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Acute Respiratory Distress Syndrome (ARDS) - Market Insights, Epidemiology and Market Forecast - 2030

  • ID: 4330677
  • Drug Pipelines
  • July 2020
  • Region: Global
  • 237 pages
  • DelveInsight
1 of 3

FEATURED COMPANIES

  • Alexion Pharmaceuticals
  • Bioxytran Inc.
  • Faron Pharmaceuticals
  • Implicit Bioscience
  • Medicinova Inc.
  • Noveome Biotherapeutics
  • MORE
‘Acute Respiratory Distress Syndrome (ARDS) - Market Insights, Epidemiology and Market Forecast - 2030' report delivers an in-depth understanding of the Acute Respiratory Distress Syndrome (ARDS), historical and forecasted epidemiology as well as the Acute Respiratory Distress Syndrome (ARDS) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Acute Respiratory Distress Syndrome (ARDS) market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Acute Respiratory Distress Syndrome (ARDS) market size from 2017 to 2030. The report also covers current Acute Respiratory Distress Syndrome (ARDS) treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assess the underlying potential of the market.

Geography Covered
  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan
Study Period: 2017-2030

Acute Respiratory Distress Syndrome (ARDS) Disease Understanding and Treatment Algorithm

Acute Respiratory Distress Syndrome (ARDS) Overview

Acute respiratory distress syndrome (ARDS) is a rapidly progressive disease occurring in critically ill patients. The main complication in ARDS is that fluid leaks into the lungs, making breathing difficult or impossible. Acute lung injury (ALI) is a common condition characterized by acute severe hypoxia that is not due to left atrial hypertension. The term ALI encompasses a continuum of clinical and radiographic changes that affect the lungs with the acute respiratory distress syndrome (ARDS) representing the more severe end of this continuum. Despite advances in the understanding of the pathophysiology and management of ALI, it is still associated with high mortality.

The causes of ARDS are divided into two categories: direct or indirect injuries to the lung. Some of the direct injuries to the lung include pneumonia, aspiration, trauma, and others whereas the indirect injuries to the lung include inflammation of the pancreas, severe infection (also known as sepsis), blood transfusions, burns, and medication reactions. The few symptoms of ARDS are shortness of breath, cough, and fever. In some cases, those with ARDS also have fast heart rates and rapid breathing. Occasionally, patients of ARDS experience chest pain, especially during inhalation. Some patients also experience bluish coloring of nails and lips due to the severely decreased oxygen levels in the blood. There are several risks factors that may escalate the risk for ARDS; this involves obesity, alcohol abuse, chemotherapy, low-protein in blood.

Acute Respiratory Distress Syndrome (ARDS) Diagnosis

The diagnosis of Acute Respiratory Distress Syndrome (ARDS) is based on the identification of characteristic symptoms, a detailed patient history, a thorough clinical evaluation and a variety of specialized tests.

ARDS is characterized by an acute, diffuse, inflammatory lung injury, leading to increased alveolar-capillary permeability, increased lung weight, and loss of aerated lung tissue. Clinically, this establishes as hypoxemia, with bilateral opacities on chest radiography, associated with reduced lung compliance and increased venous admixture and physiological dead space. Morphologically, diffuse alveolar damage is observed in the acute phase of ARDS.

Acute Respiratory Distress Syndrome (ARDS) Treatment

The Acute Respiratory Distress Syndrome (ARDS), a life-threatening condition, was described as a form of respiratory failure that closely resembled respiratory distress syndrome in infants. This can be caused by a variety of pulmonary (such as pneumonia, aspiration) or non-pulmonary (like sepsis, pancreatitis, and trauma) abuses, leading to the development of non-hydrostatic pulmonary edema. The treatment of ARDS involves general supportive measures, ventilator strategies, and appropriate treatment of the underlying condition. Besides general supportive measures, pharmacological interventions are commonly considered throughout ARDS. Although research involving the investigation of drug candidates is being carried out for over a decade, only a few pharmacological therapies have emerged for ARDS.

Despite decades of research, treatment options for ARDS are restricted. Supportive care with mechanical ventilation remains the mainstay of management. There are relatively few treatments available for ARDS. Other treatment options, which the patients with ARDS are generally subjected include supplemental oxygen, prone positioning, use of paralytics, fluid management, and a technique called positive end-expiratory pressure (PEEP) to help push the fluid out of air sacs. These are combined with continuing treatment of the original illness or injury. Because people with ARDS are less able to fight lung infections, they may develop bacterial pneumonia during the illness. Antibiotics are given to fight infection. Also, supportive treatment, such as intravenous fluid or food, may be needed.

It covers the details of conventional and current medical therapies available in the Acute Respiratory Distress Syndrome (ARDS) market for the treatment of the various types of Acute Respiratory Distress Syndrome (ARDS). It also provides the treatment guidelines and algorithms of the United States and Europe. The Acute Respiratory Distress Syndrome (ARDS) market report gives a thorough understanding of Acute Respiratory Distress Syndrome (ARDS) by including details such as disease definition, causes, risk factors, pathogenesis, and diagnosis.

Acute Respiratory Distress Syndrome (ARDS) Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Incident Population of ARDS, Severity-specific Incidence of ARDS and Incidence of ARDS by Risk Factors scenario of Acute Respiratory Distress Syndrome (ARDS) in the 7MM market covering the United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom) and Japan from 2017 to 2030.

Key Findings

This section provides glimpses of the Acute Respiratory Distress Syndrome (ARDS) epidemiology in the 7MM.
  • In the 7MM, the total incident population of ARDS is estimated to be 7,99,872 in 2017.
  • Generally, the highest number of incident cases were assessed for ARDS due to Pneumonia, in all the 7MM countries, except the United Kingdom, in which Sepsis was the primary risk factor for ARDS.
  • The estimates show a higher incidence of ARDS in the United States with 4, 95,655 cases in 2017
Country Wise-Acute Respiratory Distress Syndrome (ARDS) Epidemiology

The epidemiology segment also provides the Acute Respiratory Distress Syndrome (ARDS) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Acute Respiratory Distress Syndrome (ARDS) Drug Chapters

The drug chapter segment of the Acute Respiratory Distress Syndrome (ARDS) report encloses the detailed analysis of Acute Respiratory Distress Syndrome (ARDS) marketed drugs and mid- and late-stage pipeline drugs. It also helps to understand the Acute Respiratory Distress Syndrome (ARDS) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.

Acute Respiratory Distress Syndrome (ARDS) Emerging Drugs

Traumakine: Faron Pharmaceuticals

Interferon-beta-1a - also known as Traumakine; FP-1201-lyo; MR11A8; FP-1201; Recombinant Human IFN Beta-1a - is under development by Faron Pharmaceuticals as its lead drug candidate. It is a lyophilized powder form of recombinant human IFN beta-1a reconstituted in water for injection. It is administered intravenously, and targets the Interferon-beta receptor 1, activating its action. In January 2018, Faron Pharmaceuticals received Fast Track designation from the US Food and Drug Administration (FDA) for Traumakine, for the treatment of ARDS. The drug is in phase III (CALIBER Global Study) clinical developmental trial for the patients with ARDS.

Product detail in the report.

BIO-11006: BioMarck Pharmaceuticals

BioMarck Pharmaceuticals is developing its lead compound BIO-11006 under the Phase II stage of development for the treatment of Adult Respiratory Distress Syndrome (ARDS). Biomarck's BIO-11006 is a novel, highly soluble, patented, 10 amino acid peptides. It acts as a MARCKS (Myristoylated alanine-rich C kinase substrate) protein inhibitor and is being developed to specifically target the MARCKS protein to inhibit cancer cell division and movement. Furthermore, it is a water-soluble, stable aerosolized anti-MARCKS peptide inhalation solution that involves aerosolized delivery of either the active drug or placebo by the “Aeroneb Pro nebulizer.”

Product detail in the report.

MultiStem: Athersys

MultiStem - also known as AMI MultiStem; HLCM 051 and PF-05285401 - is a patented regenerative product which can promote tissue repair and healing in a variety of ways, such as through the production of multiple therapeutic factors produced in response to signals of inflammation and tissue damage and restore immune system balance. MultiStem is under development by Athersys and is currently in the Phase II stage for the treatment of Acute Respiratory Distress Syndrome. Currently, the US FDA granted Fast Track designation to Athersys for its clinical program evaluating MultiStem cell therapy for the treatment of ARDS.

Product detail in the report.

Solnatide: Apeptico Forschung und Entwicklung GmbH

Solnatide (AP301; synonym to TNF-derived TIP-peptide) under development by Apeptico Forschung und Entwicklung GmbH is a synthetic molecule whose structure bases on the lectin-like domain of the Human Tumor Necrosis Factor α. The AP301 peptide is water-soluble and can be administered into the lung by oral inhalation. The drug is conducting phase II clinical developmental trial in patients with ARDS.

Product detail in the report.

Acute Respiratory Distress Syndrome (ARDS) Market Outlook

Despite recent advances in critical care, the mortality due to ARDS varies from 35% to 45% in various studies. The mortality has been reported to be associated with organ failure, sepsis, age, and associated comorbid illness. The treatment of ARDS involves general supportive measures, ventilator strategies, and appropriate treatment of the underlying condition. Besides general supportive measures, pharmacological interventions are commonly considered throughout ARDS. Although research involving the investigation of drug candidates is being carried out for over a decade, only a few pharmacological therapies have emerged for ARDS. In the off-label treatment options, STATIN therapy, NMBAs, and glucocorticosteroids are recommended because there is no approved therapy for this indication yet.

The Acute Respiratory Distress Syndrome (ARDS) market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Acute Respiratory Distress Syndrome (ARDS) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers, and demand of better technology.

This segment gives a thorough detail of Acute Respiratory Distress Syndrome (ARDS) market trend of each late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to the publisher, Acute Respiratory Distress Syndrome (ARDS) 7MM market is expected to change in the study period 2017-2030.

Key Findings

This section includes a glimpse of the Acute Respiratory Distress Syndrome (ARDS) 7MM market.
  • According to the publisher estimates, the United States accounts for the largest market size of Acute Respiratory Distress Syndrome (ARDS), in comparison to Japan and EU5 (Germany, Italy, France, UK and Spain).
  • The market size of Acute Respiratory Distress Syndrome (ARDS) in the seven major markets is USD 3,007.1 Million in 2017.
  • Expected launch of potential therapies may increase the market size in the coming years, assisted by an increase in the incident population of ARDS and awareness of the disease.
The United States Market Outlook

This section provides the total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in the United States.

EU-5 Market Outlook

The total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

Japan Market Outlook

The total Acute Respiratory Distress Syndrome (ARDS) market size and market size by therapies in Japan are provided.

Acute Respiratory Distress Syndrome (ARDS) Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the Acute Respiratory Distress Syndrome (ARDS) market or expected to get launched in the market during the study period 2017-2030. The analysis covers Acute Respiratory Distress Syndrome (ARDS) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Acute Respiratory Distress Syndrome (ARDS) Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing and patent details for Acute Respiratory Distress Syndrome (ARDS) emerging therapies.

Competitive Intelligence Analysis

The publisher performs competitive and market intelligence analysis of the Acute Respiratory Distress Syndrome (ARDS) market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report
  • The report covers the descriptive overview of Acute Respiratory Distress Syndrome (ARDS), explaining its causes, signs and symptoms, pathogenesis and currently available therapies.
  • Comprehensive insight has been provided into the Acute Respiratory Distress Syndrome (ARDS) epidemiology and treatment.
  • Additionally, an all-inclusive account of both the current and emerging therapies for Acute Respiratory Distress Syndrome (ARDS) are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
  • A detailed review of Acute Respiratory Distress Syndrome (ARDS) market; historical and forecasted is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM Acute Respiratory Distress Syndrome (ARDS) market.
Report Highlights
  • Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the 7MM is anticipated to rise at a CAGR of 1.07%.
  • The market for ARDS in the 7MM is projected to rise at a CAGR of 9.55% during the study period (2017-2030).
  • Dynamic research and developmental activity with 60+ companies in the pipeline at different stages.
  • In the coming years, Acute Respiratory Distress Syndrome (ARDS) market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies and academics are working to assess challenges and seek opportunities that could influence Acute Respiratory Distress Syndrome (ARDS) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
  • Major players are involved in developing therapies for Acute Respiratory Distress Syndrome (ARDS). Launch of emerging therapies will significantly impact the Acute Respiratory Distress Syndrome (ARDS) market.
  • The in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.
Acute Respiratory Distress Syndrome (ARDS) Report Insights
  • Patient Population
  • Therapeutic Approaches
  • Acute Respiratory Distress Syndrome (ARDS) Pipeline Analysis
  • Acute Respiratory Distress Syndrome (ARDS) Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies
Acute Respiratory Distress Syndrome (ARDS) Report Key Strengths
  • Eleven Years Forecast
  • 7MM Coverage
  • Acute Respiratory Distress Syndrome (ARDS) Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake
Acute Respiratory Distress Syndrome (ARDS) Report Assessment
  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers
Key Questions Answered

Market Insights:
  • What was the Acute Respiratory Distress Syndrome (ARDS) market share (%) distribution in 2017 and how it would look like in 2030?
  • What would be the Acute Respiratory Distress Syndrome (ARDS) total market size as well as market size by therapies across the 7MM during the forecast period (2020-2030)?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest Acute Respiratory Distress Syndrome (ARDS) market size during the forecast period (2020-2030)?
  • At what CAGR, the Acute Respiratory Distress Syndrome (ARDS) market is expected to grow at the 7MM level during the forecast period (2020-2030)?
  • What would be the Acute Respiratory Distress Syndrome (ARDS) market outlook across the 7MM during the forecast period (2020-2030)?
  • What would be the Acute Respiratory Distress Syndrome (ARDS) market growth till 2030, and what will be the resultant market size in the year 2030?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?
Epidemiology Insights:
  • What is the disease risk, burden and unmet needs of Acute Respiratory Distress Syndrome (ARDS)?
  • What is the historical Acute Respiratory Distress Syndrome (ARDS) patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
  • What would be the forecasted patient pool of Acute Respiratory Distress Syndrome (ARDS) at the 7MM level?
  • What will be the growth opportunities across the 7MM for the patient population pertaining to ARDS?
  • Out of the countries mentioned above, which country would have the highest prevalent population of Acute Respiratory Distress Syndrome (ARDS) during the forecast period (2020-2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2020-2030)?
Current Treatment Scenario, Marketed Drugs and Emerging Therapies:
  • What are the current options for the treatment of Acute Respiratory Distress Syndrome (ARDS) along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Acute Respiratory Distress Syndrome (ARDS) in the US and Europe?
  • What are the Acute Respiratory Distress Syndrome (ARDS) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Acute Respiratory Distress Syndrome (ARDS)?
  • How many therapies are developed by each company for the treatment of Acute Respiratory Distress Syndrome (ARDS)?
  • How many emerging therapies are in the mid-stage and late-stage of development for the treatment of Acute Respiratory Distress Syndrome (ARDS)?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Acute Respiratory Distress Syndrome (ARDS) therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Acute Respiratory Distress Syndrome (ARDS) and their status?
  • What are the key designations that have been granted for the emerging therapies for Acute Respiratory Distress Syndrome (ARDS)?
  • What are the 7MM historical and forecasted market of Acute Respiratory Distress Syndrome (ARDS)?
Reasons to Buy
  • The report will help in developing business strategies by understanding trends shaping and driving the Acute Respiratory Distress Syndrome (ARDS).
  • To understand the future market competition in the ARDS market and Insightful review of the key market drivers and barriers.
  • Organize sales and marketing efforts by identifying the best opportunities for Acute Respiratory Distress Syndrome (ARDS) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
  • Organize sales and marketing efforts by identifying the best opportunities for Acute Respiratory Distress Syndrome (ARDS) market.
  • To understand the future market competition in the Acute Respiratory Distress Syndrome (ARDS) market.
Note: Product cover images may vary from those shown
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FEATURED COMPANIES

  • Alexion Pharmaceuticals
  • Bioxytran Inc.
  • Faron Pharmaceuticals
  • Implicit Bioscience
  • Medicinova Inc.
  • Noveome Biotherapeutics
  • MORE
1 Key Insights

2 Executive Summary

3 SWOT Analysis

4 Acute Respiratory Distress Syndrome (ARDS): Market Overview at a Glance
4.1 Total Market Share (%) Distribution of ARDS in 2017
4.2 Total Market Share (%) Distribution of ARDS in 2030

5 Acute Respiratory Distress Syndrome (ARDS): Disease Background and Overview
5.1 Introduction
5.1.1 Consensus Definitions of Acute Lung Injury and Acute Respiratory Distress Syndrome (ARDS)
5.1.2 Development of Berlin Definition of ARDS
5.1.3 Problems with the AECC definition and subsequent Berlin definition of acute respiratory distress syndrome (ARDS)
5.2 Causes and Risk Factors
5.2.1 Risk Factors of Acute Respiratory Distress Syndrome (ARDS)
5.3 Pathophysiology of Acute Respiratory Distress Syndrome (ARDS)
5.3.1 Inflammatory Processes in ARDS
5.3.2 The initial event of injury
5.3.3 Endothelial Damage
5.3.4 Specific Mediators of Inflammation and Lung Damage in ARDS
5.3.5 Altered Pulmonary Physiology in ARDS
5.3.6 Genetics
5.4 Stages of Acute Respiratory Distress Syndrome (ARDS)
5.5 Ventilator-Induced Lung Injury (VILI)
5.6 Major Determinants of VILI
5.6.1 Ventilator determinants of VILI
5.6.2 Patient determinants of VILI
5.7 Diagnosis of Acute Respiratory Distress Syndrome (ARDS)
5.7.1 Imaging techniques in ARDS
5.7.2 Imaging findings in ARDS
5.7.3 Differential Diagnosis

6 Recognized Establishments

7 Epidemiology and Patient Population
7.1 Key Findings
7.2 Methodology

8 7MM Epidemiology Analysis
8.1 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the 7MM
8.2 Severity-specific Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the 7MM

9 United States Epidemiology
9.1 Assumptions and Rationale
9.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the United States
9.3 Severity-specific Incident Population of ARDS in the United States
9.4 Incident Population of ARDS by Risk Factors in the United States

10 EU5 Epidemiology
10.1 Germany Epidemiology
10.1.1 Assumptions and Rationale
10.1.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in Germany
10.1.3 Severity-specific Incidence of ARDS in Germany
10.1.4 Incident Population of ARDS by Risk Factors in Germany
10.2 France Epidemiology
10.2.1 Assumptions and Rationale
10.2.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS), in France
10.2.3 Severity-specific Incidence of ARDS in France
10.2.4 Incident Population of ARDS by Risk Factors in France
10.3 Italy Epidemiology
10.3.1 Assumptions and Rationale
10.3.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in Italy
10.3.3 Severity-specific Incidence of ARDS in Italy
10.3.4 Incident Population of ARDS by Risk Factors in Italy
10.4 Spain Epidemiology
10.4.1 Assumptions and Rationale
10.4.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in Spain
10.4.3 Severity-specific Incidence of ARDS in Spain
10.4.4 Incident Population of ARDS by Risk Factors in Spain
10.5 United Kingdom Epidemiology
10.5.1 Assumptions and Rationale
10.5.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS) in the United Kingdom
10.5.3 Severity-specific Incidence of ARDS in the United Kingdom
10.5.4 Incident Population of ARDS by Risk Factors in the United Kingdom

11 Japan Epidemiology
11.1 Assumptions and Rationale
11.2 Total Incident Population of Acute Respiratory Distress Syndrome (ARDS), ARDS in Japan
11.3 Severity-specific Incidence of ARDS in Japan
11.4 Incident Population of ARDS by Risk Factors in Japan

12 Treatment Algorithm, Current Treatment, and Medical Practices
12.1 Treatment and Support for Acute Respiratory Distress Syndrome (ARDS)
12.2 Treatment of ALI/ARDS associated with COVID-19

13 Proposed Guidelines for ARDS
13.1 An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome
13.2 The Clinical Practice Guideline by the Japanese Society of Respiratory Care Medicine and the Japanese Society of Intensive Care Medicine for the management of ARDS in Japan
13.3 Infectious Diseases Society of America (IDSA) Guidelines on the Treatment and Management of Patients with COVID-19
13.4 WHO guidance for the treatment ARDS associated with COVID-19

14 Unmet Needs

15 Off-Label Therapies for ARDS
15.1 Neuromuscular Blocking Agents (NMBAs)
15.1.1 Description
15.1.2 Mechanism of Action
15.1.3 Advantages and Disadvantages
15.1.4 Clinical Development
15.2 Inhaled Vasodilators
15.2.1 Description
15.2.2 Inhaled Pulmonary Vasodilators
15.2.3 Advantages and Disadvantages
15.2.4 Clinical Development
15.3 Corticosteroids
15.3.1 Description
15.3.2 Mechanism of Action
15.3.3 Advantages and Disadvantages
15.3.4 Clinical Development

16 Emerging Therapies
16.1 Key Cross Competition
16.1.1 List of Products in development for ARDS/ALI
16.2 Traumakine: Faron Pharmaceuticals
16.2.1 Product Description
16.2.2 Other Developmental Activities
16.2.3 Clinical Development
16.2.4 Clinical Trials Information
16.2.5 Safety and Efficacy
16.2.6 Product Profile
16.3 Bio-11006: BioMarck Pharmaceuticals
16.3.1 Product Description
16.3.2 Other Developmental Activities
16.3.3 Clinical Development
16.3.4 Clinical Trials Information
16.3.5 Safety and Efficacy
16.3.6 Product Profile
16.4 MultiStem: Athersys
16.4.1 Product Description
16.4.2 Other Developmental Activities
16.4.3 Clinical Development
16.4.4 Clinical Trials Information
16.4.5 Safety and Efficacy
16.4.6 Product Profile
16.5 Solnatide (AP301): APEPTICO Forschung und Entwicklung GmbH
16.5.1 Product Description
16.5.2 Other Developmental Activities
16.5.3 Clinical Development
16.5.4 Clinical Trials Information
16.5.5 Safety and Efficacy
16.5.6 Product Profile
16.6 Ultomiris (ravulizumab-cwvz): Alexion Pharma
16.6.1 Product Description
16.6.2 Other Developmental Activities
16.6.3 Clinical Development
16.6.4 Product Profile
16.7 Soliris (eculizumab): Alexion Pharma
16.7.1 Product Description
16.7.2 Other Developmental Activities
16.7.3 Clinical Development
16.7.4 Product Profile

17 Unknown Status
17.1 Ulinastatin: Techpool Bio-Pharma
17.1.1 Product Description
17.1.2 Other Developmental Activities
17.1.3 Clinical Development
17.1.4 Clinical Trials Information
17.1.5 Product Profile

18 Discontinued Products
18.1 APN01 (GSK2586881): Apeiron Biologics/GlaxoSmithKline
18.1.1 Product Description
18.1.2 Other Developmental Activities
18.1.3 Clinical Development
18.1.4 Safety and Efficacy
18.1.5 Product Profile
18.2 GSK2862277: GlaxoSmithKline
18.2.1 Product Description
18.2.2 Other Developmental Activities
18.2.3 Clinical Development
18.2.4 Safety and Efficacy
18.2.5 Product Profile
18.3 Remodulin (Treprostinil Inhalation Solution): United Therapeutics
18.3.1 Product Description
18.3.2 Other Developmental Activities
18.3.3 Clinical Development
18.3.4 Clinical Trials Information
18.3.5 Product Profile

19 Acute Respiratory Distress Syndrome (ARDS): 7MM Market Analysis
19.1 Key Findings
19.2 Market Forecast Assumptions
19.3 Market Size of ARDS in the 7MM countries
19.4 Market Size of ARDS by therapies in the 7MM

20 Attribute Analysis

21 Conjoint Analysis

22 United States: Market Outlook
22.1 United States Market Size
22.1.1 Total Market size of ARDS
22.1.2 Market Size of ARDS by Therapies in the US

23 EU-5 Countries: Market Outlook
23.1 Germany Market Size
23.1.1 Total Market Size of ARDS
23.1.2 Market Size of ARDS by Therapies in Germany
23.2 France Market Size
23.2.1 Total Market Size of ARDS
23.2.2 Market Size of ARDS by Therapies in France
23.3 Italy Market Size
23.3.1 Total Market Size of ARDS
23.3.2 Market Size of ARDS by Therapies in Italy
23.4 Spain Market Size
23.4.1 Total Market Size of ARDS
23.4.2 Market Size of ARDS by Therapies in Spain
23.5 United Kingdom Market Size
23.5.1 Total Market Size of ARDS
23.5.2 Market Size of ARDS by Therapies in the UK

24 Japan Market Outlook
24.1 Japan Market Size
24.1.1 Total Market Size of ARDS
24.1.2 Market Size of ARDS by Therapies in Japan

25 Access and Reimbursement

26 Case Reports
26.1 Coronavirus Disease 2019 (COVID-19) Complicated by Acute Respiratory Distress Syndrome: An Internist’s Perspective
26.3 A case report of severe hypothermia complicated by acute respiratory distress syndrome

27 Market Drivers

28 Market Barriers

29 Appendix

31 Report Methodology

32 Publisher Capabilities

33 Disclaimer

34 About the Publisher

List of Tables
Table 1: Definition of Acute Respiratory Distress Syndrome (ARDS)
Table 2: American European Consensus Conference Criteria for Acute Lung Injury (ALI) and the Acute Respiratory Distress Syndrome (ARDS)
Table 3: Berlin Definition of Mild, Moderate, and Severe Acute Respiratory Distress Syndrome (ARDS)
Table 4: Factors That Distinguish ARDS, CHF, and Pneumonia
Table 5: Total Incident Population of ARDS in the 7MM (2017-2030)
Table 6: Severity-specific Incident Population of ARDS in the 7MM (2017-2030)
Table 7: Total Incident Population of ARDS in the US (2017-2030)
Table 8: Severity-specific Incident Population of ARDS in the US (2017-2030)
Table 9: Incidence of ARDS by Risk Factors in the US (2017-2030)
Table 10: Total Incident Population of ARDS in Germany (2017-2030)
Table 11: Severity-specific Incident Population of ARDS in Germany (2017-2030)
Table 12: Incidence of ARDS by Risk Factors in Germany (2017-2030)
Table 13: Total Incident Population of ARDS in France (2017-2030)
Table 14: Severity-specific Incident Population of ARDS in France (2017-2030)
Table 15: Incidence of ARDS by Risk Factors in France (2017-2030)
Table 16: Total Incident Population of ARDS in Italy (2017-2030)
Table 17: Severity-specific Incident Population of ARDS in Italy (2017-2030)
Table 18: Incidence of ARDS by Risk Factors in Italy (2017-2030)
Table 19: Total Incident Population of ARDS in Spain (2017-2030)
Table 20: Severity-specific Incident Population of ARDS in Spain (2017-2030)
Table 21: Incidence of ARDS by Risk Factors in Spain (2017-2030)
Table 22: Total Incident Population of ARDS in the UK (2017-2030)
Table 23: Severity-specific Incident Population of ARDS in the UK (2017-2030)
Table 24: Incidence of ARDS by Risk Factors in the UK (2017-2030)
Table 25: Total Incident Population of ARDS in Japan (2017-2030)
Table 26: Severity-specific Incident Population of ARDS in Japan(2017-2030)
Table 27: Incidence of ARDS by Risk Factors in Japan (2017-2030)
Table 28: Management of Acute Respiratory Distress Syndrome (ARDS)
Table 29: Spontaneous Breathing Trial: Eligibility and Weaning Parameters
Table 30: Therapeutic options for severe acute respiratory distress syndrome related to coronavirus disease 2019
Table 31: Recommendations for Specific Treatment Questions for the Management of ARDS
Table 32: The Clinical Practice Guideline for The Management of ARDS in Japan
Table 33: Recommendations by the Infectious Diseases Society of America
Table 34: Randomized trials of Methylprednisolone for ARDS prevention
Table 35: Comparison of Emerging Drugs
Table 36: List of Products in development for ARDS/ALI
Table 37: Traumakine, Clinical Trial Description, 2020
Table 38: Bio-11006, Clinical Trial Description, 2020
Table 39: MultiStem, Clinical Trial Description, 2020
Table 40: Solnatide (AP301), Clinical Trial Description, 2020
Table 41: Soliris, Clinical Trial Description, 2020
Table 42: Ulinastatin, Clinical Trial Description, 2020
Table 43: APN01 (GSK2586881), Clinical Trial Description, 2020
Table 44: GSK2862277, Clinical Trial Description, 2020
Table 45: Remodulin (Treprostinil Inhalation Solution), Clinical Trial Description, 2020
Table 46: 7 Major Market Size of ARDS in the 7MM, USD Million (2017-2030)
Table 47: Market size of ARDS by therapies in the 7MM, in USD Million (2017-2030)
Table 48: Conjoint Analysis for Solnatide
Table 49: Conjoint Analysis for Multistem
Table 50: Conjoint Analysis for BIO-11006
Table 51: Conjoint Analysis for Traumakine
Table 52: United States Market Size of ARDS, USD Million (2017-2030)
Table 53: Market size of ARDS by therapies in the US, in USD Million (2017-2030)
Table 54: Germany Market Size of ARDS, USD Million (2017-2030)
Table 55: Market size of ARDS by therapies in Germany, in USD Million (2017-2030)
Table 56: France Market Size of ARDS, USD Million (2017-2030)
Table 57: Market size of ARDS by therapies in France, in USD Million (2017-2030)
Table 58: Italy Market Size of ARDS, USD Million (2017-2030)
Table 59: Market size of ARDS by therapies in Italy, in USD Million (2017-2030)
Table 60: Spain Market Size of ARDS, USD Million (2017-2030)
Table 61: Market size of ARDS by therapies in Spain, in USD Million (2017-2030)
Table 62: United Kingdom Market Size of ARDS, USD Million (2017-2030)
Table 63: Market size of ARDS by therapies in the UK, in USD Million (2017-2030)
Table 64: Japan Market Size of ARDS, USD Million (2017-2030)
Table 65: Market size of ARDS by therapies in Japan, in USD Million (2017-2030)

List of Figures
Figure 1: Acute respiratory distress syndrome (ARDS) SWOT Analysis
Figure 2: Risk factors of Acute Respiratory Distress Syndrome (ARDS)
Figure 3: A simplified model of the pathogenesis of ARDS
Figure 4: Effects of Mast Cell Activation
Figure 5: Total Incident Population of ARDS in the 7MM (2017-2030)
Figure 6: Severity specific Incident Population of ARDS in the 7MM (2017-2030)
Figure 7: Total Incident Population of ARDS in the US (2017-2030)
Figure 8: Severity-specific Incidence of ARDS in the US (2017-2030)
Figure 9: Incidence of ARDS by Risk Factors in the US (2017-2030)
Figure 10: Total Incident Population of ARDS in Germany (2017-2030)
Figure 11: Severity-specific Incidence of ARDS in Germany (2017-2030)
Figure 12: Incident Population of ARDS by Risk Factors in Germany (2017-2030)
Figure 13: Total Incident Population of ARDS in France (2017-2030)
Figure 14: Severity-specific Incidence of ARDS in France (2017-2030)
Figure 15: Incident Population of ARDS by Risk Factors in France (2017-2030)
Figure 16: Total Incident Population of ARDS in Italy (2017-2030)
Figure 17: Severity-specific Incidence of ARDS in Italy (2017-2030)
Figure 18: Age-Specific Incidence of ARDS in Italy (2017-2030)
Figure 19: Total Incident Population of ARDS in Spain (2017-2030)
Figure 20: Severity-specific Incidence of ARDS in Spain (2017-2030)
Figure 21: Incident Population of ARDS by Risk Factors in Spain (2017-2030)
Figure 22: Total Incident Population of ARDS in the UK (2017-2030)
Figure 23: Severity-specific Incidence of ARDS in the UK (2017-2030)
Figure 24: Incident Population of ARDS by Risk Factors in the UK (2017-2030)
Figure 25: Total Incident Population of ARDS in Japan (2017-2030)
Figure 26: Severity-specific Incidence of ARDS in Japan (2017-2030)
Figure 27: Incident Population of ARDS by Risk Factors in Japan (2017-2030)
Figure 28: Treatment Algorithm for ARDS
Figure 29: Unmet Needs of ARDS
Figure 30: Market Size of ARDS in the 7MM in USD Million (2017-2030)
Figure 31: Market Size of ARDS by therapies in the 7MM in USD Million (2017-2030)
Figure 32: Market Size of ARDS in the US, USD Millions (2017-2030)
Figure 33: Market Size of ARDS by therapies in the United States in USD Million (2017-2030)
Figure 34: Market Size of ARDS in Germany, USD Millions (2017-2030)
Figure 35: Market Size of ARDS by therapies in Germany in USD Million (2017-2030)
Figure 36: Market Size of ARDS in France, USD Millions (2017-2030)
Figure 37: Market Size of ARDS by therapies in France in USD Million (2017-2030)
Figure 38: Market Size of ARDS in Italy, USD Millions (2017-2030)
Figure 39: Market Size of ARDS by therapies in Italy in USD Million (2017-2030)
Figure 40: Market Size of ARDS in Spain, USD Millions (2017-2030)
Figure 41: Market Size of ARDS by therapies in Spain in USD Million (2017-2030)
Figure 42: Market Size of ARDS in the UK, USD Millions (2017-2030)
Figure 43: Market Size of ARDS by therapies in the UK in USD Million (2017-2030)
Figure 44: Market Size of ARDS in Japan, USD Millions (2017-2030)
Figure 45: Market Size of ARDS by therapies in Japan in USD Million (2017-2030)
Figure 46: Market Drivers
Figure 47: Market Barriers
Note: Product cover images may vary from those shown
3 of 3
  • Ache Laboratorios Farmaceuticos
  • Alexion Pharmaceuticals
  • Algernon Pharmaceuticals
  • Ampio Pharmaceuticals Inc.
  • Apeiron Biologics
  • Apeptico Forschung und Entwicklung GmbH
  • Aqualung Therapeutics Corp.
  • Athersys
  • aTyr Pharma
  • Bioaegis Therapeutics Inc.
  • Biohaven Pharmaceutical Holding Co. Ltd.
  • Biomarck Pharmaceuticals
  • Bioxytran Inc.
  • Caladrius Biosciences Inc.
  • Cellenkos Inc
  • Celularity Inc.; Sorrento Therapeutics Inc.; Lung Biotechnology PBC, a subsidiary of United Therapeutics Corp.
  • Cerecor Inc.
  • Cyclacel Pharmaceuticals
  • CytoDyn
  • Diffusion Pharmaceuticals Inc.; University of Virginia
  • Eli Lilly and Company
  • Faron Pharmaceuticals
  • GEn1E Lifesciences
  • Histocell, S.L.
  • Hospital to Academy of Military Medical Sciences/Ivy Institute of Stem Cells Co. Ltd
  • Humanigen, Inc.
  • Iltoo Pharma
  • Immix Biopharma Inc.
  • Implicit Bioscience
  • Kinevant Sciences GmbH/Roivant Sciences
  • Kiniksa
  • Laboratoire français de Fractionnement et de Biotechnologies
  • Lamellar Biomedical Ltd.
  • Lattice Biologics Ltd.
  • Leading Biosciences Inc.
  • Mallinckrodt /Novoteris LLC
  • Mannkind Corp.
  • Medicinova Inc.
  • Merck/Eli Lilly
  • Meridigen Biotech
  • Mesoblast Limited
  • Mylan Laboratories
  • Navigen pharmaceuticals
  • NeuroRx/Relief Therapeutics
  • Noveome Biotherapeutics
  • Noxopharm Co.
  • Pharmazz
  • Predictive Biotech, of Salt Lake City, a subsidiary of Predictive Technology Group
  • Quark Pharmaceuticals
  • Roche Pharma AG
  • Theravance Biopharma,
  • Tiziana
  • Vanda Pharmaceuticals Inc.
  • Windtree Therapeutics
  • XORTX Therapeutics
  • ZyVersa Therapeutics
Note: Product cover images may vary from those shown
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