Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The -Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance.
With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.
- Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine
- Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data
- Features chapter contributions by leading international experts
INTRODUCTION 1. Human Genome Projects: the starting point 2. Is the classic spermiogram still informative? How did it develop and where is it going? GENOMICS 3. Genetics variations and male infertility 4. Preconceptional analysis of monogenic diseases 5. Genetic selection of the human embryos: from FISH to NGS, past and future 6. Non invasive prenatal diagnosis 7. New genetic point mutations in male infertility 8. Telomeres in Germline and Early Embryo
An Overview 9. Human Protamine Genes Polymorphisms As A Possible Cause Underlying Male Infertility FUNCTIONAL GENOMICS OR TRANSCRIPTOMICS 10. The molecular signature of the endometrial receptivity: research and clinical application 11. Gene expression of cumulus cells: an indirect diagnosis of oocyte qualit 12. Variations in the gene expression of the sperm: clinical use 13. Altered Transcriptomic Profiles Associated with Male Infertility 14. Small RNAs in human sperm PROTEOMICS AND METABOLOMICS 15. Non invasive methods of embryo selection 16. Proteomics and metabolomics studies and clinical outcomes EPIGENOMICS 17. Epigenetics, spermatogenesis and male infertility 18. Changes in DNA methylation related with male infertility 19. Stem Cell Derived Spermatozoa 20. Unraveling the causes of failed fertilization after ICSI due to oocyte activation deficiency COMPUTATIONAL BIOLOGY 21. Computational approaches in Reproductomics CONCLUSION 22. Year 2050: The "-Omics technologies and the personalized Assisted Reproduction
Jose Horcajadas, PhD, is Associate Professor at the University Pablo de Olavide, Sevilla, Spain. Dr. Horcajadas is an expert in translational research with emphasis on human implantation. He has more than 50 publications in high-impact peer reviewed journals including The Journal of Endocrinology and Metabolism. For the past 3 years Dr. Horcajadas has been an active collaborator in the development of a three-dimensional endometrial culture system at The Jones Institute, which has resulted in several significant publications and presentations. Dr. Horcajadas has also presented at various national and international meetings.
Professor Jaime Gosalvez is a permanent member of the Department of Genetics at the Universidad Autonoma of Madrid in Spain. He received his Ph.D. in Biology with specialization in Genetics in 1979. He teaches courses on Molecular Cytogenetics, Models and Evolutive Processes and Advanced Technologies for Biology. His research interests are in the areas of molecular cytogenetics with special emphasis on DNA structure and function. He is deeply involved in the analysis of different aspects of the DNA molecule in the sperm and their possible implications in male infertility, with special emphasis in human, other mammalian species and fish, as well as those clinical aspects of the male factor to achieve pregnancy. Dr. Gosálvez has published more than 250 original articles and 190 abstracts have been presented in different national and international meetings. He has published 15 book chapters in the area of cytogenetics and sperm quality assessment and has edited two books. He has been the Principal Investigator of more than 30 national and international competitive research applications, and he is co-author of two patents with world-wide protection.