Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience.
- Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition
- Contains new chapters that focus on subjects recent to the field
- Includes well-illustrated material, with diagrams, charts, and tables
- Contains compelling case studies and chapters written by world experts
PART I. CELLULAR AND MOLECULAR MORPHOGENESIS OF THE NERVOUS SYSTEM PART II. DEVELOPMENTAL NEUROBIOLOGY/TOXICOLOGY PART III. SYNAPTOGENESIS AND NEUROTRANSMISSION PART IV. NUTRIENT AND CHEMICAL DISPOSITION PART V. BEHAVIORAL ASSESSMENT PART VI. CLINICAL ASSESSMENT AND EPIDEMIOLOGY PART VII. SPECIFIC NEUROTOXIC SYNDROMES PART VIII. RISK ASSESSMENT
Dr. Slikker is the Director of FDA's National Center for Toxicological Research (NCTR). He received his Ph.D. in Pharmacology and Toxicology from the University of California at Davis. Dr. Slikker holds Adjunct Professorships in the Departments of Pediatrics, and Pharmacology and Toxicology at the University of Arkansas for Medical Sciences. He has held committee chairmanships or elected offices in several scientific societies, including the Teratology Society (serving as President) and the American Society for Pharmacology and Experimental Therapeutics (Chair, Developmental Pharmacology Section and member of the Program Committee) and co-founder and past President of the MidSouth Computational Biology and Bioinformatics Society. He is currently Associate Editor for NeuroToxicology and Toxicological Sciences and is the past President of The Academy of Toxicological Sciences, the Society of Toxicology (Presidential term ended 2013), recipient of the 2014 George H. Scott Memorial Award from The Toxicology Forum and invited to present the Warkany Lecture at the 2015 annual meeting of the Teratology Society. Dr. Slikker has authored or co-authored over 300 publications in the areas of transplancental pharmacokinetics, developmental neurotoxicology, neuroprotection, systems biology, and risk assessment. He has also served on several national/international advisory panels for the International Life Sciences Institute (ILSI)/Health and Environmental Sciences Institute (HESI), Chemical Industry Institute of Toxicology (CIIT) Centers for Health Research, Environmental Protection Agency (EPA), National Institute of Environmental Health Sciences (NIEHS), National Academy of Sciences (NAS), National Institutes of Health (NIH) and World Health Organization (WHO).
Paule, Merle G.
Dr. Paule received his B.S. in Biochemistry and his Ph.D. in Pharmacology and Toxicology at the University of California at Davis. In 1983 he began work at the FDA's National Center for Toxicological Research in Jefferson, Arkansas, where he remains today. He attained certification as one of FDA's Senior Biomedical Research Scientists in 2000 and in 2005 became the Director of the Division of Neurotoxicology at NCTR. Dr. Paule has played a major role in developing an automated system for monitoring multiple complex brain functions in nonhuman primates, children, and rodents. Utilization of similar or identical behavioral tasks across species serves to facilitate the interspecies extrapolation of exposure data and, thus, the risk assessment process. He is past President of the Behavioral Toxicology Society, the Neurobehavioral Teratology Society and the Neurotoxicology Specialty Section of the Society of Toxicology and Associate Editor for the journals NeuroToxicology and Neurotoxicology and Teratology. Dr. Paule has published over 225 research articles and 30 book chapters and holds Adjunct Professorships at the University of Arkansas for Medical Sciences in the Departments of Pharmacology and Toxicology and in Pediatrics. He is an elected Fellow in the Academy of Toxicological Sciences and in the International Behavioral Neuroscience Society.
Cheng Wang, M.D., Ph.D. is a Senior Scientist at the National Center for Toxicological Research (NCTR)/US Food and Drug Administration (FDA). He is also an Adjunct Faculty member in the Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences (UAMS).
Dr. Wang is the P.I. of protocols (grants) supported by the NCTR/FDA, National Toxicology Program and NICHD. He is currently responsible for leading a research team that provides unique and highly specialized skills in neural toxicology, pharmacology, systems biology and stem cell biology research. Dr. Wang has published more than 80 peer-reviewed research articles in prestigious journals and 20 book chapters. Dr. Wang is a Co-Editor-in-Chief of the book entitled "Developmental Neurotoxicology Research: Principles, Models, Techniques, Strategies, and Mechanisms and "Neural Cell Biology. He also serves as Editor-in-Chief for Journal of Evolving Stem Cell Research (JESR) and Global Journal of Anesthesiology.
Dr. Wang was awarded the Outstanding Performance Award at the Society of Toxicology 44th Annual Meeting and the 2007 FDA Scientific Achievement Award for Excellence in Laboratory Science. He also was awarded a 2008 FDA Group Recognition Award for his participation in the Pediatric Anesthesia Research Group.
Neural Stem Cell Biology
Application of Systems Biology in Neurotoxicological Studies during Development
Activity-induced Synaptic Plasticity and Neural Cell Adhesion Molecule
Potential Pediatric Anesthetic-induced Neural Cell Death and the Potential Role of Neurotransmission (Mechanistic Studies)
Mitochondrial DNA Damage and Expression Levels of DNA Repair Enzymes