Engineering of Biomaterials for Drug Delivery Systems: Beyond Polyethylene Glycol examines the combined issues of PEGylation and viable biomaterials as alternatives. With a strong focus on polymeric biomaterials, the book first reviews the major issues associated with PEGylation and its use in vivo. Chapters then focus on alternative polymer systems for drug delivery systems. Finally, nanoparticles and future perspectives are examined. This book is a valuable resource for scientists and researchers in biomaterials, pharmaceuticals and nanotechnology, and all those who wish to broaden their knowledge in this field.
- Provides a self-contained work for the field of biomaterials for drug delivery
- Summarizes the current knowledge on PEGylation and strategies for bypassing it
- Presents research on an important, though under-represented issue in biomaterials
- Written by a world-class team of research scientists, engineers and clinicians
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2. PEGylated proteins
3. PEGylation and anti-PEG antibodies
4. Poly (zwitterions)
5. Poly (glycerols)
6. Poly (oxazolines)
7. Poly (aminoacids)
8. Poly (acylamides) and related systems
9. Poly (vinylpyrrolidones)
10. Sugar based systems (trehalose)
11. Polypeptide alternatives (PASylation and XTen) to PEG
12. DDS based on non-immunogenic biopolymers
13. Non-PEGylated nanoparticles
14. Summary and future perspectives
Anilkumar PArambath is a skilled materials/polymer chemist with 11 years of synthesis and characterization of polymers, soft materials, nanomaterials and biomaterials. His particular research interests include Drug Delivery, Bio-conjugation, Bio-imaging Agents, Bio- compatible Polymers, Protein Resistant Polymers, Hyperbrached Polymers, Polymer Brushes, Self-assembly, Amphiphiles, Micelles, Carbon Nanostructures, Luminescent Materials, Conducting Polymers, and Thermoplastics.