Precision Medicine. Tools and Quantitative Approaches

Table of Contents

1. Ethical Aspects of Precision Medicine: An Introduction to the Ethics and Concept of Clinical Innovation
2. Issues and Challenges in the Systematic Evaluation of Biomarker Tests
3. Statistical Learning in Precision Medicine
4. Biobanks as Basis of Individualized Medicine: Challenges Toward Harmonization
5. Sequencing in Precision Medicine
6. Workflow for Circulating miRNA Identification and Development in Cancer Research: Methodological Considerations
7. Analyzing the Effects of Genetic Variation in Noncoding Genomic Regions
8. Synthesis of Magnetic Iron Oxide Nanoparticles
9. Magnetic Particle Imaging
10. Nanoparticles and Nanosized Structures in Diagnostics and Therapy
11. Interaction of Nanoparticles With Biomolecules, Protein, Enzymes, and Its Applications
12. Modeling and Simulating Carcinogenesis
13. Sepsis: A Challenging Disease With New Promises for Personalized Medicine and Biomarker Discovery
14. Asphyxia Diagnosis: An Example of Translational Precision Medicine
15. Biomarker for Alzheimer's Disease

Authors

Hans-Peter Deigner Professor of Pharmacology, Dean Faculty of Medical and Life Sciences (MLS) (HPD), Hochschule Furtwangen University, Germany. Hans-Peter has extensive experience in omics and biomarker research including several senior management positions in Biotech companies. He authors about 75 peer reviewed articles and 40 patents / patent applications and is a regular reviewer for numerous scientific journals and funding agencies. While holding senior management positions in biotech industry he has developed novel molecular diagnostics from the idea via the prototype to the final commercial product. From 2004-2006 he took up a chair in Biomedicinal Chemistry, University of East Anglia, Norwich, UK. Hans-Peter Deigner graduated in pharmaceutical chemistry, Heidelberg University, Germany and after a position as research associate at Harvard Medical School returned to Heidelberg to finish his habilitation and to work as group leader and senior lecturer/associate professor. Matthias Kohl Professor of Mathematics in Biology and Medicine, Furtwangen University, Germany. He is the Head Institute of Precision Medicine, Furtwangen University, Head Steinbeis Transfer Center Personalized Medicine, Steinbeis GmbH & Co KG, Stuttgart, Member Baden-Württemberg Center of Applied Research (BW-CAR), Member Institute of Applied Research, IAF, Furtwangen University, Guest researcher and lecturer at IMBS Master, Freiburg University and Dean of Studies "Medical Diagnostic Technologies (M.Sc.)”, Furtwangen University.