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Hepatocyte Growth Factor - Pipeline Review, H2 2020

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    Drug Pipelines

  • 84 Pages
  • October 2020
  • Region: Global
  • Global Markets Direct
  • ID: 5189137
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Summary

According to the recently published report 'Hepatocyte Growth Factor - Pipeline Review, H2 2020'; Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) pipeline Target constitutes close to 15 molecules.

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Hepatocyte growth factor (HGF) is a paracrine cellular growth and morphogenic factor secreted by mesenchymal cells and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its receptor. It has a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration and in wound healing. In addition, HGF exerts protective effects on epithelial and non-epithelial organs (including the heart and brain) via anti-apoptotic and anti-inflammatory signals.

The report 'Hepatocyte Growth Factor - Pipeline Review, H2 2020' outlays comprehensive information on the Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies/Universities.

It also reviews key players involved in Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Preclinical and Discovery stages are 5, 3, 4 and 3 respectively. Report covers products from therapy areas Oncology, Cardiovascular, Central Nervous System, Dermatology, Genetic Disorders, Genito Urinary System And Sex Hormones, Hematological Disorders, Metabolic Disorders and Respiratory which include indications Amyotrophic Lateral Sclerosis, Colorectal Cancer, Critical Limb Ischemia, Gastric Cancer, Glioblastoma Multiforme (GBM), Lung Cancer, Melanoma, Ovarian Cancer, Pancreatic Cancer, Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD), Acute Renal Failure (ARF) (Acute Kidney Injury), Acute Spinal Cord Injury, Advanced Malignancy, Alzheimer's Disease, Arteriosclerosis, Breast Cancer, Cervical Cancer, Charcot-Marie-Tooth Disease Type I A, Colon Cancer, Coronary Artery Disease (CAD) (Ischemic Heart Disease), Dementia, Diabetic Ischemic Foot Ulcers, Diabetic Neuropathic Pain, Gallbladder Cancer, Head And Neck Cancer, Hepatocellular Carcinoma, Kidney Cancer (Renal Cell Cancer), Leiomyosarcoma, Liver Cancer, Lung Injury, Lymphedema, Lymphoma, Metastatic Cancer, Myocardial Infarction, Nasopharyngeal Cancer, Neuromuscular Disorders, Non-Small Cell Lung Cancer, Parkinson's Disease, Peripheral Artery Occlusive Disease (PAOD), Post-Operative Pain, Prostate Cancer, Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Scar, Solid Tumor and Thromboangiitis obliterans (Buerger disease).

Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope
  • The report provides a snapshot of the global therapeutic landscape for Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF)
  • The report reviews Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) targeted therapeutics

Reasons to Buy
  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF)Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

Introduction
  • Report Coverage

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Overview
Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Companies Involved in Therapeutics Development
  • AnGes Inc
  • Athira Pharma Inc
  • Beijing SH Bio-Tech Corp
  • Helixmith Co Ltd
  • i2 Pharmaceuticals Inc
  • Kringle Pharma Inc
  • Minerva Biotechnologies Corp
  • Molecular Partners AG
  • Yichang Humanwell Pharmaceutical Co Ltd
  • Yooyoung Pharm Co Ltd

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Drug Profiles
Ad-HGF - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

ATH-1017 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

beperminogene perplasmid - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

donaperminogene seltoplasmid - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Gene Therapy to Activate HGF for Critical Limb Ischemia and Chronic Post-Operative Pain - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Gene Therapy to activate HGF for Lung Injury - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Gene Therapy to Activate HGF for Neuro Muscular Disorders - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Gene Therapy to activate HGF for Peripheral Artery Occlusive Disease - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

KP-100IT - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Monoclonal Antibodies to Inhibit Hepatocyte Growth Factor for Metastatic Cancer - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

MP-0250 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

NK-4 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

SL-186 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

SL-188 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

YYB-101 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress

Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Dormant ProductsHepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Discontinued Products
Hepatocyte Growth Factor (Hepatopoietin A or Scatter Factor or HGF) - Product Development Milestones
  • Featured News & Press Releases
  • Oct 21, 2020: Athira Pharma to host educational webinar on the predictive nature of P300 to determine clinical benefit of Alzheimer’s Disease treatments
  • Oct 01, 2020: Athira Pharma announces initiation of patient dosing for the LIFT-AD study, a Phase 2/3 clinical trial to evaluate ATH-1017 for treatment of mild-to-moderate Alzheimer's Disease
  • Jul 27, 2020: Helixmith: VM202 CMT Phase I/IIA Trial Launched
  • Feb 18, 2020: Helixmith provides update of gene therapy Phase 3 Trial for Painful Diabetic Peripheral Neuropathy
  • Feb 04, 2020: AnGes, Inc. initiated Phase 2b study in the U.S. in patients with lower limb ischemic ulcers
  • Dec 27, 2019: Molecular Partners receives orphan drug designation for MP0250 for multiple myeloma
  • Dec 20, 2019: Genopis, plasmid DNA manufacturer in San Diego, to Launch GMP contract manufacturing business
  • Dec 12, 2019: Molecular Partners provides update on its Multiple Myeloma drug candidate MP-0250 at R&D Day
  • Dec 09, 2019: Athira Pharma presents positive data for NDX-1017 in Alzheimer's patients at 2019 clinical trials on Alzheimer's disease (CTAD) conference
  • Dec 07, 2019: Molecular Partners presents updated results of MP0250 in patients with Relapsed/Refractory Multiple Myeloma (MM) at American Society of Hematology Annual Meeting
  • Nov 20, 2019: Athira Pharma to present phase 1 data for NDX-1017 in oral presentation at 2019 clinical trials on Alzheimer's Disease (CTAD) Conference
  • Oct 07, 2019: Helixmith shows long-term safety and efficacy of VM202 for painful DPN patients in DPN phase 3-1b extension study
  • Oct 02, 2019: Athira Pharma Announces Completion of Phase 1b Clinical Trial of NDX-1017 in Alzheimers Patients
  • Sep 23, 2019: Helixmith: Topline results of DPN Phase III study
  • Sep 04, 2019: Notice regarding the launch of Collategene intramuscular injection 4 mg, an HGF gene therapy product

Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact
  • Disclaimer

List of Tables
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Indications, H2 2020
  • Number of Products under Development by Indications, H2 2020 (Contd..1), H2 2020
  • Number of Products under Development by Indications, H2 2020 (Contd..2), H2 2020
  • Number of Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020
  • Products under Development by Companies, H2 2020 (Contd..1), H2 2020
  • Products under Development by Companies, H2 2020 (Contd..2), H2 2020
  • Products under Development by Companies, H2 2020 (Contd..3), H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Stage and Route of Administration, H2 2020
  • Number of Products by Stage and Molecule Type, H2 2020
  • Pipeline by AnGes Inc, H2 2020
  • Pipeline by Athira Pharma Inc, H2 2020
  • Pipeline by Beijing SH Bio-Tech Corp, H2 2020
  • Pipeline by Helixmith Co Ltd, H2 2020
  • Pipeline by i2 Pharmaceuticals Inc, H2 2020
  • Pipeline by Kringle Pharma Inc, H2 2020
  • Pipeline by Minerva Biotechnologies Corp, H2 2020
  • Pipeline by Molecular Partners AG, H2 2020
  • Pipeline by Yichang Humanwell Pharmaceutical Co Ltd, H2 2020
  • Pipeline by Yooyoung Pharm Co Ltd, H2 2020
  • Dormant Products, H2 2020
  • Dormant Products, H2 2020 (Contd..1), H2 2020
  • Dormant Products, H2 2020 (Contd..2), H2 2020
  • Discontinued Products, H2 2020

List of Figures
  • Number of Products under Development by Stage of Development, H2 2020
  • Number of Products under Development by Therapy Areas, H2 2020
  • Number of Products under Development by Top 10 Indications, H2 2020
  • Number of Products by Mechanism of Actions, H2 2020
  • Number of Products by Stage and Mechanism of Actions, H2 2020
  • Number of Products by Routes of Administration, H2 2020
  • Number of Products by Stage and Routes of Administration, H2 2020
  • Number of Products by Molecule Types, H2 2020
  • Number of Products by Stage and Molecule Types, H2 2020

Companies Mentioned (Partial List)

A selection of companies mentioned in this report includes, but is not limited to:

  • AnGes Inc
  • Athira Pharma Inc
  • Beijing SH Bio-Tech Corp
  • Helixmith Co Ltd
  • i2 Pharmaceuticals Inc
  • Kringle Pharma Inc
  • Minerva Biotechnologies Corp
  • Molecular Partners AG
  • Yichang Humanwell Pharmaceutical Co Ltd
  • Yooyoung Pharm Co Ltd