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Vulvar Cancer - Pipeline Insight, 2022

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    Clinical Trials

  • 70 Pages
  • June 2022
  • Region: Global
  • DelveInsight
  • ID: 4037779
UP TO OFF until Dec 31st 2022
This Vulvar Cancer - Pipeline Insight, 2022 report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Vulvar Cancer pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Vulvar Cancer Understanding


Vulvar Cancer: Overview


Vulvar cancer (also known as vulval cancer, cancer of the vulva or vulva cancer) is a cancer that occurs in any part of the external female genitals. Vulvar cancer most commonly develops in the labia minora (inner lips), the labia majora (outer lips), and the perineum (skin between the vagina and the anus). About 90% of vulvar cancers are squamous cell carcinomas; about 5% are melanomas. Others include adenocarcinomas and transitional cell, adenoid cystic, and adenosquamous carcinomas; all may originate in Bartholin glands. Sarcomas and basal cell carcinomas with underlying adenocarcinoma also occur. Most patients with vulvar cancer present with a palpable vulvar lesion, frequently noticed by the woman or by a clinician during pelvic examination. Women often have a long history of pruritus. They may not present until cancer is advanced. The lesion may become necrotic or ulcerated, sometimes resulting in bleeding or a watery vaginal discharge. Melanomas may appear bluish black, pigmented, or papillary. Surgery is the main treatment for vulvar cancer. The type of operation will depend on the stage of the cancer.

Vulvar Cancer - Pipeline Insight, 2022 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Vulvar Cancer pipeline landscape is provided which includes the disease overview and Vulvar Cancer treatment guidelines. The assessment part of the report embraces, in depth Vulvar Cancer commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Vulvar Cancer collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

  • A better understanding of disease pathogenesis contributing to the development of novel therapeutics for Vulvar Cancer.
  • In the coming years, the Vulvar Cancer market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies and academics that are working to assess challenges and seek opportunities that could influence Vulvar Cancer R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
  • A detailed portfolio of major pharma players who are involved in fueling the Vulvar Cancer treatment market. Several potential therapies for Vulvar Cancer are under investigation. With the expected launch of these emerging therapies, it is expected that there will be a significant impact on the Vulvar Cancer market size in the coming years.
  • Our in-depth analysis of the pipeline assets (in early-stage, mid-stage and late stage of development for the treatment of Vulvar Cancer) includes therapeutic assessment and comparative analysis. This will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Vulvar Cancer Emerging Drugs Chapters


This segment of the Vulvar Cancer report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Vulvar Cancer Emerging Drugs


Vudalimab: Xencor

Vudalimab is a bispecific antibody that simultaneously targets immune checkpoint receptors PD-1 and CTLA-4 and is designed to promote tumor-selective T-cell activation. Xencor's XmAb® Bispecific Fc Domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life, stability and ease of manufacture on vudalimab. XmAb bispecific Fc domains have been engineered to eliminate Fc gamma receptor (FcγR) binding, with the intent to prevent activation and/or depletion of T cells via engagement by FcγR-expressing cells. In preclinical studies, dual blockade of PD-1 and CTLA-4 with vudalimab significantly enhanced T cell proliferation and activation, and anti-tumor activity in vivo.

PEN-866: Tarveda Therapeutics

PEN-866 is a miniature drug conjugate that selectively binds to the intracellular target Heat Shock Protein 90 (HSP90) and is linked to a topoisomerase 1 inhibitor (SN-38), a potent anti-cancer payload. PEN-866 accumulates and is retained in tumors. As the SN-38 payload is cleaved over time, there is a sustained release of SN-38, resulting in prolonged DNA damage and tumor regressions in multiple patient-derived and other xenograft tumor models. PEN-866 is the first miniature drug conjugate from Tarveda's HSP90 binding drug conjugate platform.

Vulvar Cancer: Therapeutic Assessment


This segment of the report provides insights about the different Vulvar Cancer drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Vulvar Cancer


There are approx. 12+ key companies which are developing the therapies for Vulvar Cancer. The companies which have their Vulvar Cancer drug candidates in the most advanced stage, i.e. phase II include Xencor.

Phases


This report covers around 12+ products under different phases of clinical development like

  • Late stage products (Phase III)
  • Mid-stage products (Phase II)
  • Early-stage product (Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Vulvar Cancer pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Inhalation
  • Inhalation/Intravenous/Oral
  • Intranasal
  • Intravenous
  • Intravenous/ Subcutaneous
  • NA
  • Oral
  • Oral/intranasal/subcutaneous
  • Parenteral
  • Subcutaneous
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Antibody
  • Antisense oligonucleotides
  • Immunotherapy
  • Monoclonal antibody
  • Peptides
  • Protein
  • Recombinant protein
  • Small molecule
  • Stem Cell
  • Vaccine
  • Product Type

The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Vulvar Cancer: Pipeline Development Activities


The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Vulvar Cancer therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Vulvar Cancer drugs.

Vulvar Cancer Report Insights

  • Vulvar Cancer Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Vulvar Cancer Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions Answered


Current Treatment Scenario and Emerging Therapies:

  • How many companies are developing Vulvar Cancer drugs?
  • How many Vulvar Cancer drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Vulvar Cancer?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Vulvar Cancer therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Vulvar Cancer and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Akaza Bioscience
  • Xencor
  • Tarveda Therapeutics
  • Frantz Viral Therapeutics, LLC
  • Brooklyn ImmunoTherapeutics, LLC
  • ISA Pharmaceuticals BV
  • Oryx
  • PDS Biotechnology
  • SQZ Biotech
  • Privo Technologies
  • Precigen
  • Antiva Biosciences
  • CUE BIOPHARMA
  • Arovella Therapeutics

Key Players

  • TAK-242
  • Vudalimab
  • PEN-866
  • Artesunate
  • IRX-2
  • ISA101
  • VicOryx
  • PRV111
  • PRGN-2009
  • ABI-2280
  • CUE-101


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Table of Contents

IntroductionExecutive Summary
Vulvar Cancer: Overview
  • Causes
  • Mechanism of Action
  • Signs and Symptoms
  • Diagnosis
  • Disease Management

Pipeline Therapeutics
  • Comparative Analysis

Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type

Vulvar Cancer - Analytical Perspective
Late Stage Products (Phase III)
  • Comparative Analysis

Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities

Mid Stage Products (Phase II)
  • Comparative Analysis

Vudalimab: Xencor
  • Product Description
  • Research and Development
  • Product Development Activities

Early Stage Products (Phase I/II)
  • Comparative Analysis

VicOryx: Oryx
  • Product Description
  • Research and Development
  • Product Development Activities

Preclinical and Discovery Stage Products
  • Comparative Analysis

Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities

Inactive Products
  • Comparative Analysis

Vulvar Cancer Key CompaniesVulvar Cancer Key ProductsVulvar Cancer - Unmet NeedsVulvar Cancer - Market Drivers and BarriersVulvar Cancer - Future Perspectives and ConclusionVulvar Cancer Analyst ViewsVulvar Cancer Key CompaniesAppendix

Companies Mentioned

A selection of companies mentioned in this report includes:

  • Akaza Bioscience
  • Xencor
  • Tarveda Therapeutics
  • Frantz Viral Therapeutics, LLC
  • Brooklyn ImmunoTherapeutics, LLC
  • ISA Pharmaceuticals BV
  • Oryx
  • PDS Biotechnology
  • SQZ Biotech
  • Privo Technologies
  • Precigen
  • Antiva Biosciences
  • CUE BIOPHARMA
  • Arovella Therapeutics