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Next-Generation Sequencing: Emerging Clinical Applications and Global Markets

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    Report

  • 492 Pages
  • January 2024
  • Region: Global
  • BCC Research
  • ID: 5332698

The scope of the report includes clinical NGS technologies, applications, industries, initiatives, patents, and companies. The markets for NGS-based diagnostics are given for the years 2020, 2021, 2022, 2023 and 2028.



This report reviews the main sequencing technologies and explains why genetic variation is important in clinical testing. It then discusses some of the significant research initiatives that impact clinical NGS applications. Liquid biopsy formats are discussed. The main market driving forces are also discussed.

The report examines the markets by test complexity, clinical indication and test purpose. Test complexity refers to the plex level (i.e., the number of genetic markers that can be analyzed within a sample) and coverage (e.g., the extent to which the genome is covered) of the test. Examining the market by test complexity provides valuable insight into which products (e.g., sample preparation, NGS instrument, informatics, etc.) will be in demand in the future.

The report provides market data and forecasts for NGS diagnostics by specific applications, including those for oncology, cardiovascular diseases, clinical microbiology/infectious diseases, Mendelian disorders, metabolic/immune disorders, neurological disorders, reproductive health, and transplant medicine.

Specific geographic markets are discussed, namely North America, Europe, Asia-Pacific, and the Rest of the World.

Industry sectors analyzed include DNA sequencing instruments; long-read sequencing; sequencing informatics; target enrichment; CTC capture and detection; liquid biopsy; cancer screening/early detection; direct-to-consumer testing; and noninvasive prenatal testing.

More than 100 companies in the clinical NGS industry are profiled in this report.

The publisher also provides a summary of the recent, primary industry acquisitions and strategic alliances, including key alliance trends.

Report Includes

  • 41 data tables and 237 additional tables
  • An overview of the global market for emerging clinical applications of next-generation sequencing
  • Analysis of global market trends, featuring historical revenue data for 2020 to 2022, estimates for 2023, as well as forecasts for 2028, including projections of compound annual growth rates (CAGRs) through 2028
  • Evaluation of the current market size and revenue growth prospects, accompanied by a market share analysis by disease indication, test complexity, test purpose, application and geographic region
  • Discussion of market opportunities for clinical NGS products, clinical applications, industry structure, regulatory scenarios and use of NGS-based diagnostics and technologies
  • Coverage of genome mapping programs, technological advances and innovations in NGS platforms, and the Ion Torrent Genexus System from Thermo Fisher Scientific and the Magnis NGS Prep System lfrom Agilent Technologies Inc
  • Description of NGS-oriented tests such as non-invasive prenatal testing (NIPT) and pre-implantation genetic testing (PGT), and a discussion of their advantages
  • Market share analysis of the key companies and a look at their proprietary technologies, strategic alliances and other key market strategies, plus a patent analysis
  • Profiles of the leading players, including Illumina Inc., Thermo Fisher Scientific Inc., QIAGEN, Agilent Technologies Inc., and BGI Genomics

Table of Contents

Chapter 1 Introduction
  • Study Goals and Objectives
  • Reasons for Doing This Study
  • Scope of Report
  • Information Sources
  • Methodology
  • What’s New in This Report?
  • Geographic Breakdown
  • Segmentation Breakdown
Chapter 2 Summary and Highlights
  • Market Outlook
  • Market Summary
Chapter 3 Overview
  • Introduction
  • Liquid and Tissue Biopsy
  • Clinical NGS Market
  • Growth Drivers of Clinical NGS
  • Key Trends
  • Industry
Chapter 4 Technology Background
  • Importance of DNA
  • Genetic Variation and Analysis
  • Genetic Analysis Technologies
  • Sequencing in Clinical Applications
  • Sequencing Technologies
  • History of DNA Sequencing
  • Sanger Sequencing Technology
  • NGS Platforms
  • Short-Read Platforms
  • Long-Read Platforms
  • Informatics Technologies
  • Base Calling
  • Mapping to a Reference Sequence
  • Variant Analysis
  • Artificial Intelligence Technologies
  • Clinical Sequencing Technology Challenges
Chapter 5 Clinical NGS Initiatives and Emerging Technologies
  • R&D Initiatives and Programs
  • 1+ Million Genomes
  • Access to Treatment and Testing (ACTT)
  • Access to Comprehensive Genomic Profiling Coalition (ACGP)
  • Africa Pathogen Genomics Initiative
  • Blood Profiling Atlas
  • Cancer-ID
  • Cancer Moon Shots Program
  • China Precision Medicine Initiative
  • ClinGen
  • CTC Trap Consortium
  • diaRNAgnosis Project
  • Early Cancer Detection Consortium
  • EpiFemCare
  • France Genomic Medicine Plan
  • Friends of Cancer Research Project
  • Genomic Medicine Sweden
  • HCA-Organoid
  • Human Cell Atlas
  • Human Immunomics Initiative
  • Immunomonitor Consortium
  • Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy Program
  • Intervene
  • Liquid Biopsies and Imaging for Improved Cancer Care
  • Liquid Biopsy-Based Malignant Tumor Early Screening Technology Research and Development Project
  • Liver Cancer Early Screening Comprehensive Prevention and Control Project
  • Lung Cancer Genomic Screening Project for Individualized Medicine in Asia
  • Million Veteran Program
  • Medical Genome Initiative
  • MedSeq
  • Precision Medicine Initiative
  • Prompt
  • QuIP Project
  • SPHERES
  • Target ALS Diagnosis Initiative
  • TopMed
  • Treehouse Childhood Cancer Initiative
  • Very Rare Cancer Consortium
  • Worldwide Innovative Networking (WIN) Consortium
  • Single-Cell Research
  • Cambridge Single-Cell Analysis Core Facility
  • Harvard Medical School Single-Cell Core
  • Mayo Medical Genome Facility
  • National Center for Single-Cell Biology
  • Next-Generation Single-Cell Analysis Program
  • Single-Cell Analysis Core
  • UC San Francisco Single-Cell Analysis Center
  • The Wistar Institute of Anatomy and Biology
  • Population Sequencing Projects
Chapter 6 Clinical NGS Applications
  • Introduction
  • Cancer Applications
  • Precision Medicine
  • Liquid Biopsy Biomarkers
  • Mendelian Disorders Applications
  • Reproductive Health Applications
  • Noninvasive Prenatal Testing
  • Newborn Screening
  • Microbiology and Infectious Disease Applications
  • Complex Disorders Applications
Chapter 7 Clinical NGS Industry
  • Sequencing Instrument Industry
  • Companies
  • Third-Generation Sequencing Industry
  • Sequencing Informatics Industry
  • Target Enrichment and Amplification Industry
  • CTC Capture and Detection Industry
  • Liquid Biopsy Assay Industry
  • Liquid Biopsy Cancer Screening/Early Detection Industry
  • Health-Focused DTC Genetic Testing Industry: Two Market Models
  • DTC Clinical Health Genetic Testing Industry
  • Noninvasive Prenatal Testing (NIPT) Industry
Chapter 8 ESG Development
  • Introduction to ESG
  • The Sustainability of NGS in Industry
  • Case Study
  • Publisher Viewpoint
Chapter 9 Acquisitions and Strategic Alliances
  • Acquisitions
  • Strategic Alliances
  • Key Trends
Chapter 10 Clinical NGS Markets
  • Market Dynamics
  • Market Drivers
  • Impact of COVID-19 on the Clinical NGS Markets
  • Clinical NGS Market by Disease Category
  • Clinical NGS Market by Test Complexity
  • Clinical NGS Market by Purpose of Test
  • Clinical NGS Market in Oncology
  • Market by Indication in Oncology
  • NGS Market in Oncology by Purpose of Test
  • NGS Market in Oncology by Test Complexity
  • Clinical NGS Market in Cardiology
  • NGS Market in Cardiology by Purpose of Test
  • NGS Market in Cardiology by Test Complexity
  • Clinical NGS Market in Mendelian Disorders
  • NGS Market in Mendelian Disorders by Test Complexity
  • Clinical NGS Market in Metabolic/Immune Disorders
  • NGS Market in Metabolic/Immune Disorders by Purpose of Test
  • NGS Market in Metabolic/Immune Disorders by Test Complexity
  • Clinical NGS Market in Neurology
  • NGS Market in Neurology by Test Purpose
  • NGS Market in Neurology by Test Complexity
  • Clinical NGS Market in Reproductive Health
  • Reproductive Health Market by Test Application
  • NGS Market in Reproductive Health by Purpose of Test
  • NGS Market in Reproductive Health by Test Complexity
  • Clinical NGS Market in Microbiology and Infectious Diseases
  • NGS Market in Microbiology and Infectious Diseases by Purpose of Test
  • NGS Market in Microbiology and Infectious Diseases by Test Complexity
  • Clinical NGS Market in Transplantation
  • NGS Market in Transplantation by Organ Type
  • NGS Market in Transplantation by Purpose of Test
  • NGS Market in Transplantation by Test Complexity
  • Clinical NGS Market by Region
  • Global Market for NGS in Oncology by Region
  • Global Market for NGS in Reproductive Health by Region
  • Global Market for NGS in Transplantation by Region
Chapter 11 Patent Review
  • Patents on Circulating Tumor Cells
  • Patents on Exosomes
  • Patents on Cell-Free DNA
  • Patents Related to Biomarkers
  • Patent Considerations for the Use of Artificial Intelligence in Cancer Diagnostics
  • Liquid Biopsy Patent Litigation
Chapter 12 Company Profiles
  • Competitive Landscape
  • Top 5 Companies
  • AGILENT TECHNOLOGIES INC.
  • BGI GENOMICS CO. LTD
  • ILLUMINA INC.
  • QIAGEN
  • THERMO FISHER SCIENTIFIC INC.
  • Other Companies
  • ACCURAGEN HOLDINGS
  • ADAPTIVE BIOTECHNOLOGIES
  • ALCEN
  • AMBRY GENETICS
  • AMOY DIAGNOSTICS CO. LTD.
  • ANGLE PLC
  • APOSTLE SCIENCES
  • ARCEDI BIOTECH APS
  • ARMONICA TECHNOLOGIES INC.
  • ARUP LABORATORIES
  • ASURAGEN INC.
  • BAYLOR GENETICS
  • BECTON, DICKINSON AND CO.
  • BERRY GENOMICS BEIJING
  • BIOCAPTIVA LTD.
  • BIOCEPT INC.
  • BIODESIX
  • BIOFLUIDICA
  • BIOLIDICS LTD
  • BIOLOGICAL DYNAMICS
  • BIOMODAL
  • BIONANO GENOMICS
  • BIO-RAD LABORATORIES INC.
  • BIO-TECHNE
  • C2I GENOMICS
  • CAPIO BIOSCIENCES
  • CAREDX INC.
  • CARIS LIFE SCIENCE
  • CEGAT GMBH
  • CELL MICROSYSTEMS
  • CENTRILLION GENOMICS TECHNOLOGIES
  • CLARET BIOSCIENCE
  • CLEAR NOTE HEALTH
  • CLINICAL GENOMICS TECHNOLOGIES
  • CYCLOMICS
  • CYGNUS BIOSCIENCES CO. LTD.
  • DANAHER
  • DANTE LABS
  • DATAR CANCER GENETICS LTD.
  • DELFI DIAGNOSTICS
  • DIACARTA
  • DIAGNOLOGIX LLC
  • DIAGNOMICS INC.
  • DIAMIR BIO
  • DNALYTICS
  • DNANEXUS INC.
  • EARLYDIAGNOSTICS
  • EONE-DIAGNOMICS GENOME CENTER CO. LTD.
  • EPIC SCIENCES
  • EPIGENOMICS AG
  • EUROFINS GENOMICS
  • EVERLY HEALTH INC.
  • EXACT SCIENCES CORP.
  • EXOPERT
  • EXOSOMICS INC.
  • EZLIFE BIO
  • FABRIC GENOMICS INC.
  • F. HOFFMANN-LA ROCHE LTD
  • FLUXION BIOSCIENCES INC.
  • FREENOME HOLDINGS INC.
  • FULGENT GENETICS
  • FULL GENOMES CORP.
  • GENE BY GENE LTD.
  • GENEDX LLC
  • GENESEQ BIOSCIENCES
  • GENOMONCOLOGY LLC
  • GENOSABER
  • GRAIL INC.
  • GUARDANT HEALTH
  • HELIO GENOMICS
  • HELIX INC.
  • HTG MOLECULAR DIAGNOSTICS INC.
  • IMAGIA CANEXIA HEALTH
  • INCELLDX INC.
  • INEX INNOVATE PRIVATE LTD
  • INOVIQ
  • INTERPACE BIOSCIENCES INC.
  • INVITAE CORP.
  • INVIVOSCRIBE INC.
  • JABREHOO MED TECH CO. LTD.
  • JBS SCIENCE
  • JUMPCODE GENOMICS INC.
  • KONINKLIJKE PHILIPS N.V.
  • LABGENOMICS CO. LTD.
  • LABORATORY CORPORATION OF AMERICA HOLDINGS
  • LIQUID BIOPSY LABS
  • LUCENCE HEALTH INC.
  • LUNGLIFE AI INC.
  • MACROGEN INC.
  • MAPMYGENOME
  • MDXHEALTH INC.
  • MEDGENOME
  • MEDICOVER GENETICS
  • MENARINI SILICON BIOSYSTEMS SPA
  • MERCK KGAA
  • MICAREO RARE CELL DIAGNOSTICS
  • MICRONOMA INC.
  • MIR SCIENTIFIC
  • MUTANTDX
  • MYRIAD GENETICS INC.
  • NANOSTRING TECHNOLOGIES INC.
  • NATERA INC.
  • NEBULA GENOMICS
  • NEOGENOMICS LABORATORIES
  • NEW ENGLAND BIOLABS
  • NEW HORIZON HEALTH LTD.
  • NOVIGENIX SA
  • NOVOGENE CO. LTD.
  • NRICHDX INC.
  • NUPROBE INC.
  • NX PRENATAL INC.
  • ONCIMMUNE HOLDINGS PLC
  • ONCOCYTE CORP.
  • ONCODNA
  • OPKO HEALTH
  • ORCHID
  • OXFORD NANOPORE TECHNOLOGIES LTD.
  • PACIFIC BIOSCIENCES OF CALIFORNIA INC.
  • PANGAEA ONCOLOGY
  • PERSONAL GENOME DIAGNOSTICS INC.
  • PERSONALIS INC.
  • PHASE SCIENTIFIC
  • PIERIANDX
  • PREDICINE
  • PRENETICS GROUP
  • QCDX LLC
  • QUANTAPORE
  • QUANTGENE INC.
  • QUANTUMDX
  • QUEST DIAGNOSTICS
  • RARECELLS INC.
  • RAVGEN
  • REAL TIME GENOMICS
  • RESOLUTION BIOSCIENCE INC.
  • SAGA DIAGNOSTICS AB
  • SANO GENETICS
  • SCREENCELL
  • SEEKIN INC.
  • SEQUENCING.COM
  • SEVEN BRIDGES GENOMICS INC.
  • SINGLE TECHNOLOGIES
  • SMARTCATCH
  • STAGEZERO LIFE SCIENCES. LTD.
  • STRAND
  • STRATA ONCOLOGY
  • SYAPSE INC.
  • SYSMEX INOSTICS GMBH
  • TAKARA BIO INC.
  • TELEXOS GMBH
  • TWINSTRAND BIOSCIENCES INC.
  • TWIST BIOSCIENCE
  • UNCHAINED LABS
  • UNIVERSAL DX
  • VELA DIAGNOSTICS
  • VERACYTE
  • VOLITIONRX
  • VORTEX BIOSCIENCES
  • YOURGENE HEALTH
  • YIKON GENOMICS CO. LTD.
List of Tables
Table A: Scope of the Report
Summary Table: Global Market for Clinical Applications of Next-Generation Sequencing, by Disease Class, Through 2028
Table 1: Global Market for Clinical Next-Generation Sequencing, by Disease Type, Through 2028
Table 2: Forces Influencing Growth in the Clinical NGS Market
Table 3: Key Trends in the Clinical NGS Testing Market
Table 4: Clinical NGS Industry Subsectors
Table 5: DNA Chemical Building Blocks
Table 6: DNA Translation and Transcription
Table 7: Long-Range DNA Structure
Table 8: Genetic Variant Types
Table 9: Molecular Diagnostic Technology Platforms
Table 10: Genome Coverage of PCR, Microarray and NGS Technology Platforms
Table 11: Genetic Testing Coverage
Table 12: Key Near- to Mid-term Segments of NGS Diagnostics
Table 13: DNA Sequencing Historical Timeline, 1977-2023
Table 14: Sequencing Technology Development, 1990-2020
Table 15: Cost of Sequencing a Single Human Genome, 2001-2022
Table 16: Summary of Sanger Sequencing
Table 17: Improvements in Sanger Sequencing
Table 18: NGS Technologies
Table 19: Illumina NGS Workflow
Table 20: Thermo Fisher Scientific NGS Workflow
Table 21: NGS Bioinformatics Workflow
Table 22: Sequence Annotation Steps
Table 23: Types of AI in Healthcare
Table 24: Future Challenges in Implementing Clinical NGS
Table 25: Clinical NGS Research and Development Initiatives and Programs
Table 26: Single-Cell Core Research Facilities
Table 27: Population Sequencing Projects
Table 28: Clinical NGS Near- to Mid-term Applications
Table 29: Personalized Medicine Driven by Common Cancer Genetic Mutations
Table 30: Liquid Biopsy Biomarkers
Table 31: NGS-Based Cancer Diagnostics Market Segments
Table 32: Mendelian Disorders Applications
Table 33: Reproductive Health Screening Applications
Table 34: Ethical Issues Associated with NIPT
Table 35: Microbiology/Infectious Disease Applications
Table 36: Complex Disorders Applications
Table 37: Key Segments and Trends in the Clinical NGS Industry
Table 38: NGS and 3GS Industry Company Positioning
Table 39: Long-Read Sequencing Industry
Table 40: Sequencing Informatics Industry
Table 41: NGS Target Enrichment Industry
Table 42: CTC Separations Industry
Table 43: Liquid Biopsy Assay Industry: Company Focus
Table 44: Examples of NGS-Based Liquid Biopsy Market Differentiation
Table 45: Multi-Cancer Screening Test Desired Features
Table 46: Shed Rates of Various Cancers
Table 47: Cancer Screening Liquid Biopsy Industry
Table 48: Thrive Earlier Detection (Exact Sciences) Cancer Targets
Table 49: Colorectal Cancer Early Detection/Screening Liquid Biopsy Industry
Table 50: Key Clinical Trials on Single- and Multi-Cancer Liquid Biopsy Assays
Table 51: Clinical-Grade Health DTC Genetic Testing Companies
Table 52: NIPT Industry
Table 53: Key Focus Areas in ESG Metrics
Table 54: ESG Rankings for Major Companies in the NGS Arena
Table 55: Illumina 2030 ESG Targets
Table 56: Clinical NGS Industry Acquisitions, January 2019-October 2023
Table 57: Strategic Alliances in Clinical NGS, January 2019-April 2021
Table 58: Key Forces Driving Growth in Clinical NGS and Their Implications
Table 59: Global Market for Clinical NGS, by Disease Category, Through 2028
Table 60: Global Market for Clinical NGS, by Test Complexity, Through 2028
Table 61: Global Market for Clinical NGS, by Purpose of Test, Through 2028
Table 62: Limitations of Tissue Biopsy in Cancer Applications
Table 63: Low-Frequency Mutation Detection
Table 64: Global Market for Clinical NGS in Oncology, by Indication, Through 2028
Table 65: Five-Year Survival Rate for Ovarian Cancer
Table 66: National Institutes of Health Liquid Biopsy Early Detection Initiative
Table 67: Clinical Trials on Lung Cancer Liquid Biopsies
Table 68: Global Market for Clinical NGS in Oncology, by Purpose of Test, Through 2028
Table 69: MRI and Liquid Biopsy Methods
Table 70: Early Detection Tissue of Origin Approaches
Table 71: Global Market for Clinical NGS in Oncology, by Test Complexity, Through 2028
Table 72: European Society of Medical Oncology NGS Recommendations for Metastatic Cancers, August 2020
Table 73: Global Market for Clinical NGS in Cardiology Diagnostics, by Purpose of Test, Through 2028
Table 74: NGS-Based Dilated Cardiomyopathy Test Providers
Table 75: Global Market for Clinical NGS in Cardiology Diagnostics, by Test Complexity, Through 2028
Table 76: Global Market for Clinical NGS in Mendelian Disorder Diagnostics, by Purpose of Test, Through 2028
Table 77: Global Market for Clinical NGS in Mendelian Disorder Diagnostics, by Test Complexity, Through 2028
Table 78: Global Market for Clinical NGS in Metabolic and Immune Disorder Diagnostics, by Purpose of Test, Through 2028
Table 79: Multiple Sclerosis Diagnostic Technologies
Table 80: Global Market for Clinical NGS in Metabolic and Immune Disorder Diagnostics, by Test Complexity, Through 2028
Table 81: Global Market for Clinical NGS in Neurological Diagnostics, by Purpose of Test, Through 2028
Table 82: Global Market for Clinical NGS in Neurological Diagnostics, by Test Complexity, Through 2028
Table 83: Global Market for Clinical NGS in Reproductive Health, by Application, Through 2028
Table 84: Global NGS-Based NIPT Market, by Risk Type, Through 2028
Table 85: Global Market for Clinical NGS in Reproductive Health, by Purpose of Test, Through 2028
Table 86: Global Market for Clinical NGS in Reproductive Health, by Test Complexity, Through 2028
Table 87: NGS-Based Infectious Disease Landscape
Table 88: Global Market for Clinical NGS-Based Microbiology and Infectious Disease Diagnostics, by Purpose of Test, Through 2028
Table 89: Global Market for Clinical NGS-Based Microbiology and Infectious Disease Diagnostics, by Test Complexity, Through 2028
Table 90: NGS in Infectious Disease Diagnostics
Table 91: Global Market for Clinical NGS in Transplantations, by Organ, Through 2028
Table 92: Transplant Procedures Performed in the U.S., by Organ, 2018-2020
Table 93: Global Market for Clinical NGS in Transplantation, by Purpose of Test, Through 2028
Table 94: Global Market for Clinical NGS in Transplantation, by Test Complexity, Through 2028
Table 95: Global Market for Clinical NGS, by Region, Through 2028
Table 96: Global Market for Clinical NGS in Oncology, by Region, Through 2028
Table 97: Global Market for NGS in Reproductive Health, by Region, Through 2028
Table 98: Global Market for Clinical NGS in Transplantation, by Region, Through 2028
Table 99: Patent Activity on Circulating Tumor Cells (CTCs), by Country/Region, January 2010-June 2020
Table 100: List of Select Patents Filed for Circulating Tumor Cells, 2020-2023
Table 101: Patent Activity on Exosomes, by Country/Region, January 2010-December 2020
Table 102: List of Select Patents Filed for Exosomes, 2020-2023
Table 103: Patent Activity on Cell-Free DNA, by Country/Region, January 2010-December 2020
Table 104: List of Select Patents Filed for Cell-Free DNA, 2020-2023
Table 105: Patent Activity on Cancer Biomarkers, by Country/Region, January 2010-December 2020
Table 106: List of Select Patents Filed for Cancer Biomarkers, 2020-2023
Table 107: Status of NGS-Based Liquid Biopsy Patent Disputes, 2023
Table 108: Global Market Ranking, 2022
Table 109: Agilent Technologies Inc.: Company Snapshot
Table 110: Agilent Technologies Inc.: Financial Performance, 2021 and 2022
Table 111: BGI Genomics Co. Ltd: Company Snapshot
Table 112: Illumina Inc.: Company Snapshot
Table 113: Illumina Inc.: Financial Performance, 2021 and 2022
Table 114: Qiagen: Company Snapshot
Table 115: Qiagen NV: Financial Performance, 2021 and 2022
Table 116: Thermo Fisher Scientific Inc.: Company Snapshot
Table 117: Thermo Fisher Scientific Inc.: Financial Performance, 2021 and 2022
Table 118: AccuraGen Holdings: Company Snapshot
Table 119: Adaptive Biotechnologies.: Company Snapshot
Table 120: Alcen: Company Snapshot
Table 121: Ambry Genetics: Company Snapshot
Table 122: Amoy Diagnostics Co. Ltd.: Company Snapshot
Table 123: Angle Plc: Company Snapshot
Table 124: Apostle Sciences: Company Snapshot
Table 125: Arcedi Biotech ApS: Company Snapshot
Table 126: Armonica Technologies Inc.: Company Snapshot
Table 127: Arup Laboratories: Company Snapshot
Table 128: Asuragen Inc.: Company Snapshot
Table 129: Baylor Genetics: Company Snapshot
Table 130: BD: Company Snapshot
Table 131: Berry Genomics Beijing: Company Snapshot
Table 132: Biocaptiva Ltd.: Company Snapshot
Table 133: Biocept Inc.: Company Snapshot
Table 134: Biodesix: Company Snapshot
Table 135: BioFluidica: Company Snapshot
Table 136: Biolidics Ltd.: Company Snapshot
Table 137: Biological Dynamics: Company Snapshot
Table 138: biomodal: Company Snapshot
Table 139: Bionano Genomics: Company Snapshot
Table 140: Bio-Rad Laboratories Inc: Company Snapshot
Table 141: Bio-Techne: Company Snapshot
Table 142: C2i Genomics: Company Snapshot
Table 143: Capio Biosciences: Company Snapshot
Table 144: CareDx Inc.: Company Snapshot
Table 145: Caris Life Sciences: Company Snapshot
Table 146: CeGaT GmbH: Company Snapshot
Table 147: Cell Microsystems: Company Snapshot
Table 148: Centrillion Technologies: Company Snapshot
Table 149: Claret Bioscience: Company Snapshot
Table 150: ClearNote Health: Company Snapshot
Table 151: ClearNote Health: Company Snapshot
Table 152: Cyclomics: Company Snapshot
Table 153: Cygnus Biosciences Co. Ltd: Company Snapshot
Table 154: Danaher: Company Snapshot
Table 155: Dante Labs: Company Snapshot
Table 156: Datar Cancer Genetics: Company Snapshot
Table 157: Delfi Diagnostics: Company Snapshot
Table 158: DiaCarta: Company Snapshot
Table 159: Diagnologix LLC: Company Snapshot
Table 160: Diagnomics Inc.: Company Snapshot
Table 161: Diamir Bio: Company Snapshot
Table 162: DNAlytics: Company Snapshot
Table 163: DNAnexus, Inc.: Company Snapshot
Table 164: EarlyDiagnostics: Company Snapshot
Table 165: Eone Diagnomics Genome Center Co. Ltd: Company Snapshot
Table 166: Epic Sciences: Company Snapshot
Table 167: Epigenomics AG: Company Snapshot
Table 168: Eurofins Genomics: Company Snapshot
Table 169: Everly Health Inc.: Company Snapshot
Table 170: Exact Sciences Corp.: Company Snapshot
Table 171: Exopert: Company Snapshot
Table 172: Exosomics Inc.: Company Snapshot
Table 173: EZlife Bio: Company Snapshot
Table 174: Fabric Genomics Inc.: Company Snapshot
Table 175: F. Hoffmann-La Roche Ltd: Company Snapshot
Table 176: Fluxion Biosciences Inc.: Company Snapshot
Table 177: Freenome Holdings Inc.: Company Snapshot
Table 178: Fulgent Genetics: Company Snapshot
Table 179: Full Genomes Corp.: Company Snapshot
Table 180: Gene by Gene Inc.: Company Snapshot
Table 181: GeneDx LLC: Company Snapshot
Table 182: Geneseq Biosciences: Company Snapshot
Table 183: GenomOncology LLC: Company Snapshot
Table 184: GenoSaber: Company Snapshot
Table 185: Grail Inc.: Company Snapshot
Table 186: Guardant Health: Company Snapshot
Table 187: Helio Genomics: Company Snapshot
Table 188: Helix Inc.: Company Snapshot
Table 189: HTG Molecular Diagnostics Inc.: Company Snapshot
Table 190: Imagia Canexia Health: Company Snapshot
Table 191: IncellDx: Company Snapshot
Table 192: Inex Innovate Private Ltd.: Company Snapshot
Table 193: INOVIQ: Company Snapshot
Table 194: Interpace Biosciences Inc.: Company Snapshot
Table 195: Invitae Corp.: Company Snapshot
Table 196: Invivoscribe Inc.: Company Snapshot
Table 197: Jabrehoo Med Tech Co. Ltd.: Company Snapshot
Table 198: JBS Science: Company Snapshot
Table 199: Jumpcode Genomics Inc.: Company Snapshot
Table 200: Koninklijke Philips N.V.: Company Snapshot
Table 201: Labgenomics: Company Snapshot
Table 202: Laboratory Corporation of America Holdings: Company Snapshot
Table 203: Liquid Biopsy Labs: Company Snapshot
Table 204: Lucence Health Inc.: Company Snapshot
Table 205: LungLife AI: Company Snapshot
Table 206: Macrogen Inc.: Company Snapshot
Table 207: MapmyGenome: Company Snapshot
Table 208: mdxhealth: Company Snapshot
Table 209: MedGenome: Company Snapshot
Table 210: Medicover Genetics: Company Snapshot
Table 211: Menarini Silicon Biosystems: Company Snapshot
Table 212: Merck KGaA: Company Snapshot
Table 213: MiCareo Inc.: Company Snapshot
Table 214: Micronoma INC.: Company Snapshot
Table 215: miR Scientific: Company Snapshot
Table 216: MutantDx: Company Snapshot
Table 217: Myriad Genetics, Inc.: Company Snapshot
Table 218: NanoString Technologies Inc.: Company Snapshot
Table 219: Natera Inc.: Company Snapshot
Table 220: Nebula Genomics Inc.: Company Snapshot
Table 221: NeoGenomics Laboratories: Company Snapshot
Table 222: New England Biolabs: Company Snapshot
Table 223: New Horizon Health: Company Snapshot
Table 224: NOVIGENIX SA: Company Snapshot
Table 225: Novogene Co Ltd: Company Snapshot
Table 226: Nrichdx: Company Snapshot
Table 227: NuProbe: Company Snapshot
Table 228: NX Prenatal Inc.: Company Snapshot
Table 229: Oncimmune Holdings PLC: Company Snapshot
Table 230: OncoCyte Corp.: Company Snapshot
Table 231: OncoDNA: Company Snapshot
Table 232: OPKO Health Inc.: Company Snapshot
Table 233: Orchid: Company Snapshot
Table 234: Oxford Nanopore Technologies plc: Company Snapshot
Table 235: PacBio: Company Snapshot
Table 236: Pangaea Oncology: Company Snapshot
Table 237: Personal Genome Diagnostics Inc: Company Snapshot
Table 238: Personalis Inc.: Company Snapshot
Table 239: Phase Scientific: Company Snapshot
Table 240: PierianDx: Company Snapshot
Table 241: Predicine: Company Snapshot
Table 242: Prenetics Ltd.: Company Snapshot
Table 243: QCDx: Company Snapshot
Table 244: Quantapore: Company Snapshot
Table 245: Quantgene Inc.: Company Snapshot
Table 246: QuantuMDx Group Ltd.: Company Snapshot
Table 247: Quest Diagnostics: Company Snapshot
Table 248: Rarecells Inc.: Company Snapshot
Table 249: Ravgen.: Company Snapshot
Table 250: Real Time Genomics.: Company Snapshot
Table 251: Resolution Bioscience Inc.: Company Snapshot
Table 252: SAGA Diagnostics.: Company Snapshot
Table 253: Sano Genetics: Company Snapshot
Table 254: ScreenCell: Company Snapshot
Table 255: SeekIn Inc.: Company Snapshot
Table 256: Sequencing.Com: Company Snapshot
Table 257: Seven Bridges Genomics: Company Snapshot
Table 258: Single Technologies AB: Company Snapshot
Table 259: SmartCatch: Company Snapshot
Table 260: StageZero Life Sciences. Ltd.: Company Snapshot
Table 261: Strand: Company Snapshot
Table 262: Strata Oncology Inc.: Company Snapshot
Table 263: Syapse Inc.: Company Snapshot
Table 264: Sysmex Inostics Inc.: Company Snapshot
Table 265: Takara Bio Inc: Company Snapshot
Table 266: Telexos GmbH: Company Snapshot
Table 267: TwinStrand Biosciences Inc.: Company Snapshot
Table 268: Twist Bioscience: Company Snapshot
Table 269: Unchained Labs: Company Snapshot
Table 270: Universal DX: Company Snapshot
Table 271: Vela Diagnostics: Company Snapshot
Table 272: Veracyte Inc.: Company Snapshot
Table 273: VolitionRx Ltd.: Company Snapshot
Table 274: Vortex Biosciences: Company Snapshot
Table 275: Yourgene Health: Company Snapshot
Table 276: Yikon Genomics: Company Snapshot
List of Figures
Summary Figure: Global Market for Clinical Applications of Next-Generation Sequencing, by Disease Class, 2020-2028
Figure 1: Timeline of the Advancement of Sequencing Technology
Figure 2: How A Strong ESG Proposition Benefits Businesses
Figure 3: The Ten Business Sustainability Trends Identified for 2022
Figure 4: ESG-Adoption Level Across All the Industries, 2021 and 2022
Figure 5: Key Sustainable Practices Being Implemented in Research Laboratories
Figure 6: Agilent Technologies Inc.: Financial Performance, 2021 and 2022
Figure 7: Agilent Technologies Inc.: Revenue Share, by Business Unit, 2022
Figure 8: Agilent Technologies Inc.: Revenue Share, by Region, 2022
Figure 9: Illumina Inc: Financial Performance, 2021 and 2022
Figure 10: Illumina Inc.: Revenue Share, by Business Unit, 2022
Figure 11: Illumina Inc.: Revenue Share, by Country/Region, 2022
Figure 12: Qiagen NV: Financial Performance, 2021 and 2022
Figure 13: Qiagen NV: Revenue Share, by Business Unit, 2022
Figure 14: Qiagen NV: Revenue Share, by Region, 2022
Figure 15: Thermo Fisher Scientific Inc.: Financial Performance, 2021 and 2022
Figure 16: Thermo Fisher Scientific Inc.: Revenue Share, by Business Unit, 2022
Figure 17: Thermo Fisher Scientific Inc.: Revenue Share, by Region, 2022

Executive Summary

Since NGS platforms can sequence an entire genomic region or even an entire genome, a single test can examine hundreds or thousands of clinically important genetic variations. This means that one test can replace multiple conventional single-gene tests, providing an advantage in price and in the amount of precious sample needed for the test itself.

NGS is often more accurate and reliable than existing diagnostics. This can result in better clinical outcomes. For example, NGS can increase the pregnancy success rates in in vitro fertilization applications. Also, in rare genetic diseases, NGS can increase the success rates for determining a molecular diagnosis.

The NGS platform enables companies to expand the menu of disorders/diseases over time after initial launch of a test. This strategy has been employed in reproductive health applications, for example, launching a test to initially screen for aneuploidies, and then later expanding the test to include screening for additional genetic variants.

These features of NGS platforms provide a solid basis for the use of this technology in the clinic.

Companies Mentioned

  • Agilent Technologies Inc.
  • Bgi Genomics Co. Ltd
  • Illumina Inc.
  • Qiagen
  • Thermo Fisher Scientific Inc.
  • Accuragen Holdings
  • Adaptive Biotechnologies
  • Alcen
  • Ambry Genetics
  • Amoy Diagnostics Co. Ltd.
  • Angle Plc
  • Apostle Sciences
  • Arcedi Biotech Aps
  • Armonica Technologies Inc.
  • Arup Laboratories
  • Asuragen Inc.
  • Baylor Genetics
  • Becton, Dickinson And Co.
  • Berry Genomics Beijing
  • Biocaptiva Ltd.
  • Biocept Inc.
  • Biodesix
  • Biofluidica
  • Biolidics Ltd
  • Biological Dynamics
  • Biomodal
  • Bionano Genomics
  • Bio-Rad Laboratories Inc.
  • Bio-Techne
  • C2I Genomics
  • Capio Biosciences
  • Caredx Inc.
  • Caris Life Science
  • Cegat Gmbh
  • Cell Microsystems
  • Centrillion Genomics Technologies
  • Claret Bioscience
  • Clear Note Health
  • Clinical Genomics Technologies
  • Cyclomics
  • Cygnus Biosciences Co. Ltd.
  • Danaher
  • Dante Labs
  • Datar Cancer Genetics Ltd.
  • Delfi Diagnostics
  • Diacarta
  • Diagnologix Llc
  • Diagnomics Inc.
  • Diamir Bio
  • Dnalytics
  • Dnanexus Inc.
  • Earlydiagnostics
  • Eone-Diagnomics Genome Center Co. Ltd.
  • Epic Sciences
  • Epigenomics Ag
  • Eurofins Genomics
  • Everly Health Inc.
  • Exact Sciences Corp.
  • Exopert
  • Exosomics Inc.
  • Ezlife Bio
  • Fabric Genomics Inc.
  • F. Hoffmann-La Roche Ltd
  • Fluxion Biosciences Inc.
  • Freenome Holdings Inc.
  • Fulgent Genetics
  • Full Genomes Corp.
  • Gene By Gene Ltd.
  • Genedx Llc
  • Geneseq Biosciences
  • Genomoncology Llc
  • Genosaber
  • Grail Inc.
  • Guardant Health
  • Helio Genomics
  • Helix Inc.
  • Htg Molecular Diagnostics Inc.
  • Imagia Canexia Health
  • Incelldx Inc.
  • Inex Innovate Private Ltd
  • Inoviq
  • Interpace Biosciences Inc.
  • Invitae Corp.
  • Invivoscribe Inc.
  • Jabrehoo Med Tech Co. Ltd.
  • Jbs Science
  • Jumpcode Genomics Inc.
  • Koninklijke Philips N.V.
  • Labgenomics Co. Ltd.
  • Laboratory Corporation Of America Holdings
  • Liquid Biopsy Labs
  • Lucence Health Inc.
  • Lunglife Ai Inc.
  • Macrogen Inc.
  • Mapmygenome
  • Mdxhealth Inc.
  • Medgenome
  • Medicover Genetics
  • Menarini Silicon Biosystems Spa
  • Merck Kgaa
  • Micareo Rare Cell Diagnostics
  • Micronoma Inc.
  • Mir Scientific
  • Mutantdx
  • Myriad Genetics Inc.
  • Nanostring Technologies Inc.
  • Natera Inc.
  • Nebula Genomics
  • Neogenomics Laboratories
  • New England Biolabs
  • New Horizon Health Ltd.
  • Novigenix Sa
  • Novogene Co. Ltd.
  • Nrichdx Inc.
  • Nuprobe Inc.
  • Nx Prenatal Inc.
  • Oncimmune Holdings Plc
  • Oncocyte Corp.
  • Oncodna
  • Opko Health
  • Orchid
  • Oxford Nanopore Technologies Ltd.
  • Pacific Biosciences Of California Inc.
  • Pangaea Oncology
  • Personal Genome Diagnostics Inc.
  • Personalis Inc.
  • Phase Scientific
  • Pieriandx
  • Predicine
  • Prenetics Group
  • Qcdx Llc
  • Quantapore
  • Quantgene Inc.
  • Quantumdx
  • Quest Diagnostics
  • Rarecells Inc.
  • Ravgen
  • Real Time Genomics
  • Resolution Bioscience Inc.
  • Saga Diagnostics Ab
  • Sano Genetics
  • Screencell
  • Seekin Inc.
  • Sequencing.Com
  • Seven Bridges Genomics Inc.
  • Single Technologies
  • Smartcatch
  • Stagezero Life Sciences. Ltd.
  • Strand
  • Strata Oncology
  • Syapse Inc.
  • Sysmex Inostics Gmbh
  • Takara Bio Inc.
  • Telexos Gmbh
  • Twinstrand Biosciences Inc.
  • Twist Bioscience
  • Unchained Labs
  • Universal Dx
  • Vela Diagnostics
  • Veracyte
  • Volitionrx
  • Vortex Biosciences
  • Yourgene Health
  • Yikon Genomics Co. Ltd.

Table Information