Biomedical Applications of Functionalized Nanomaterials. Concepts, Development and Clinical Translation. Micro and Nano Technologies

Table of Contents

Introduction: From the "magic bullet" to advanced nanomaterials: An historical perspective

Part I. Ligand selection and functionalization of nanomaterials 1. Phage display technology for screening antibody fragments 2. Bioengineered approaches for site-orientation of peptide-based ligands of nanomaterials 3. Engineered protein variants for bioconjugation 4. Engineering of nanozymes for biomedical applications 5. Strategies for the functionalization of mesoporous nanomaterials for biomedical use 6. Systematic evolution of ligands by exponential enrichment (SELEX) for aptamer selection 7. Biological methodologies for assessment of functionality of nanomaterials

Part II. Specific applications of functionalized nanomaterials in therapy and diagnostics 8. Functionalized graphene-based materials for bioimaging applications 9. Multifunctional magnetic nanoparticles for theranostic applications 10. Stimuli-sensitive grafting polymers for targeted anticancer drug delivery 11. Functional moieties for intracellular traffic of nanomaterials 12. Biofunctionalized mesoporous silica nanomaterials for nuclei targeting 13. Lipid-derived nanoparticles for targeted delivery of siRNA 14. Aptamer-siRNA nanoparticles for targeted anti-HIV therapeutics 15. Peptide and protein self-assembled nanofibers for vaccine development and immunotherapy 16. Functional biomaterials for vascular tissue engineering 17. Functionalized hydrogels for culture and delivery of cells

Part III. Manufacturing, regulatory challenges and clinical testing of functionalized nanomaterial-based products 18. Manufacturing and safety guidelines for the manufactured functional nanomaterials 19. Challenges for planning clinical trials of functionalized nanomaterials 20. Clinical testing of ACCURINS® therapeutics: challenges and lessons learned

Authors

Bruno Sarmento Affiliated Investigator, INEB-Instituto de Engenharia Biomédica, University of Porto, Portugal and Assistant Professor, Pharmaceutical Technology, Department of Pharmaceutical Sciences, ISCS-N, Gandra, Portugal. Bruno Sarmento is an Affiliated Investigator at the INEB-Instituto de Engenharia Biomédica, based at the University of Porto, Portugal and is Assistant Professor of Pharmaceutical Technology in the Department of Pharmaceutical Sciences, at ISCS-N, Gandra, Portugal. His current research is focused on the study of nanomedicines and their application in the pharmaceutical and biomedical fields, as well as the use of in vitro cell models as a tool to correlate the transport of biopharmaceuticals and nanoparticles across human mucosa. Bruno has been involved with more than two hundred publications, including three edited books in the field of Pharmaceutical Technology and Nanomedicine, more than one hundred papers in international peer-review journals and several conference proceedings. He also serves as an editorial board member for several international journals and an evaluator of research projects form international agencies. He is an active member of several international associations (AAPS, CRS, EUFEPS, EFSD, FIP) and works on biotechnology and health post-graduate programs at national and international level. Jose Das Neves Post-Doctoral Researcher at INEB, the Instituto de Engenharia Biomédica, Porto, Portugal. José das Neves is a Post-Doctoral Researcher at INEB, the Instituto de Engenharia Biomédica, Porto, Portugal. His research interests focuses on vaginal drug delivery, nanotechnology-based drug carriers and biomaterials. He has previously written 7 book chapters and is the co-editor of three books.