Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellular mechanisms, and the importance of environmental context and evolution. This new edition incorporates critical advances in the field, also including increased coverage of hormonal influences on food intake, and on the cardiovascular system.
The addition of entirely new principles provides further coverage of epigenetics and appetite. Thoroughly revised and updated, this book is an ideal resource for neuroscientists and researchers engaging in this rapidly expanding field of study.
- Provides a unique structure where each chapter addresses a key principle that is illustrated by numerous basic experimental and clinical examples
- Includes user-friendly features, such as boxed figures with extended captions and references, numerous clinical notes, and a comprehensive list of abbreviations
- Contains numerous illustrations that highlight both the clinical and basic science information
Section I: Characterizing the Phenomena: Hormone Effects are Strong and Reliable 1. Hormones Can Both Facilitate and Repress Behavioral Responses 2. One Hormone Can have Many Effects: A Single Hormone Can Affect Complex Behaviors 3. Hormone Combinations Can be Important for Influencing an Individual Behavior 4. Hormone Metabolites Can be the Behaviorally Active Compounds 5. There are Optimal Hormone Concentrations: Too Much or Too Little Can be Damaging 6. Hormones Do Not ''Cause'' Behavior; They Alter Probabilities of Responses to Given Stimuli
Section II: History: Hormone Effects Can Depend on Family, Gender, and Development 7. Familial/Genetic Dispositions to Hormone Responsiveness Can Influence Behavior 8. The Sex of the Recipient can Influence the Behavioral Response 9. Hormone Actions Early in Development Can Influence Hormone Responsiveness in the CNS During Adulthood 10. Puberty Alters Hormone Secretion and Hormone Responsivity and Heralds Sex Differences 11. Changes in Hormone Levels and Responsiveness During Aging Affect Behavior
Section III: Time: Hormonal Effects on Behavior Depend on Temporal Parameters 12. Duration of Hormone Exposure Can Make a Big Difference: In Some Cases Longer is Better; In Other Cases Brief Pulses are Optimal for Behavioral Effects 13. Hormonal Secretions and Responses are Affected by Biological Clocks
Section IV: Space: Spatial Aspects of Hormone Administration and Impact are Important 14. Effects of a Given Hormone Can be Widespread Across the Body; Central Effects Consonant with Peripheral Effects Form Coordinated, Unified Mechanisms 15. Hormones Can Act at All Levels of the Neuraxis to Exert Behavioral Effects; The Nature of the Behavioral Effect Depends on the Site of Action
Section V: Mechanisms: Molecular and Biophysical Mechanisms of Hormone Actions Give Clues to Future Therapeutic Strategies 16. In Responsive Neurons, Rapid hormone Effects Can Facilitate Later Genomic Actions 17. Gene Duplication and Splicing Products for Hormone Receptors in the CNS Often Have Different Behavioral Effects 18. Hormone Receptors and Other Nuclear Proteins Influence Hormone Responsiveness
Section VI: Environment: Environmental Variables Influence Hormone/Behavior Relations 19. Hormone Effects on Behavior Depend Upon Context 20. Behavioral/Environmental Context also Alters Hormone Release
Section VII: Evolution 21. Neuroendocrine Mechanisms Have Been Conserved to Provide Biologically Adaptive Body/Brain/Behavior Coordination
Donald W. Pfaff heads the Laboratory of Neurobiology and Behavior at The Rockefeller University. He received his scientific training at Harvard University and MIT and is a member of the National Academy of Science and a Fellow of the American Academy of Arts and Sciences. Pfaff's laboratory focuses on steroid hormones and brain function, interactions among transcription factors, luteinizing-hormone-releasing-hormone neurons, and genes influencing neuronal functions. He is the author or coauthor of over 10 books and more than 800 research publications.
Rubin, Robert T
VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Schneider, Jill E.
Professor Jill E. Schneider has been teaching undergraduate courses in Behavioral Endocrinology and other topics in neuroscience at Lehigh University for over 25 years. She received graduate and postdoctoral training in biology and neuroscience at Wesleyan University and the University of Massachusetts, respectively, and was awarded the Frank A. Beach Award from the Society for Behavioral Neuroendocrinology for outstanding research in behavioral neuroendocrinology in 1991. Professor Schneider's National Science Foundation-funded neuroendocrinology laboratory is focused on metabolic and hormonal mechanisms at the interface of reproductive and ingestive behavior.