chemical Industry
12.7. Ashland Inc.
12.8. Roquette Group
12.10. Croda International Plc
13. Pharmaceutical Excipients Market - Appendix
14. Pharmaceutical Excipients Market - Methodology
14.1. Research Methodology
14.1.1. Company Expert Interviews
14.1.2. Industry Databases
14.1.4. Company News
14.1.5. Company Annual Reports
14.1.6. Application Trends
14.1.7. New Products and Product database
14.1.8. Company Transcripts
14.1.9. R&D Trends
14.1.10. Key Opinion Leaders Interviews
14.1.11. Supply and Demand Trends