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Monoamine Oxidase Inhibitors - Pipeline Insight, 2021

  • ID: 4382606
  • Clinical Trials
  • June 2021
  • Region: Global
  • DelveInsight

FEATURED COMPANIES

  • Avraham Pharmaceuticals
  • Ipsen
  • Newron Pharmaceuticals
  • Oryzon Genomics
  • PREXA SANTE
  • Provepharm
This “Monoamine Oxidase Inhibitors - Pipeline Insight, 2021” report provides comprehensive insights about 7+ companies and 7+ pipeline drugs in Monoamine Oxidase Inhibitors pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Geography Covered

  • Global coverage

Monoamine Oxidase Inhibitors Understanding


Monoamine Oxidase Inhibitors: Overview


Monoamine oxidase (MAO; EC 1.4.3.4.) is a widely distributed mitochondrial enzyme with high expression levels in gastro-intestinal and hepatic as well as neuronal tissues. There are two types of monoamine oxidase, A and B. The MOA A is mostly distributed in the placenta, gut, and liver, but MOA B is present in the brain, liver, and platelets.

Function - The enzyme catalyzes the oxidative deamination of a variety of monoamines, both endogenous and exogenous, and has major roles in metabolizing released neurotransmitters, and in detoxification of a large variety of endogenous and exogenous amines.

Monoamine Oxidase Inhibitors - Monoamine oxidase inhibitors are responsible for blocking the monoamine oxidase enzyme. The monoamine oxidase enzyme breaks down different types of neurotransmitters from the brain: norepinephrine, serotonin, dopamine, and tyramine. MAOIs inhibit the breakdown of these neurotransmitters thus, increasing their levels and allowing them to continue to influence the cells that have been affected by depression.

Monoamine Oxidase Inhibitors Emerging Drugs Chapters


This segment of the Monoamine Oxidase Inhibitors report encloses its detailed analysis of various drugs in different stages of clinical development, including phase III, II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.

Monoamine Oxidase Inhibitors Emerging Drugs


Ladostigil: Avraham Pharmaceuticals

Ladostigil (TV-3,326) is a novel neuroprotective agent being investigated for the treatment of neurodegenerative disorders likeAlzheimer's disease, Lewy body disease, and Parkinson's disease. It acts as a reversible acetylcholinesterase andbutyrylcholinesterase inhibitor, and an irreversible monoamine oxidase B inhibitor, and combines the mechanisms of action of older drugs like rivastigmine and rasagiline into a single molecule. In addition to its neuroprotective properties, ladostigil enhances the expression of neurotrophic factors like GDNF and BDNF, and may be capable of reversing some of the damage seen in neurodegenerative diseases via the induction of neurogenesis. Ladostigil also has antidepressant effects, and may be useful for treating comorbid depression and anxiety often seen in such diseases as well.

Safinamide: Newron Pharmaceuticals

A selective monoamine oxidase B (MAO-B) inhibitor, which reduces the degradation of secreted dopamine, helping to maintain the density of dopamine in the brain. The drug is in phase 2 stage of development for the treatment of Drug-induced dyskinesia.

Monoamine Oxidase Inhibitors: Therapeutic Assessment


This segment of the report provides insights about the different Monoamine Oxidase Inhibitors drugs segregated based on following parameters that define the scope of the report, such as:


Major Players working on Monoamine Oxidase Inhibitors


There are approx. 7+ key companies which are developing the Monoamine Oxidase Inhibitors. The companies which have their Monoamine Oxidase Inhibitors drug candidates in the most advanced stage, i.e. preregistration include, Amgen.

Phases


This report covers around 7+ products under different phases of clinical development like

  • Late-stage products (Phase III and
  • Mid-stage products (Phase II and
  • Early-stage products (Phase I/II and Phase I) along with the details of
  • Pre-clinical and Discovery stage candidates
  • Discontinued & Inactive candidates
  • Route of Administration

Monoamine Oxidase Inhibitors pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

  • Infusion
  • Intradermal
  • Intramuscular
  • Intranasal
  • Intravaginal
  • Oral
  • Parenteral
  • Subcutaneous
  • Topical
  • Molecule Type

Products have been categorized under various Molecule types such as

  • Vaccines
  • Monoclonal Antibody
  • Peptides
  • Polymer
  • Small molecule
  • Product Type
The drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

Monoamine Oxidase Inhibitors: Pipeline Development Activities


The report provides insights into different therapeutic candidates in phase II, I, preclinical and discovery stage. It also analyses Monoamine Oxidase Inhibitors therapeutic drugs key players involved in developing key drugs.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Monoamine Oxidase Inhibitors drugs.

Report Highlights


The companies and academics are working to assess challenges and seek opportunities that could influence Monoamine Oxidase Inhibitors R&D. The therapies under development are focused on novel approaches for Monoamine Oxidase Inhibitors.

Monoamine Oxidase Inhibitors Report Insights

  • Monoamine Oxidase Inhibitors Pipeline Analysis
  • Therapeutic Assessment
  • Unmet Needs
  • Impact of Drugs

Monoamine Oxidase Inhibitors Report Assessment

  • Pipeline Product Profiles
  • Therapeutic Assessment
  • Pipeline Assessment
  • Inactive drugs assessment
  • Unmet Needs

Key Questions Answered


Current Scenario and Emerging Therapies:

  • How many companies are developing Monoamine Oxidase Inhibitors drugs?
  • How many Monoamine Oxidase Inhibitors drugs are developed by each company?
  • How many emerging drugs are in mid-stage, and late-stage of development for Monoamine Oxidase Inhibitors?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Monoamine Oxidase Inhibitors therapeutics?
  • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Monoamine Oxidase Inhibitors and their status?
  • What are the key designations that have been granted to the emerging drugs?

Key Players

  • Avraham Pharmaceuticals
  • PREXA SANTE
  • Newron Pharmaceuticals
  • Oryzon Genomics
  • Ipsen
  • Provepharm
  • Roche
  • Changzhou Si Yao Pharmaceutical

Key Products

  • Ladostigil
  • Methylthioninium chloride
  • Safinamide
  • Vafidemstat
  • BN 82451
  • ProvayBlue
  • Sembragiline
  • Rasagiline

This report will be delivered within 2 business days.
Note: Product cover images may vary from those shown

FEATURED COMPANIES

  • Avraham Pharmaceuticals
  • Ipsen
  • Newron Pharmaceuticals
  • Oryzon Genomics
  • PREXA SANTE
  • Provepharm
Introduction

Executive Summary

Monoamine Oxidase Inhibitors: Overview
  • Structure
  • Mechanism of Action
Pipeline Therapeutics
  • Comparative Analysis
Therapeutic Assessment
  • Assessment by Product Type
  • Assessment by Stage and Product Type
  • Assessment by Route of Administration
  • Assessment by Stage and Route of Administration
  • Assessment by Molecule Type
  • Assessment by Stage and Molecule Type
Monoamine Oxidase Inhibitors - Analytical Perspective

In-depth Commercial Assessment
  • Monoamine Oxidase Inhibitors companies’ collaborations, Licensing, Acquisition -Deal Value Trends
Monoamine Oxidase Inhibitors Collaboration Deals
  • Company-Company Collaborations (Licensing / Partnering) Analysis
  • Company-University Collaborations (Licensing / Partnering) Analysis
Late Stage Products (Pre-registration)
  • Comparative Analysis
Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities
Mid Stage Products (Phase II)
  • Comparative Analysis
Safinamide: Newron Pharmaceuticals
  • Product Description
  • Research and Development
  • Product Development Activities
Early Stage Products (Phase I)
  • Comparative Analysis
Rasagiline: Changzhou Si Yao Pharmaceutical
  • Product Description
  • Research and Development
  • Product Development Activities
Pre-clinical and Discovery Stage Products
  • Comparative Analysis
Drug name: Company name
  • Product Description
  • Research and Development
  • Product Development Activities
Inactive Products
  • Comparative Analysis
Monoamine Oxidase Inhibitors Key Companies

Monoamine Oxidase Inhibitors Key Products

Monoamine Oxidase Inhibitors- Unmet Needs

Monoamine Oxidase Inhibitors- Market Drivers and Barriers

Monoamine Oxidase Inhibitors- Future Perspectives and Conclusion

Monoamine Oxidase Inhibitors Analyst Views

Monoamine Oxidase Inhibitors Key Companies

Appendix
Note: Product cover images may vary from those shown

A selection of companies mentioned in this report includes:

  • Avraham Pharmaceuticals
  • PREXA SANTE
  • Newron Pharmaceuticals
  • Oryzon Genomics
  • Ipsen
  • Provepharm
  • Roche
  • Changzhou Si Yao Pharmaceutical
Note: Product cover images may vary from those shown
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