Cancer Cachexia - Pipeline Insight, 2024

This “Cancer Cachexia - Pipeline Insight, 2024,” report provides comprehensive insights about 15+ companies and 15+ pipeline drugs in Cancer Cachexia pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

• Global coverage

Cancer Cachexia Understanding

Cancer Cachexia: Overview

Cancer cachexia is a wasting syndrome characterized by weight loss, anorexia, asthenia and anemia. The pathogenicity of this syndrome is multifactorial, due to a complex interaction of tumor and host factors. The signs and symptoms of cachexia are considered as the prognostic parameters in cancer patients. Cancer cachexia most often affects patients with cancers of the upper gastrointestinal tract, including the esophagus, stomach, and pancreas. Not all cancer patients are affected equally by cachexia. There are three stages of cachexia: Precachexia - weight loss of less than 5% of body weight, Cachexia - weight loss greater than 5% of body weight, Refractory Cachexia - refers to patients with cachexia whose cancer treatments are no longer working and have a life expectancy of less than 3 months. Drastic weight loss can be a risk factor for poor survival of a cancer diagnosis. Cachectic patients have worse outcomes with surgery, chemotherapy, and radiation therapy. Cachexia can be treated by better managing symptoms that affect appetite, including nausea, pain and constipation. Treatments can attempt to stimulate the appetite with medications like synthetic hormones and corticosteroids.

Cancer Cachexia - Pipeline Insight, 2024 report outlays comprehensive insights of present scenario and growth prospects across the indication. A detailed picture of the Cancer Cachexia pipeline landscape is provided which includes the disease overview and Cancer Cachexia treatment guidelines. The assessment part of the report embraces, in depth Cancer Cachexia commercial assessment and clinical assessment of the pipeline products under development. In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Cancer Cachexia collaborations, licensing, mergers and acquisition, funding, designations and other product related details.

Report Highlights

• The companies and academics are working to assess challenges and seek opportunities that could influence Cancer Cachexia R&D. The therapies under development are focused on novel approaches to treat/improve Cancer Cachexia.

Cancer Cachexia Emerging Drugs Chapters

This segment of the Cancer Cachexia report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Cancer Cachexia Emerging Drugs

Macimorelin: AEterna ZentarisMacimorelin (AEZS 130) is an orally active, small-molecule, being developed by AEterna Zentaris for the diagnosis of adult and pediatric growth hormone deficiency (AGHD; PGHD) [somatotropin deficiency in development table] and for the treatment of cachexia associated with chronic diseases, such as AIDS and cancer. Macimorelin was approved by the FDA in December 2017 under the market name Macrilen for oral solution. Macimorelin stimulates GH release by activating growth hormone secretagogue receptors present in the pituitary and hypothalamus. The drug is currently being investigated in Phase II clinical to treat patients with Cancer Cachexia.

PF- 06946860: PfizerPF- 06946860 is a Growth Factor Blocker being investigated in Phase I stage of development. A 6 week double blind study to compare the effects of the investigational new drug (PF-06946860) and a placebo on appetite has been initiated to find out how participants with advanced cancer and anorexia feel after receiving repeated doses injected under the skin.

Cancer Cachexia: Therapeutic Assessment

This segment of the report provides insights about the different Cancer Cachexia drugs segregated based on following parameters that define the scope of the report, such as:

Major Players in Cancer Cachexia

There are approx. 15+ key companies which are developing the therapies for Cancer Cachexia. The companies which have their Cancer Cachexia drug candidates in the most advanced stage, i.e. Phase II include, AEterna Zentaris.

Phases

This report covers around 15+ products under different phases of clinical development like

• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Route of Administration

Cancer Cachexia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

• Oral
• Parenteral
• Intravenous
• Subcutaneous
• Topical

Molecule Type

Products have been categorized under various Molecule types such as

• Monoclonal Antibody
• Peptides
• Polymer
• Small molecule
• Gene therapy

Product Type

Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Cancer Cachexia: Pipeline Development Activities

The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Cancer Cachexia therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Cancer Cachexia drugs.

Cancer Cachexia Report Insights

• Cancer Cachexia Pipeline Analysis
• Therapeutic Assessment
• Unmet Needs
• Impact of Drugs

Cancer Cachexia Report Assessment

• Pipeline Product Profiles
• Therapeutic Assessment
• Pipeline Assessment
• Inactive drugs assessment
• Unmet Needs

Key Questions

Current Treatment Scenario and Emerging Therapies:

• How many companies are developing Cancer Cachexia drugs?
• How many Cancer Cachexia drugs are developed by each company?
• How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Cancer Cachexia?
• What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Cancer Cachexia therapeutics?
• What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
• What are the clinical studies going on for Cancer Cachexia and their status?
• What are the key designations that have been granted to the emerging drugs?

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